Multimodal management — of value in fulminant acute pancreatitis?

Haraldsen, Pernille; Sun, Zhengwu; Börjesson, Anna; Olanders, Knut; Lasson, Åke; Andersson, Roland

doi:10.1159/000069148

Cited by 10 publications

(5 citation statements)

References 69 publications

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“…Their results support this thesis. In the other recently reported study from Haraldsen et al [35] , combination therapy with NAC and monoclonal antibody against platelet endothelial cell adhesion molecule on the sodium taurocholat induced pancreatitis in rats may offer effectiveness on the multiorgan failure during severe acute pancreatitis.…”

Section: Discussionmentioning

confidence: 90%

Effects of N-Acetylcysteine on Acute Necrotizing Pancreatitis in Rats

Mumcu¹,

Alhan²,

Türkyılmaz³

et al. 2005

Eur Surg Res

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The aim of this study was to investigate the influence of N-acetylcysteine (NAC) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. The induction of ANP resulted in significant increase in mortality rate, pancreatic necrosis and serum activity of amylase, alanine aspartate transferase (ALT), interleukin-6 (IL-6), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, tissue activity of myeloperoxidase (MPO) and malondialdehyde (MDA) in the pancreas and lung, and significant decrease of concentrations of calcium, blood pressure, urine output and pO₂. The use of NAC inhibited the changes in urine output, pO₂, tissue activity of MPO and MDA in pancreas and lungs, and the serum activity of IL-6, ALT, and serum concentrations of urea and calcium. NAC reduced the mortality and pancreatic damage. The use of NAC has a beneficial effect on the course of ANP in rats. It may be used in the treatment of acute pancreatitis.

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Section: Discussionmentioning

confidence: 90%

Effects of N-Acetylcysteine on Acute Necrotizing Pancreatitis in Rats

Mumcu¹,

Alhan²,

Türkyılmaz³

et al. 2005

Eur Surg Res

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“…The complexity of underlying pathophysiological mechanisms in acute pancreatitis, especially when complicated by MODS, is profound. Despite this, the key role of ROS makes broad acting antioxidants potentially interesting, at least as a part of a multimodal treatment therapy [79] .…”

Section: Intracellular Signalsmentioning

confidence: 99%

Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction

et al. 2005

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“…Fulminant acute pancreatitis is more dangerous [1] . Severe acute pancreatitis (SAP), characterized by intricate mechanism, variant symptoms, grave prognosis and multiple complications, seriously threatens the life of patients and brings a heavy burden to the society, families and economy.…”

Section: Introductionmentioning

confidence: 99%

Effect of severe acute pancreatitis on pharmacokinetics ofDa-Cheng-Qi Decoction components

Gong¹,

Tang²,

Yu³

et al. 2009

WJG

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AIM:To investigate the effect of severe acute pancreatitis (SAP) on pharmacokinetics of Da-Cheng-Qi Decoction (DCQD) components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group (n = 6). Rhein, chrysophanol, rheochrysidin, magnolol, hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage. The Cmax (chrysophanol, P = 0.0059; rheochrysidin, P = 0.0288; magnolol, P = 0.0487; hesperidin, P = 0.0277; naringin, P = 0.0023) and AUC (rhein, P = 0.0186; chrysophanol, P = 0.0013; magnolol, P = 0.001; hesperidin, P = 0.0081; naringin, P = 0.0272) of DCQD component were obviously lower in SAP group than in control group. The T1/2α of chrysophanol and rheochrysidin (P = 0.0467 and 0.0005, respectively) and Tmax of chrysophanol and rheochrysidin (P = 0.0101 and 0.0037, respectively) lasted longer in SAP group than in control group. CONCLUSION:

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Multimodal management — of value in fulminant acute pancreatitis?

Cited by 10 publications

References 69 publications

Effects of N-Acetylcysteine on Acute Necrotizing Pancreatitis in Rats

Effects of N-Acetylcysteine on Acute Necrotizing Pancreatitis in Rats

Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction

Effect of severe acute pancreatitis on pharmacokinetics ofDa-Cheng-Qi Decoction components

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