2022
DOI: 10.1186/s40779-022-00376-1
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Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury

Abstract: Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism, the treatment of this disease still faces a huge challenge. Hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord. Hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that h… Show more

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Cited by 33 publications
(26 citation statements)
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“…Neuroplasticity can also manifest in the central nervous system post-injury via the mechanism of cortical remapping, where functions lost as a result to CNS damage is remapped to another part of the cerebral cortex [55]. In the repair of spinal cord injury, hydrogels have mechanical properties that mimic the extracellular matrix of the spinal cord, providing a scaffold for axonal growth and neuronal formation, removal of inflammatory cells and factors, eliminating spinal cord cyst formation, and inhibition of glial scarring [56]. Advances in organ regeneration and healing can revolutionize treatment modalities and optimise patient care.…”
Section: Advances In Organ Regenerationmentioning
confidence: 99%
“…Neuroplasticity can also manifest in the central nervous system post-injury via the mechanism of cortical remapping, where functions lost as a result to CNS damage is remapped to another part of the cerebral cortex [55]. In the repair of spinal cord injury, hydrogels have mechanical properties that mimic the extracellular matrix of the spinal cord, providing a scaffold for axonal growth and neuronal formation, removal of inflammatory cells and factors, eliminating spinal cord cyst formation, and inhibition of glial scarring [56]. Advances in organ regeneration and healing can revolutionize treatment modalities and optimise patient care.…”
Section: Advances In Organ Regenerationmentioning
confidence: 99%
“…Studies have shown that using such carriers for transplanting neural stem/progenitor cells effectively promotes behavioral recovery in SCI rats ( Mothe et al, 2013 ). Hydrogels can be used as slow-release small-molecule drug reservoirs ( Wang et al, 2022 ). For instance, serpin delivered by a chitosan-collagen hydrogel demonstrated a prolonged therapeutic effect and facilitated functional recovery in SCI rats ( Kwiecien et al, 2020 ).…”
Section: Approaches For Spinal Cord Injury Treatmentmentioning
confidence: 99%
“…Primary spinal cord injury resulting in axonal disruption, neural tissue destruction and neuronal death, with partial functional repair primarily through surgical decompression and spinal fixation (Antar et al, 2018;Huang et al, 2022). Secondary injuries are long-term progressive injuries that occur after the primary injury resulting in lesion spread and stage destruction, including neuronal/axonal loss, formation of a neuroregenerative inhibitory microenvironment and glial scarring (Doherty et al, 2002;Wang et al, 2022). However, the death of motor neurons, interneurons, and glial cells at the site of the lesion owing to subsequent damage predisposes to a decrease in muscle tissue mass and fiber cross-sectional fiber diameter, resulting in a loss of function (Liu X. et al, 2021;Fouad et al, 2021).…”
Section: Introductionmentioning
confidence: 99%