Multinuclear Magnetic Resonance Imaging and NMR Spectroscopy in Biomedical Investigations

Pirogov, Y.A.

doi:10.1016/j.phpro.2016.05.002

Cited by 5 publications

(6 citation statements)

References 3 publications

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“…3 Also other NMR active nuclei such as 13 C, 19 F or 31 P can be detected by MRI. 4,5 Among them, 19 F is of special interest as its gyromagnetic momentum is close to that of 1 H which enables detection of 19 F NMR signals on proton MRI scanners with only small hardware and software modifications. Furthermore, fluorine is a monoisotopic element and has almost no abundance in living organisms which predisposes it for use in "hotspot" imaging.…”

Section: Introductionmentioning

confidence: 99%

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for ¹⁹F magnetic resonance imaging

Koucký¹,

Kotek²,

Cı́sařová³

et al. 2023

Dalton Trans.

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Section: Introductionmentioning

confidence: 99%

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for ¹⁹F magnetic resonance imaging

Koucký¹,

Kotek²,

Cı́sařová³

et al. 2023

Dalton Trans.

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“…diagnosis, treatment monitoring and prognosis evaluation of many diseases, such as cancers. 3 It has been documented that many atom nuclei can be used in MRI, such as 1 H, 2 H, 11 B, 13 C, 19 F, 23 Na, 31 P, and 129 Xe, 4 among which 1 H-based MRI is the most prevalent imaging technique in clinical practice and biomedical research. The high sensitivity and abundance of 1 H lead to strong signals in 1 H MRI, thus offering precise anatomical and pathological information.…”

Section: Xueni Zhangmentioning

confidence: 99%

Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases

Wang

Zhang

et al. 2022

J. Mater. Chem. B

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“…The color scale corresponds to the SNR values in 19 F MRI images. The images were obtained in 7 T scanner [ 3 – 5 ] …”

Section: The Most Suitable For This Application Are Substances Containing Fluorine-19 Atoms ( 19 F)mentioning

confidence: 99%

“…Secondly, the required for measurements hyperpolarization state does not last long, for several minutes at best. Therefore, we tasked ourselves with finding such methods of multinuclear MRI diagnostics that would allow, without the use of hyperpolarization, to obtain in limited time clear MRI images of human and animal internal organs and tissues [ 1 – 3 ].…”

Section: Introductionmentioning

confidence: 99%

Multinuclear MRI Research

Pirogov

2021

Appl Magn Reson

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The presented data clearly demonstrate that multinuclear MRI has a great potential in research and clinical fields. The biomedical value of many heavy nuclei that are part of drugs, contrast agents, and molecular complexes in live tissues emphasizes the need for creating and using MRI scanners tuned to the Larmor frequencies of such nuclei. This article discusses a number of specific problems solved with the use of multinuclear MRI. Since the sensitivity of the MRI on heavy nuclei, as a rule, is insufficient for obtaining images of satisfactory quality, it is proposed to use hyperpolarization techniques for preparing objects for the MRI diagnostics. However, bearing in mind the high cost of hyperpolarization techniques, alternative approaches using contrast agents normally absent in tissues can be more suitable in certain situations. For instance, due to the absence of fluorine in the body, 19 F MRI allows for successful diagnostics of the respiratory tract and lungs filled with fluorine-containing gas, detecting the location of the blood substitute Perftoran® in the body, monitoring the transport along the gastrointestinal tract of a capsule filled with a preparation containing fluorine-19 nuclei, etc. The possibility of non-invasive local measurements of the concentration of sodium-23 in the body, which, in case of a deviation from the norm, is linked to such pathologies as diabetes, hypertension, renal failure, and many others, is also demonstrated. Reported as well is the creation of transmitting and receiving infrastructure that makes possible effective MRI measurements at low fields (of about 0.5 T) at 10 Larmor frequencies corresponding to the nuclei of hydrogen, deuterium, fluorine, boron, chlorine, sodium, carbon, phosphorus, silicon and oxygen.

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Multinuclear Magnetic Resonance Imaging and NMR Spectroscopy in Biomedical Investigations

Cited by 5 publications

References 3 publications

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for ¹⁹F magnetic resonance imaging

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for ¹⁹F magnetic resonance imaging

Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases

Multinuclear MRI Research

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Multinuclear Magnetic Resonance Imaging and NMR Spectroscopy in Biomedical Investigations

Cited by 5 publications

References 3 publications

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for 19F magnetic resonance imaging

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for 19F magnetic resonance imaging

Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases

Multinuclear MRI Research

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Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for ¹⁹F magnetic resonance imaging

Transition metal complexes of cyclam with two 2,2,2-trifluoroethylphosphinate pendant arms as probes for ¹⁹F magnetic resonance imaging