Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming

Marathe, Soumitra; Dhamija, Bhavuk; Kumar, Sushant; Jain, Nikita; Ghosh, Sarbari; Dharikar, Jai Prakash; Srinivasan, S.; Das, Somnath; Sawant, Abhijeet; Desai, Saloni Abhijit; Khan, Farhat Ali; Syiemlieh, Abigail; Munde, Manohar; Narasimhan, Chitra; Gandhi, Mayuri N.; Kumar, Ashutosh; Srivastava, Sanjeeva; Venkatesh, K. V.; Barthel, Steven R.; Purwar, Rahul

doi:10.1016/j.jid.2021.02.013

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…In addition, Th17 cells, Th9 cells, type 2 innate lymphoid (ILC2s), and mast cells are suggested to participate in pathological cutaneous foci as IL-9 producers (Lozano-Ojalvo et al, 2019;Nowak et al, 2009;Rauber et al, 2017;Schlapbach et al, 2014). Given that IL-9 regulates the metabolic reprogramming of human keratinocytes (Marathe et al, 2021) and IL-9R is highly expressed in keratinocytes in atopic dermatitis (Hong et al, 2015), IL-9 may play a certain role in unresolved skin inflammation. However, the interplay between keratinocytes and other cells in inflammatory skin lesions is complex.…”

Section: Introductionmentioning

confidence: 99%

Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation

Kamiya

Ikegami

Yanagi

et al. 2022

Journal of Investigative Dermatology

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Section: Introductionmentioning

confidence: 99%

Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation

Kamiya

Ikegami

Yanagi

et al. 2022

Journal of Investigative Dermatology

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“…Multi-omics data confirmed increased glucose consumption and IL9-mediated redirection of metabolic flux towards lactate, with a subsequent reduction of tricarboxylic acid (TCA) cycle intermediates in HPKs [ 72 ]. Ilves and co-authors recently demonstrated increased levels of putrescine, dimethylarginine, acetyl-L-carnitine, glutamate, methionine, and sphingolipidsin atopic skin [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Current Knowledge in Skin Metabolomics: Updates from Literature Review

Paganelli

Righi

Tarentini³

et al. 2022

IJMS

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Metabolomic profiling is an emerging field consisting of the measurement of metabolites in a biological system. Since metabolites can vary in relation to different stimuli, specific metabolic patterns can be closely related to a pathological process. In the dermatological setting, skin metabolomics can provide useful biomarkers for the diagnosis, prognosis, and therapy of cutaneous disorders. The main goal of the present review is to present a comprehensive overview of the published studies in skin metabolomics. A search for journal articles focused on skin metabolomics was conducted on the MEDLINE, EMBASE, Cochrane, and Scopus electronic databases. Only research articles with electronically available English full text were taken into consideration. Studies specifically focused on cutaneous microbiomes were also excluded from the present search. A total of 97 papers matched all the research criteria and were therefore considered for the present work. Most of the publications were focused on inflammatory dermatoses and immune-mediated cutaneous disorders. Skin oncology also turned out to be a relevant field in metabolomic research. Only a few papers were focused on infectious diseases and rarer genetic disorders. All the major metabolomic alterations published so far in the dermatological setting are described extensively in this review.

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“…Therefore, we examined the roles of IL-9/IL-9R interaction in regulating the IFNγinduced toxic ROS production in melanocyte. HPMs were stimulated with cytokines (IL-9, 20 ng/ml and IFNγ, 10 ng/ml) for overnight at 37°C with 5% CO 2 , and ROS levels were quantified by flowcytometry upon staining with 1 µM 2, 7-dichlorodihydrofluorescein diacetate (H 2 DCF-DA; Sigma-Aldrich) (Marathe et al, 2021). Interestingly, IFNγ increased the ROS level in HPMs and IL-9 reduced the IFNγ-induced ROS in HPMs (Figure 3c,d; n = 3, p =.026).…”

Section: Significancementioning

confidence: 99%

Presence and the roles of IL‐9/Th9 axis in vitiligo

Kumar

Marathe

Dhamija

et al. 2021

Pigment Cell Melanoma Res

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Vitiligo is an acquired idiopathic depigmentation disorder where selective damage of functional melanocytes causes hypo-pigmentation of the skin, hair, and mucosal surface (Ezzedine et al., 2015). The CD4 + and CD8 + T cells are described to be present at the junction of epidermis and dermis near the lesional skin of vitiligo, and the cytotoxic T cells are reported to kill melanocytes in vitiligo, emphasizing the roles of T cell-mediated immunity in vitiligo pathogenesis (van den Boorn et al., 2009). Recognizing imbalanced and dysfunctional effector T-cell subsets as well as dysregulated cytokine production might harbor significant potential for the targeted therapy. In addition, there are many indistinct facts about the loss of self-tolerance and dysregulated cytokine production in vitiligo pathogenesis.

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Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming

Cited by 10 publications

References 47 publications

Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation

Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation

Current Knowledge in Skin Metabolomics: Updates from Literature Review

Presence and the roles of IL‐9/Th9 axis in vitiligo

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