Multiparameter rodent chronic model for complex evaluation of alcoholism-mediated metabolic violations

Shayakhmetova, Ganna M.; Bondarenko, Larysa; Коваленко, В. М.; Kharchenko, O.; Bohun, Larisa I.; Omelchenko, Yuliya O.

doi:10.1515/jbcpp-2013-0163

Cited by 3 publications

(1 citation statement)

References 33 publications

(49 reference statements)

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“…Подобное снижение концентрации аминокислот также продемонстрировано в работах с хроническим воздействием больших доз ал-коголя (Jang et al, 2012;Shayakhmetova et al, 2015). При этом в ряде работ показано положительное влияние на метаболизм печени увеличения в рационе питания BCAA (Malaguarnera et al, 2009;Kato et al, 2013).…”

Section: Discussionunclassified

NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats

Крестина¹,

Шевелев²,

Коптюг³

et al. 2015

Vestn. VOGiS

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Section: Discussionunclassified

NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats

Крестина¹,

Шевелев²,

Коптюг³

et al. 2015

Vestn. VOGiS

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Opportunities of high-technology phenotyping by the NMR spectroscopy method by example of the metabolic response of the rat liver to the effect of alcohol and Reishi

Krestina

Shevelev

Koptyug

et al. 2016

Russ J Genet Appl Res

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The metabolic profiling of the rat liver was carried out in order to estimate the efficiency of proton nuclear magnetic resonance ( 1 H NMR) spectroscopy as a method of metabolomic phenotyping and a method of detecting early metabolic changes during toxic effects. The tissue samples were taken from three groups of rats: group C, control animals; group A, animals that repeatedly received 15% alcohol solution (its intake induced no pathological liver changes, but stimulated the proliferation of the hepatocytes); and group A + R, alcohol in combination with the plant hepatoprotective Reishi preparation (Ganoderma lucidum). As follows from the results obtained, the changes in the metabolite concentration in liver (observed in group A) reflected the typical metabolic reaction to the alcohol intake and were expressed in a decrease in the content of glycine, leucine, isoleucine, valine, choline, and lactate, as well as in an increase in the TMAO level. The concentration of glycine, valine, and TMAO was restored in the rats of group A + R during the Reishi intake. In addition, an increase in the concentrations of NAD, ATP, UTP, succinate, pyranose, and acetate was registered in group A + R relative to the control. Individual variations in the content of valine, isoleucine, leucine, lactate, choline, and pyranose is correlated to the number of binuclear hepatocytes (as an indicator of proliferative activity). Thus, the study of liver tissues by 1 H NMR spectroscopy method allows us to detect early deviations in the level of metabolites during chronic consumption of small alcohol doses and can be a promising approach both for diagnostic detection of alcoholic liver damage and for estimation of the efficiency of the applied drug therapy.

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Influence of Chronic Alcoholization of Rats on the Parameters of the Thiol-Disulphide System of the Brain and Search for New Pharmacotherapeutic Correction Schemes for Imbalance

Sokolik

Prozorova

2020

VPBM

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Multiparameter rodent chronic model for complex evaluation of alcoholism-mediated metabolic violations

Cited by 3 publications

References 33 publications

NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats

NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats

Opportunities of high-technology phenotyping by the NMR spectroscopy method by example of the metabolic response of the rat liver to the effect of alcohol and Reishi

Influence of Chronic Alcoholization of Rats on the Parameters of the Thiol-Disulphide System of the Brain and Search for New Pharmacotherapeutic Correction Schemes for Imbalance

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