Multimethod assessing the prognosis affecting factors of hospitalized children with burns in Zunyi, southwest China

Li, Xiahong; Wang, Xue; Wang, Tao; Yu, Huiting; Zhou, Yanna; Wang, Haiyan; Shi, Xiuquan

doi:10.1007/s00508-020-01676-z

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…Previous studies have shown that most pediatric burn patients were < 2 years old, and boys occupied the majority ( Li et al, 2021 ; Ruan et al, 2021 ; Sarginson et al, 2021 ). So did those pediatric burn patients with wound infections in this study.…”

Section: Discussionmentioning

confidence: 99%

The clinical characteristics and microbiological investigation of pediatric burn patients with wound infections in a tertiary hospital in Ningbo, China: A ten-year retrospective study

Ke¹,

Ye²,

Zhu³

et al. 2023

Front. Microbiol.

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Burn is one of the leading causes of death and disability in children worldwide, and wound infection is an excellent challenge in burn treatment. We performed a retrospective review of pediatric burn patients with wound infections to reveal their clinical data and investigate pathogens’ distribution and drug resistance patterns to provide references for treatment. As a result, 330 pediatric burn patients with wound infections were identified; 65.8% (217/330) were < 2 years old. Most of the injuries were scalded and involved <10% total body surface area in size (TBSA), mainly causing II-degree burn and II + III-degree burn. Three hundred and fifty nine strains of pathogens were isolated, the primary pathogens were Staphylococcus aureus (45.4%) and Pseudomonas aeruginosa (18.7%). Both S. aureus and P. aeruginosa isolated from 2012 to 2016 were more likely to be multi-resistant than those isolated from 2017 to 2021, as they were significantly associated with resistance to ≥4 Clinical and Laboratory Standard Institute (CLSI) classes (p = 0.040 and 0.006, respectively). In conclusion, children aged <2 years old were the main pediatric burn patients with wound infections. The primary bacteria isolated from the wound were S. aureus and P. aeruginosa, with a decreasing tendency of multi-resistance.

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Section: Discussionmentioning

confidence: 99%

The clinical characteristics and microbiological investigation of pediatric burn patients with wound infections in a tertiary hospital in Ningbo, China: A ten-year retrospective study

Ke¹,

Ye²,

Zhu³

et al. 2023

Front. Microbiol.

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“…In the Pacific region, we found 4 epidemiological studies, including: 2 in China [27,28], one in Korea [29], and one in Australia [30].…”

Section: Western Pacific Countriesmentioning

confidence: 99%

“…[30]. The age of children and youths in one of the studies performed in China was limited to the age period from 1.25 years to 3.75 years, although the sample size (n=11) and duration of the study (1 year) were sufficient [28]. Such differences in the sample sizes of epidemiological studies in our analysis were due to the fact that the chosen period of data analysis was very variable: from one year [28] to ten years [30].…”

Section: Western Pacific Countriesmentioning

confidence: 99%

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Epidemiology Of Thermal Hand Injury In Children And Youths In Russia And Abroad

et al. 2022

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Thermal hand injury (THI) is a severe open damage of superficial and deep hand tissues caused by exposure to high temperatures. THI is characterized by damage of different severity grades to the tissues and hand structures, vascular changes, occurrence of local and multipart inflammatory responses, formation of secondary cicatricial skin changes, as well as of inner tissues, and/or secondary deformation and dysfunction of the hand. Objective -Systematization and update of knowledge about THI occurrence frequency among children and youths. Material and Methods -We analyzed full-text publications originated in Russia and abroad, including: original articles, thematic and systematic reviews, along with Cochrane Reviews. Our search covered the articles published in 2011-2021. We analyzed 368 publications and included 29 studies in our analysis. Results -Mean frequency of THI occurrence among children and youths was as follows: 10.0% in countries of South-East Asia, 12.3% in Mediterranean countries, 23.9% in European countries, 28.4% in Western Pacific countries, 33.0% in African countries, and 36% in countries of the Americas. Mean frequency of THI occurrence among children and adolescents worldwide was 31.3%, and 29.5% in Russia. Conclusion -Mean frequency of THI occurrence, compared with other thermal injuries in children and adolescents, is quite high and makes up for about one-third of all cases (31.3%). Hence, an importance of this interdisciplinary problem in combustiology, as well as in traumatology and plastic surgery, since the long-term consequences of THI in people who experienced it in their childhood or adolescence largely depend on close interaction of physicians representing various specialties.

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“…2 Early measures to control the disease and promote wound healing are particularly important. [3][4][5] For burns and scalds, Silver Sulfadiazine (SSD) is one of the commonly used clinical drugs, which have anti-inflammatory, anti-bacterial and analgesic effects. 6 However, in recent years, with the emergence of problems such as the abuse of antibiotics and the increased antibacterial drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Luteolin is an Effective Component of Platycodon grandiflorus in Promoting Wound Healing in Rats with Cutaneous Scald Injury

Wang¹,

Hu²,

Zhi-lian³

et al. 2022

CCID

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Background Platycodon grandiflorus could significantly improve the pathological results of cutaneous scald injury, reduce the release of inflammatory factors and promote angiogenesis. This study investigated the wound healing effect of luteolin, an active component of P. grandiflorus , on induced cutaneous scald injury in Sprague-Dawley (SD) rats. Methods The protein expression levels of TNF-α and IL-6 were detected by ELISA. QRT-PCR was adopted to detect the expression of TGF-β1 and VEGF. Histopathological changes of scald wounds were analyzed by hematoxylin-eosin staining. Cell viability and migration ability were detected by CCK-8 assay and scratch assay. Results Both in vivo and in vitro experiments showed that luteolin promoted wound healing of cutaneous scald injury. Gene Oncology (GO) functional analysis and rescue experiments showed that endothelial nitric oxide synthase 3 (NOS3) was the critical target of luteolin in treating cutaneous scald. Conclusion This study demonstrated that luteolin is an effective component of P. grandiflorus and is effective in the treatment of cutaneous scald injury.

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Multimethod assessing the prognosis affecting factors of hospitalized children with burns in Zunyi, southwest China

Cited by 6 publications

References 31 publications

The clinical characteristics and microbiological investigation of pediatric burn patients with wound infections in a tertiary hospital in Ningbo, China: A ten-year retrospective study

The clinical characteristics and microbiological investigation of pediatric burn patients with wound infections in a tertiary hospital in Ningbo, China: A ten-year retrospective study

Epidemiology Of Thermal Hand Injury In Children And Youths In Russia And Abroad

Luteolin is an Effective Component of Platycodon grandiflorus in Promoting Wound Healing in Rats with Cutaneous Scald Injury

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