As higher density of interconnects and packages are demanded, crosstalk noise is becoming more important in input/output (I/O) design. The multimode signaling scheme offers effective crosstalk cancellation in high density links. This paper presents a new circuit/channel co-design methodology for high density links with multimode signaling. A detailed design approach is introduced and a detailed channel design optimization example is provided to validate this method. The optimized channel shows over 60% root mean square (RMS) jitter reduction compared with singleended signaling. The printed circuit board (PCB) and package routing density of the optimized channel are 300% and 97% higher compared with a practical benchmark channel, respectively, and still shows 31% jitter reduction.