Multinuclear 1D and 2D NMR Investigations on the Interaction between the Pyrimidic Nucleotides 5′-CMP, 5′-dCMP, and 5′-UMP and Diethyltin Dichloride in Aqueous Medium

Supramolecular self-assembly of nucleotide–metal coordination complexes: From simple molecules to nanomaterials

“…Multinuclear complexes can also be generated from diethyltin dichloride and vanadium ions with nucleotide ligands. As mentioned in section 2.2, these multinuclear complexes exhibit structural variation based on pH control [47,49].…”

“…They exhibit good affinity for high valence metal ions in basic conditions (pH = 8.5-12), such as VO 2+ , UO 2 2+ , Sn 4+ , Sb 5+ , and Sb 3+ [44,45,[47][48][49].…”

“…Similar to 5-ADP, the initial macrochelation of the 5-GDP-Ru(II)(µ 6 -C 6 H 6 ) system also leads to rapid cleavage of the terminal β-phosphate. As shown by investigations using multinuclear 1D and 2D NMR techniques, including 119 Sn, 15 N, and 31 P nuclei, there is A c c e p t e d M a n u s c r i p t 10 competition between oxygen in the phosphate groups and hydroxyl groups of pentose in the compounds diethyl-tin dichloride with 5-CMP, 5-dCMP, and 5-UMP [47]. Each tin atom is linked to a phosphate group of 5-CMP in the pH range of 0.5 to 3.5.…”

Synthesis, Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin(IV) Complexes Derived from Aminoalcohols

“…However, recent studies have shown that at low pH values Sn(IV) interacts with the phosphate groups of the DNA forming Sn-O bonds. [24][25][26] Additionally, compounds 2a-d were also tested against MT2 cells (human T-lymphocytes). In general, IC 50 values determined for MT2 cells are higher than those found for cancer cell lines (Table 2), which means that this type of compounds exhibit certain selectivity towards cancer cell lines, except for compound 2d.…”

Synthesis, structural characterization and biological study of new organotin(IV), silver(I) and antimony(III) complexes with thioamides

“…(i) Since it is known that nucleotides like 5 0 -CMP, 5 0 -dCMP, 5 0 UMP and 5 0 -IMP and 5 0 GMP react with organotin(IV) complexes at pH < 4 through the phosphates and at pH > 9.5 through the oxygen atoms of the sugar units [33,34], at physiological pH values, the antitumor action of organotins(IV), should not involve reaction with DNA. The enzyme LOX and COX inhibiting capacity of the organotin(IV) complexes may be the cause of their antitumor activity and not their interaction with DNA.…”