Multinodular goitre arising in the tracheal lumen: implantation or ectopic?

Love, Rachelle L.; Ahsan, Farhan; Allison, R. S.; Keast, Allan; Lambie, Neil

doi:10.1017/s0022215111002544

Cited by 3 publications

(2 citation statements)

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“…1); two were excluded for not being reported in English, 71 were excluded because of lacking detailed information, two were excluded because being redundant older reports of the same patient, and one was a report of a patient with thyroid cancer with tracheal invasion. Of the remaining 38 reports, all have orthotopic thyroid glands which could be distinguished from “ectopic thyroid.” A summary of the clinical details of the 38 ITT patients are shown in Table I 1,2,4–39 …”

Section: Resultsmentioning

confidence: 99%

“…Of the remaining 38 reports, all have orthotopic thyroid glands which could be distinguished from “ectopic thyroid.” A summary of the clinical details of the 38 ITT patients are shown in Table I . 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 …”

Section: Resultsmentioning

confidence: 99%

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Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports

Brooks

Iwata

et al. 2021

The Laryngoscope

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Objective/Hypothesis To examine the clinical features of benign intratracheal thyroid (ITT) and their management strategies and outcomes. Study Design Case series study. Methods This systemic review was conducted in two international academic centers. This review includes 43 patients: one new case from the Massachusetts Eye and Ear Infirmary, four new cases from Beijing Tongren Hospital, and 38 previously published cases. We analyzed these 43 cases and summarized the patients' epidemiological data, clinical features, and treatment regimens. Results ITTs were less common in men than in women (male:female ratio of 3:10). ITT was observed in patients as young as neonates and as old as 85 years. Orthotopic thyroid nodules were present in 55.8% of the patients with ITT. Malignancy was incidentally found in 4.6% of all ITTs. Imaging examinations showed that the ITTs were typically attached to the posterolateral/lateral tracheal wall of the first, second, or third tracheal rings. Tissue attachment between the ITT and normal thyroid lobes was seen in 59.5% of the patients. Thirty‐seven patients underwent surgery: 30 underwent open surgery, and seven underwent endoscopic debulking resections. One neonate received thyroid suppression therapy. One patient with ITT and papillary thyroid cancer was treated with radiotherapy and ultimately died after recurrence. Conclusions Surgical resection is an effective treatment for benign ITT. We hypothesized that abnormalities during the embryonic development of Berry's ligament might play a role in ITT pathogenesis. Level of Evidence NA Laryngoscope, 131:E2609–E2617, 2021

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports

Brooks

Iwata

et al. 2021

The Laryngoscope

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Secondary tracheal tumors: a systematic review

Madariaga¹,

Gaissert²

2018

Ann. Cardiothorac. Surg.

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Background: Secondary tracheal tumors arise from mural invasion by primary tumors in adjacent organs, metastatic lymph nodes or blood-born metastasis from distant sites. This systematic review aims to assess the presentation, management options, and clinical outcomes of these uncommon non-tracheal malignancies.Methods: Electronic searches of the MEDLINE database were performed to identify case series and individual case reports of tracheal invasion by primary non-tracheal tumors or metastatic disease. AllEnglish-language studies with available abstracts or articles containing primary data were included.Results: From 1978 to 2017, a total of 160 case reports or case series identified 2,242 patients with invasion of the trachea by tumors of adjacent organs (n=1,853) or by metastatic lymph nodes or hematogenous spread (n=389). Common primary sites of origin were thyroid, esophagus, and lung, and the most common presentation was metachronous (range of interval: 0 to 564 months) with dyspnea, neck mass, voice change and/or hemoptysis. A majority of patients in case reports (77.9%) and case series (66.0%) underwent resection and the most common reported operation was segmental tracheal resection. Fewer patients underwent bronchoscopic intervention (21.7%) and radiation was used in 32.2% of patients. Complications after bronchoscopic treatment included bleeding, granulation tissue, and retained secretions, while anastomotic leak, unplanned tracheostomy, and new recurrent laryngeal nerve paralysis were observed after surgical resection. The rate of 30-day mortality was low (0.01-1.80%). Median survival was higher in patients with thyroid malignancy and in patients who underwent surgical management. Follow-up time ranged from 0.03 to 183 months. Conclusions:Patients with tracheal invasion by metastatic or primary non-tracheal malignancies should be assessed for symptoms, tumor grade, tumor recurrence and concurrent metastases to decide on optimal surgical, bronchoscopic or noninterventional therapy. Clinical experience suggests that palliative endoscopic intervention for tracheal obstruction by metastasis-bearing lymph nodes is underreported.Keywords: Endotracheal metastasis; secondary tracheal tumors; systematic review Submitted Nov 24, 2017. Accepted for publication Dec 21, 2017Dec 21, . doi: 10.21037/acs.2018 View this article at: http://dx.doi.org/10.21037/acs.2018.02.01 Systematic Review IntroductionSecondary tracheal tumors are defined as tumors in, but not of the trachea and comprise a wide spectrum of tumor histologies and stages. There are no populationbased data for these tumors, and in clinical practice these lesions are probably more common than primary neoplasms. A thoracic surgeon probably encounters tracheal obstruction by metastatic lymph nodes more often than invasion by adjacent primary tumors. Since natural history and prognosis are related to the tumor of origin, their management and prognosis may differ considerably from primary tracheal neoplasms; a correct diagnosis with attribution to the origi...

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Multi-nodular Goiter with Intra-tracheal Thyroid Tissue: Ectopic or Implanted? And Ectopic Nasopharyngeal Thyroid Tissue: A Case Report

Jabbr¹,

Kassouma²,

Salman³

et al. 2015

Otolaryngol (Sunnyvale)

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Multinodular goitre arising in the tracheal lumen: implantation or ectopic?

Abstract: Intra-operative thyroid tissue implantation in the trachea and subsequent goitre development has not previously been described. This case illustrates the need for careful resection of the thyroid in order to maintain the integrity of normal anatomical structures.

Cited by 3 publications

References 14 publications

Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports

Benign Intratracheal Thyroid: A Systematic Review of 43 Cases With Five New Case Reports

Secondary tracheal tumors: a systematic review

Multi-nodular Goiter with Intra-tracheal Thyroid Tissue: Ectopic or Implanted? And Ectopic Nasopharyngeal Thyroid Tissue: A Case Report

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