2019
DOI: 10.1002/nbm.4060
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Multiparametric MR for non‐invasive evaluation of tumour tissue histological characteristics after radionuclide therapy

Abstract: Early non‐invasive tumour therapy response assessment requires methods sensitive to biological and physiological tumour characteristics. The aim of this study was to find and evaluate magnetic resonance imaging (MRI) derived tumour tissue parameters that correlate with histological parameters and that reflect effects of radionuclide therapy. Mice bearing a subcutaneous human small‐intestine neuroendocrine tumour were i.v . injected with 177 Lu… Show more

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Cited by 11 publications
(10 citation statements)
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“…Since GOT1 cell proliferation is slow, most GOT1 animal studies are performed in the model based on serial transplantation of small tissue pieces from one tumor to several younger mice, which was the case in the present study. Due to some heterogeneity in GOT1 tumors [ 32 , 41 ], there is a risk that a mouse may be transplanted with a tumor piece having cells with altered SSTR expression, which was most probably the case in the present study, and explains the lower SSTR 2 expression in this non-responding mouse. We reported similar findings in a previous study [ 32 ].…”
Section: Discussionmentioning
confidence: 81%
“…Since GOT1 cell proliferation is slow, most GOT1 animal studies are performed in the model based on serial transplantation of small tissue pieces from one tumor to several younger mice, which was the case in the present study. Due to some heterogeneity in GOT1 tumors [ 32 , 41 ], there is a risk that a mouse may be transplanted with a tumor piece having cells with altered SSTR expression, which was most probably the case in the present study, and explains the lower SSTR 2 expression in this non-responding mouse. We reported similar findings in a previous study [ 32 ].…”
Section: Discussionmentioning
confidence: 81%
“…In the proposed algorithm, parameter maps are estimated from reconstructed images at each iteration, which provides an additional constraint on pixel values in the form of the relaxation model equation, in addition to information from the JTV, and improves the accuracy of the end results of the reconstruction process. Accelerated mpMRI parametric mapping will enable objective mapping of tissue histological characteristics [3][4][5]7,49 and intratumoral habitats, 6,[8][9][10]50 which in turn will enable the development of better imaging biomarkers for understanding tumor resistance to therapies and the development of adaptive anticancer therapy regimens. 41,42 Alternate approaches being investigated to this end include MR fingerprinting (MRF), which is a dictionary-based technique that is gaining popularity for accelerated acquisition of mpMR images in research settings.…”
Section: Resultsmentioning
confidence: 99%
“…Accelerated mpMRI parametric mapping will enable objective mapping of tissue histological characteristics 3–5,7,49 and intratumoral habitats, 6,8–10,50 which in turn will enable the development of better imaging biomarkers for understanding tumor resistance to therapies and the development of adaptive anticancer therapy regimens 41,42 . Alternate approaches being investigated to this end include MR fingerprinting (MRF), which is a dictionary‐based technique that is gaining popularity for accelerated acquisition of mpMR images in research settings.…”
Section: Discussionmentioning
confidence: 99%
“…The DWI-derived ADC is a quantitative parameter that can be used to evaluate properties of molecules, including cell density, cell membrane integrity, and interactions with macromolecules. Generally, ADC values are negatively related to cell density and positively related to extracellular space [ 25 ]. It has been proven that the ADC can reflect histological changes in primary tumors after neoadjuvant chemo-radiotherapy [ 26 ].…”
Section: Discussionmentioning
confidence: 99%