Multimodality Local Therapy for Retroperitoneal Sarcoma

Abstract

2016-12-24T18:13:07

The Benefit of Adjuvant Radiotherapy in High-grade Nonmetastatic Retroperitoneal Soft Tissue Sarcoma

“…32 An earlier single-institution series showed that margin status was the only significant prognostic factor for 5-year OS, suggesting improving LC is likely related to improved OS. 33 These conclusions are consistent with previously mentioned SEER analyses of patients with STS of the extremities in which RT is only associated with an OS benefit to patients with high-grade disease. 21,22 This agrees with a prior SEER report of all patients with RPS, irrespective of tumor grade, which showed that adjuvant RT was associated with an increase in OS only in patients with malignant fibrous histiocytoma (although it should be noted that, in 2002, the World Health Organization declassified malignant fibrous histiocytoma and replaced it with high-grade undifferentiated pleomorphic sarcoma).…”

A retrospective, single‑center cohort study on 65�patients with primary retroperitoneal liposarcoma

“…The majority of patients with PRPLS are diagnosed at an advanced disease stage, therefore PRPLS tumors often grow to a large size and have invaded adjacent organs upon diagnosis (22). The benefits of using adjuvant chemotherapy and radiation therapy to treat PRPLS remains controversial (23,24). A number of studies have suggested that chemotherapy may worsen patient prognosis (25,26).…”

“…A number of studies have suggested that chemotherapy may worsen patient prognosis (25,26). Other studies have reported that chemotherapy has limited effectiveness for PRPLS, but is beneficial for liposarcomas originating from the lower or upper extremities (23,27). Radiation can result in clinical complications, including nerve lesions, hydronephrosis, ureteral fistula and ileus (28).…”

Spatial and volumetric changes of retroperitoneal sarcomas during pre-operative radiotherapy

“…Unlike STS from the extremities in which approximately 90% local control is achieved largely through wide excision ± adjuvant radiotherapy (RT), the 5-year local control rate in RPS from surgical series ranges from 30 to 50% [2] and locoregional abdominal failure is the principle cause of death [3][4][5][6][7][8][9][10][11]. Efforts to improve local control in RPS have included the use of pre-operative RT (PreRT) [12][13][14]. This strategy produced 5 and 10-year relapse free survival rates of 69% and 63% respectively, in a Princess Margaret Cancer Centre (PMH)/Mt-Sinai Hospital Phase I/II study and has been adopted as standard practice at the PMH [15].…”