Multimodal image-guided prostate fusion biopsy based on automatic deformable registration

Zettinig, Oliver; Shah, Amit; Hennersperger, Christoph; Eiber, Matthias; Kroll, Christine; Kübler, Hubert; Maurer, Tobias; Milletarì, Fausto; Rackerseder, Julia; Berge, Christian Schulte zu; Storz, Enno; Frisch, B.; Navab, Nassir

doi:10.1007/s11548-015-1233-y

Cited by 66 publications

(44 citation statements)

References 30 publications

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“…Before the advent of PSMA PET, 18 F-choline was the primary PET/CT tracer for detection of prostate cancer. In a prospective study on 18 F-choline PET in conjunction with MRI, Hartenbach et al (5) found discrimination between lesions with a GS of more than 6 versus 6 or less based on mean lesional tracer uptake. In our analysis, 68 Ga-PSMA PET similarly showed a significant difference in tracer uptake for segments with a GS of more than 6 versus 6 or less, although our cohort included relatively few samples that were a GS of 6 or less.…”

Section: Discussionmentioning

confidence: 99%

“…The 18 F-choline PET analysis of lesions larger than 5 mm in diameter demonstrated 68% accuracy, as compared with 72% accuracy for 68 Ga-PSMA PET in our study. The slightly higher accuracy of 68 Ga-PSMA PET might, notwithstanding group differences in patient cohort and sample analysis, be due to inherently superior tumor-to-background uptake for 68 Ga-PSMA as compared with 18 F-choline (6). Indeed, tumor-to-background uptake is critical for the diagnostic accuracy of radiolabeled PSMA ligands.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, tumor-to-background uptake is critical for the diagnostic accuracy of radiolabeled PSMA ligands. Rowe et al, in their prospective analyses of the performance of PET/CT in conjunction with MRI using the 18 F-labeled PSMA ligand 18 …”

Section: Discussionmentioning

confidence: 99%

“…STB PET3 (SUV $ 3.6) was 55% in LM segment (histopathology, 100%) and is delineated by red line. (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…PET/CT with radiolabeled choline analogs is widely used in clinical practice for prostate cancer staging. In a prospective study, 18 F-fluoroethylcholine PET demonstrated higher accuracy than MRI for the detection of primary prostate cancer; however, specificity was limited by choline uptake in benign lesions (5). PET with ligands for the prostate-specific membrane antigen (PSMA) might overcome this limitation.…”

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confidence: 99%

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⁶⁸Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

et al. 2016

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We evaluated the accuracy of PET/CT with 68 Ga-PSMA-HBED-CC-a 68 Ga-conjugated ligand of human prostate-specific membrane antigen (PSMA)-to localize cancer in the prostate and surrounding tissue at initial diagnosis. Methods: Twenty-one patients with biopsy-proven prostate cancer underwent 68 Ga-PSMA-HBED-CC ( 68 Ga-PSMA) PET/CT at a median of 4 d (range, 0-47 d) before radical prostatectomy. Based on a 6-segment model, the Gleason score and proportion of tumor tissue within each segment (segmental tumor burden, or STB) as determined by histopathology (STB HP ) were correlated with SUV max and STB as determined by different SUV cutoffs for 68 Ga-PSMA PET (STB ). Furthermore, the involvement of seminal vesicles and other extracapsular extension were assessed by histopathology and PET/CT. Results: Histopathology-positive segments (n 5 100 of 126; 79%) demonstrated a significantly higher mean ± SD SUV max (11.8 ± 7.6) than histopathology-negative segments (4.9 ± 2.9; P , 0.001). Receiver-operating-characteristic analysis revealed an optimal SUV max cutoff of 6.5 for discrimination of histopathology-positive segments from histopathology-negative segments (area under the curve, 0.84; P , 0.001), which gave 67% sensitivity, 92% specificity, a 97% positive predictive value, a 42% negative predictive value, and 72% accuracy. STB PET3 as determined by (2 · blood SUV) 1 (2 · SD) correlated best with STB HP (Pearson ρ 5 0.68; P , 0.001; mean difference ± SD, 19% ± 15%). PET/CT correctly detected invasion of seminal vesicles (n 5 11 of 21 patients; 52%) with 86% accuracy and tumor spread through the capsule (n 5 12; 57%) with 71% accuracy. Conclusion: 68 Ga-PSMA PET/CT accurately detected the location and extent of primary prostate cancer. Our preliminary findings warrant further investigation of 68 Ga-PSMA PET/CT in conjunction with needle biopsy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…STB PET3 (SUV $ 3.6) was 55% in LM segment (histopathology, 100%) and is delineated by red line. (17,18).…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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⁶⁸Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

et al. 2016

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Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Dubinsky

Khokhlova

et al. 2019

J of Ultrasound Medicine

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This article reviews the most current methods and technological aspects of highintensity focused ultrasound (HIFU), which is termed histotripsy. The rationale for focal therapy for prostate carcinoma rather than prostatectomy, which is being used extensively throughout Europe and Asia, is presented, and an argument for why HIFU is the modality of choice for primary therapy and recurrent disease is offered. The article presents a review of the technical advances including higher ultrasound beam energy than current thermal HIFU which allows for more accurate tissue targeting, less collateral tissue damage, and faster treatment times. Finally, the article presents a discussion about the advantage of ultrasound guidance for histotripsy in preference to magnetic resonance imaging guidance primarily based on cost, ease of application, and portability.

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Pharmacological upregulation of prostate‐specific membrane antigen (PSMA) expression in prostate cancer cells

et al. 2018

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Multimodal image-guided prostate fusion biopsy based on automatic deformable registration

Abstract: The system is able to successfully map suspicious regions from PET/MRI to the interventional TRUS image.

Cited by 66 publications

References 30 publications

⁶⁸Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

⁶⁸Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Pharmacological upregulation of prostate‐specific membrane antigen (PSMA) expression in prostate cancer cells

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Multimodal image-guided prostate fusion biopsy based on automatic deformable registration

Abstract: The system is able to successfully map suspicious regions from PET/MRI to the interventional TRUS image.

Cited by 66 publications

References 30 publications

68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Pharmacological upregulation of prostate‐specific membrane antigen (PSMA) expression in prostate cancer cells

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⁶⁸Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer

⁶⁸Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer