Multinucleated giant cell appearance after whole body microwave irradiation of rats

Trošić, Ivančica

doi:10.1078/1438-4639-00078

Cited by 16 publications

(3 citation statements)

References 9 publications

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“…Studies by Ivana et al in 2004 suggest that it may be possible to reduce the number of WBCs and their percentage to reduce the precursor cells in the bone marrow, which contradicts the results of this study [14][15][16][17]. In some studies, it was found that electromagnetic fields resulted in increase the number of WBCs and their percentage (lymphocytes, monocytes, neutrophils, eosinophils, basophils), with increase the total number of white blood cells consistent with the result of this research, but increase in the percentage of its types contradicts this research.…”

Section: B Meancontrasting

confidence: 98%

Evaluating effects of electromagnetic fields on the total number and percentage of white blood cells in mice

Laein¹,

Hormozi²,

Ali³

et al. 2021

JCRCT

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To evaluate the effects of electromagnetic waves on the total number and percentage of white blood cells and also antioxidant effects of vitamin C on the effects radiation, 24 male mice (Balb/c) were used: control under the influence of low frequency electromagnetic waves and under the influence of waves with vitamin C. Total number of white blood cells in under the influence waves group significantly increased compared to control group, and also under the influence waves group with vitamin C because its antioxidant property is able to prevent the increasing impact of electromagnetic waves. The percentage of white blood cells in the under influence waves group did not significantly change compared to the control group and also, the under influence waves group with vitamin C had no significant change compared to the other group. The percentage of neutrophils in samples of the under influence waves group had significant decrease compared to control group but in the under influence waves group with vitamin C compared to the other group, this vitamin C could prevent a significant reduction in percentage of neutrophils. Our findings indicated that low electromagnetic fields have caused significant changes in the total number of white blood cells and percentage of neutrophils in mice. In the group that received vitamin C injection, significant changes were observed in the total number of white blood cells and percentage of neutrophils relative to the group under the influence of low electromagnetic waves, which indicates that vitamin C could restore the mean total number of white blood cells and percentage of neutrophils to normal value.

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Section: B Meancontrasting

confidence: 98%

Evaluating effects of electromagnetic fields on the total number and percentage of white blood cells in mice

Laein¹,

Hormozi²,

Ali³

et al. 2021

JCRCT

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“…However, RF radiation was found to interact with different apoptosis pathways in living cells ( 7 , 8 , 9 ). A number of studies have also investigated its genotoxic and other effects on the cell cycle, enzyme activity, gene expression, DNA, oxidative stress, and chromosomes ( 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ).…”

mentioning

confidence: 99%

Microtubular structure impairment after GSM-modulated RF radiation exposure

Čermak

Ilić

Pavičić

2020

Archives of Industrial Hygiene and Toxicology

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The objective of the study was to investigate whether low-level 915 MHz GSM-modulated radiofrequency (RF) radiation impairs microtubular structure and affects normal cell growth. V79 cells were exposed to a GSM-modulated field in a Gigahertz Transversal Electromagnetic Mode cell (GTEM cell) for 1, 2, and 3 h. Signal generator combined with power and chip modulator generated the electromagnetic field (EMF). The electric field strength was adjusted to 10, 20, and 30 V/m, and the average specific absorption rate (SAR) was calculated to be 0.23, 0.8, and 1.6 W/kg. The structure of microtubule proteins was assessed by indirect immunocytochemistry, and cell growth was determined based on cell counts taken every day over six post-exposure days. Three-hour radiation exposure significantly altered microtubule structure regardless of the electric field strength. Moreover, on the third post-exposure day, three-hour radiation significantly reduced cell growth, regardless of field strength. The same was observed with two-hour exposure at 20 and 30 V/m. In conclusion, 915 MHz GSM-modulated RF radiation affects microtubular proteins in a time-dependent manner, which, in turn, affects cell proliferation. Our future research will focus on microtubule structure throughout the cell cycle and RF radiation effects on mitotic spindle.

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“…Blood leukocyte and lymphocyte counts remained within the normal range observed in control animals (22). This response to radiation-induced stress in the bloodforming system provoked by the irradiation suggests that the changes are rather a sign of adaptation than of malfunction (23).…”

Section: Rf/mw Influence On the Haematopoiesis In Ratsmentioning

confidence: 84%

Non-Thermal Biomarkers of Exposure to Radiofrequency/Microwave Radiation

Trošić¹,

Pavičić²,

Marjanović³

et al. 2012

Archives of Industrial Hygiene and Toxicology

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This article gives a review or several hypotheses on the biological effects of non-thermal radiofrequency/ microwave (RF/MW) radiation and discusses our own fi ndings from animal and in vitro studies performed over the last decade. We have found that RF/MW radiation disturbs cell proliferation and leads to cell differentiation in the bone marrow, which is refl ected in the peripheral blood of rats. Repeated RF/MW radiation can also temporarily disrupt melatonin turnover. The observed changes seem to be a sign of adaptation to stress caused by irradiation rather than of malfunction. The article looks further into the basic mechanisms of RF/MW biological action, including cell growth parameters, colony-forming ability, viability, and the polar and apolar protein cytoskeleton structures. The observed reversible cell changes signifi cantly obstructed cell growth. In contrast to the apolar intermediate proteins, the intracellular polar microtubule and actin fi bres were damaged by radiation in a time-dependent manner. These signifi cantly altered parameters can be considered as the biomarkers of exposure. Future research should combine dosimetry, experimental studies, and epidemiological data.

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Multinucleated giant cell appearance after whole body microwave irradiation of rats

Cited by 16 publications

References 9 publications

Evaluating effects of electromagnetic fields on the total number and percentage of white blood cells in mice

Evaluating effects of electromagnetic fields on the total number and percentage of white blood cells in mice

Microtubular structure impairment after GSM-modulated RF radiation exposure

Non-Thermal Biomarkers of Exposure to Radiofrequency/Microwave Radiation

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