Multimodal Imaging in Ocular Toxoplasmosis

Brandão-de-Resende, Camilo; Balasundaram, Manohar Babu; Mahendradas, Padmamalini; Vasconcelos-Santos, Daniel Vítor

doi:10.1080/09273948.2020.1737142

Cited by 18 publications

(4 citation statements)

References 57 publications

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“…At the site of the typical acute toxoplasmic retinochoroidal lesion, OCTA usually depicts attenuation of the retinal microvasculature accompanied by underlying focal hypoperfusion of the choriocapillaris corresponding to the area of reactive choroidal inflammatory thickening. 41 During resolution, the inflammatory focus leading to obliteration progressively diminishes, eventually leaving various degrees of focal drop out of the choriocapillaris. OCTA is also able to display vascular occlusion and CNV as complications of OT.…”

Section: Resultsmentioning

confidence: 99%

Serous macular detachment in ocular toxoplasmosis: A review

Cirone

Pellegrini²,

Cuna³

et al. 2023

European Journal of Ophthalmology

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Ocular toxoplasmosis, a disease of the eye caused by the protozoan parasite Toxoplasma gondii, represents a common cause of posterior uveitis. The Authors review the current Literature regarding the uncommon presentation of ocular toxoplasmosis as macular serous retinal detachment (SRD). It is imperative to keep in mind that inflammatory SRD is a possible presentation of toxoplasmic retinochoroiditis. Underestimation of this clinical scenario and treatment with steroids alone without appropriate antiparasitic drugs, could lead to devastating consequences.

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Section: Resultsmentioning

confidence: 99%

Serous macular detachment in ocular toxoplasmosis: A review

Cirone

Pellegrini²,

Cuna³

et al. 2023

European Journal of Ophthalmology

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“…Here, we first adopted the ophthalmic imaging diagnostic technology, OCT examination, which can directly non-invasive assessment of intraocular lesion in living mice ( Cunningham et al., 2022 ). In the infection group, most of the mice developed severe vitreous, subretinal fluid, posterior vitreous detachment and disorder of retinal structure ( Chen et al., 2016 ; Brandao-de-Resende et al., 2020 ; Ksiaa et al., 2022 ), while the symptoms were relatively mild with LBH589 treatment. In addition, we set a drug dose gradient of 1 to 3 ng/μl based on the previous study about pharmacokinetics of LBH589 to avoid the toxicity of drugs to the retina ( Van Veggel et al., 2018 ; Karol et al., 2020 ; Homan et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo anti−Toxoplasma activities of HDAC inhibitor Panobinostat on experimental acute ocular toxoplasmosis

Zhang¹,

Li²,

Huang³

et al. 2022

Front. Cell. Infect. Microbiol.

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Ocular toxoplasmosis (OT) is retinochoroiditis caused by Toxoplasma gondii infection, which poses a huge threat to vision. However, most traditional oral drugs for this disease have multiple side effects and have difficulty crossing the blood-retinal barrier, so the new alternative strategy is required to be developed urgently. Histone deacetylases (HDAC) inhibitors, initially applied to cancer, have attracted considerable attention as potential anti-Toxoplasma gondii drugs. Here, the efficacy of a novel HDAC inhibitor, Panobinostat (LBH589), against T. gondii has been investigated. In vitro, LBH589 inhibited the proliferation and activity of T. gondii in a dose-dependent manner with low toxicity to retinal pigment epithelial (RPE) cells. In vivo, optical coherence tomography (OCT) examination and histopathological studies showed that the inflammatory cell infiltration and the damage to retinal architecture were drastically reduced in C57BL/6 mice upon treatment with intravitreal injection of LBH589. Furthermore, we have found the mRNA expression levels of inflammatory cytokines were significantly decreased in LBH589–treated group. Collectively, our study demonstrates that LBH589 holds great promise as a preclinical candidate for control and cure of ocular toxoplasmosis.

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“…The most common cause is ingestion of undercooked meat or water with oocytes. 1 , 2 , 3 Infections may be asymptomatic. However, ocular symptoms can occur as a result of initial infection or reactivation of previous infection.…”

Section: Diagnosis: Toxoplasmosis Chorioretinitismentioning

confidence: 99%

“…Toxoplasmosis chorioretinitis is one of the most frequent causes of infectious uveitis affecting the posterior segment of the eye, which can cause severe vision loss. The most common cause is ingestion of undercooked meat or water with oocytes 1–3 . Infections may be asymptomatic.…”

Section: Diagnosis: Toxoplasmosis Chorioretinitismentioning

confidence: 99%