Multiparametric classification of sub‐acute ischemic stroke recovery with ultrafast diffusion, ²³Na, and MPIO‐labeled stem cell MRI at 21.1 T

Abstract

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NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment

“…However, for spinecho acquisitions at 21.1T, recent studies have demonstrated that the presence of MPIO-labeled cells has minimal impact on the absolute diffusion coefficient. 38,39 Furthermore, the presence of MPIO contrast significantly decreases within the first 3 days, reaching a greater than 65% reduction by day 7. 27 Only animals with visually confirmed hMSC injections were included in the 2D hMSC group for the full study.…”

“…It should be noted that the presence of MPIO contrast in brain tissue at the early time points for the hMSC group might be considered to influence diffusion signals. However, for spin‐echo acquisitions at 21.1T, recent studies have demonstrated that the presence of MPIO‐labeled cells has minimal impact on the absolute diffusion coefficient 38,39 . Furthermore, the presence of MPIO contrast significantly decreases within the first 3 days, reaching a greater than 65% reduction by day 7 27 .…”