Multimodal imaging for improved diagnosis and treatment of cancers

Tempany, Clare M.; Jayender, Jagadeesan; Kapur, Tina; Bueno, Raphael; Golby, Alexandra J.; Agar, Nathalie Y.R.; Jólesz, Ferenc A.

doi:10.1002/cncr.29012

Cited by 103 publications

(59 citation statements)

References 52 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MR imager can traverse on rails to a fully draped patient on the operating table. The operating room is equipped with MR imaging conditional anesthesia delivery, monitoring systems, and instruments required to perform BCS (19). All images and information relevant to the procedure are accessible in the operating suite, with selected imaging series displayed on large liquid crystal display monitors within the room that enable surgeons to continuously view relevant imaging data.…”

Section: Methodsmentioning

confidence: 99%

Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results

Gombos¹,

Jayender²,

Richman³

et al. 2016

Radiology

Self Cite

View full text Add to dashboard Cite

Purpose To use intraoperative supine magnetic resonance (MR) imaging to quantify breast tumor deformation and displacement secondary to the change in patient positioning from imaging (prone) to surgery (supine) and to evaluate residual tumor immediately after breast-conserving surgery (BCS). Materials and Methods Fifteen women gave informed written consent to participate in this prospective HIPAA-compliant, institutional review board–approved study between April 2012 and November 2014. Twelve patients underwent lumpectomy and postsurgical intraoperative supine MR imaging. Six of 12 patients underwent both pre- and postsurgical supine MR imaging. Geometric, structural, and heterogeneity metrics of the cancer and distances of the tumor from the nipple, chest wall, and skin were computed. Mean and standard deviations of the changes in volume, surface area, compactness, spherical disproportion, sphericity, and distances from key landmarks were computed from tumor models. Imaging duration was recorded. Results The mean differences in tumor deformation metrics between prone and supine imaging were as follows: volume, 23.8% (range, −30% to 103.95%); surface area, 6.5% (range, −13.24% to 63%); compactness, 16.2% (range, −23% to 47.3%); sphericity, 6.8% (range, −9.10% to 20.78%); and decrease in spherical disproportion, −11.3% (range, −60.81% to 76.95%). All tumors were closer to the chest wall on supine images than on prone images. No evidence of residual tumor was seen on MR images obtained after the procedures. Mean duration of pre- and postoperative supine MR imaging was 25 minutes (range, 18.4–31.6 minutes) and 19 minutes (range, 15.1–22.9 minutes), respectively. Conclusion Intraoperative supine breast MR imaging, when performed in conjunction with standard prone breast MR imaging, enables quantification of breast tumor deformation and displacement secondary to changes in patient positioning from standard imaging (prone) to surgery (supine) and may help clinicians evaluate for residual tumor immediately after BCS.

show abstract

Section: Methodsmentioning

confidence: 99%

Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results

Gombos¹,

Jayender²,

Richman³

et al. 2016

Radiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Subjects had at least one focal lesion suspicious for prostate cancer on pre-procedural 3T mpMRI (T 2 W TSE, apparent diffusion coefficient (ADC), and dynamic contrast enhanced (DCE) imaging [1, 2]), and either had a previous trans-rectal ultrasound-guided (TRUS) biopsy which did not yield a diagnosis, or could not undergo TRUS biopsy, e.g., due to prior rectal surgery, inflammation of the rectum. Patients were either under intravenous conscious sedation or general anesthesia for the biopsy.…”

Section: Methodsmentioning

confidence: 99%

Characterization of gradient echo signal decays in healthy and cancerous prostate at 3T improves with a Gaussian augmentation of the mono-exponential (GAME) model

et al. 2016

View full text Add to dashboard Cite

A biomarker of cancer aggressiveness, such as hypoxia, could substantially impact treatment decisions in the prostate, especially radiation therapy, by balancing treatment morbidity (urinary incontinence, erectile dysfunction, etc.) against mortality. R2* mapping with Mono-Exponential (ME) decay modeling has shown potential for identifying areas of prostate cancer hypoxia at 1.5T. However, Gaussian deviations from ME decay have been observed in other tissues at 3T. The purpose of this study is to assess whether gradient-echo signal decays are better characterized by a standard ME decay model, or a Gaussian Augmentation of the Mono-Exponential (GAME) decay model, in the prostate at 3T. Multi-gradient-echo signals were acquired on 20 consecutive patients with a clinical suspicion of prostate cancer undergoing MR-guided prostate biopsies. Data were fitted with both ME and GAME models. The information content of these models were compared using Akaike’s Information Criterion (second-order, AICC), in skeletal muscle, the prostate central gland (CG), and peripheral zone (PZ) regions-of-interest (ROIs). The GAME model had higher information content in 30% of the prostate on average (across all patients and ROIs), covering up to 67% of cancerous PZ ROIs, and up to 100% of cancerous CG ROIs (in individual patients). The higher information content of GAME became more prominent in regions that would be assumed hypoxic using ME alone, reaching 50% of the PZ and 70% of the CG as ME R2* approached 40 s−1. R2* mapping may have important applications in MRI; however, information lost due to modeling could mask differences in parameters due to underlying tissue anatomy or physiology. The GAME model improves characterization of signal behavior in the prostate at 3T, and may increase the potential for determining correlates of fit parameters with biomarkers, such as of oxygenation status.

show abstract

“…Sixth, evidence is emerging that advanced MRI and directed biopsy techniques could allow for improved disease characterization and staging. 29 How best to incorporate the GPC value obtained from TRUS-guided biopsy when such information is available for clinical decision-making requires additional study. Finally, variation exists in the measurement of tumor foci lengths, which can result in discrepant GPC values.…”

Section: Discussionmentioning

confidence: 99%

Greatest Percentage Involved Core Length and Risk of Clinically Significant Prostate-Specific Antigen Failure After Radical Prostatectomy

Cheney

Zhang

Chen

et al. 2015

Clinical Genitourinary Cancer

View full text Add to dashboard Cite

Multimodal imaging for improved diagnosis and treatment of cancers

Cited by 103 publications

References 52 publications

Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results

Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results

Characterization of gradient echo signal decays in healthy and cancerous prostate at 3T improves with a Gaussian augmentation of the mono-exponential (GAME) model

Greatest Percentage Involved Core Length and Risk of Clinically Significant Prostate-Specific Antigen Failure After Radical Prostatectomy

Contact Info

Product

Resources

About