Multimodale Therapie bei NSCLC

Abstract

Behandlung und Prognose des nicht kleinzelligen Bronchuskarzinoms (NSCLC) sind abhängig vom Tumorstadium des Patienten. Das mediastinale Lymphknotenstaging ist entscheidend, um die optimale Th erapiestrategie festzulegen. Ein ipsilateraler mediastinaler Lymphknotenbefall (N2) bedeutet zumindest ein Stadium IIIA, in dem ein multimodales Th erapiekonzept mit Induktionschemotherapie bzw. -chemoradiotherapie mit nachfolgender Operation bei entsprechendem Downstaging das etablierte Standardverfahren ist. Die Identifi kation derjenigen Patienten, die bei operablem Primärtumor von einer Induktionstherapie profi tieren, ist eine der Herausforderungen des mediastinalen Stagings.

Multiphoton Lithography as a Promising Tool for Biomedical Applications

“…[ 199 ] The technology of holographic 2PP was patented and commercialized for the generation of tissue models by Prellis biologics, which was founded in 2016. [ 200–202 ]…”

“…[199] The technology of holographic 2PP was patented and commercialized for the generation of tissue models by Prellis biologics, which was founded in 2016. [200][201][202] While multifocus 2PP can be an interesting approach to create periodic structures, the movement of these multiple focal spots remains dependent on the mechanical equipment of the system. [198] In this respect, a significant increase in performance was achieved via the incorporation of galvo mirrors in multiphoton lithography, resulting in writing speeds up to 5 m s −1 as first reported by researchers of TU Wien (Austria) in 2012.…”

“…[198] In this respect, a significant increase in performance was achieved via the incorporation of galvo mirrors in multiphoton lithography, resulting in writing speeds up to 5 m s −1 as first reported by researchers of TU Wien (Austria) in 2012. [202,203] This technology was commercialized for the first time in 2013 by Nanoscribe with the launch of the Professional GT system. [204] However, while maximum speeds exceeding a few meters per second could be obtained, the total writing speed remained limited by additional aspects related to the technology.…”