Multiparametric Prostate MR Imaging with T2-weighted, Diffusion-weighted, and Dynamic Contrast-enhanced Sequences: Are All Pulse Sequences Necessary to Detect Locally Recurrent Prostate Cancer after Radiation Therapy?

Donati, Olivio F.; Jung, Sung Il; Vargas, Hebert Alberto; Gültekin, David H.; Zheng, Junting; Moskowitz, Chaya S.; Hricak, Hedvig; Zeléfsky, Michael J.; Akın, Oğuz

doi:10.1148/radiol.13122149

Cited by 116 publications

(86 citation statements)

References 37 publications

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“…These results are comparable with our study, where sensitivity ranged between 0.85 and 0.97 with and 0.76 and 0.82 without the usage of an ERC, and demonstrate that images acquired without an ERC may be sufficient for the purpose of detection of prostate cancer. Inter- and intra-reader agreement in our study was within the range of previously published results [34,35,36,37] and did not differ between the two coil setups investigated.…”

Section: Discussionsupporting

confidence: 90%

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study

Barth¹,

Rupp²,

Cornelius³

et al. 2019

Current Urology

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Introduction: The purpose of this study was to compare diagnostic accuracy of a prostate multiparametric magnetic resonance imaging (mpMRI) protocol for detection of prostate cancer between images acquired with and without en-dorectal coil (ERC). Materials: This study was approved by the regional ethics committee. Between 2014 and 2015, 33 patients (median age 51.3 years; range 42.1-77.3 years) who underwent prostate-MRI at 3T scanners at 2 different institutions, acquired with (mpMRI_ERC) and without (mpMRI_PPA) ERC and who received radical prostatectomy, were included in this retrospective study. Two expert readers (R1, R2) attributed a PI-RADS version 2 score for the most suspect (i. e. index) lesion for mpMRI_PPA and mpMRI_ERC. Sensitivity and positive predictive value for detection of index lesions were assessed using 2 × 2 contingency tables. Differences between groups were tested using the McNemar test. Whole-mount histopathology served as reference standard. Results: On a quadrant-basis cumulative sensitivity ranged between 0.61-0.67 and 0.76-0.88 for mpMRI_PPA and mpMRI_ERC protocols, respectively (p > 0.05). Cumulative positive predictive value ranged between 0.80-0.81 and 0.89-0.91 for mpMRI_PPA and mpMRI_ERC protocols, respectively. The differences were not statistically significant for R1 (p = 0.267) or R2 (p = 0.508). Conclusion: Our results suggest that there may be no significant differences for detection of prostate cancer between images acquired with and without an ERC.

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Section: Discussionsupporting

confidence: 90%

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study

Barth¹,

Rupp²,

Cornelius³

et al. 2019

Current Urology

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“…In the subgroup of patients lower-grade PCa, the summed PI-RADS score of T2WI and DWI only resulted in similar good test accuracy. In agreement with mp-MRI after radiation therapy, there were no additional benefits if DCE was added to T2WI and DWI [20]. However, for higher-grade PCa detection, DCE further improved data accuracy.…”

Section: Discussionmentioning

confidence: 54%

MR-sequences for prostate cancer diagnostics: validation based on the PI-RADS scoring system and targeted MR-guided in-bore biopsy

et al. 2014

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“…In another study, Morgan et al [36] also emphasized the added vale of DWI, concluding that ADC measurement is useful for detecting local tumor relapse larger than 0.4 cm 2 within the prostate. In a more recent study, Donati et al [37] concluded that the combination of T2WI and DWI achieves the best overall diagnostic accuracy and the highest inter-reader agreement in the detection of recurrent PCa after RT. In other studies, Arumainayagam et al [38] and Akin et al [39] demonstrated that mp-MRI using T2WI, DCE-MRI, and DWI is an accurate test for detecting radio-recurrent PCa.…”

Section: External Beam Radiotherapymentioning

confidence: 99%

Post-treated prostate cancer: normal findings and signs of local relapse on multiparametric magnetic resonance imaging

et al. 2015

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The use of multiparametric magnetic resonance imaging (mp-MRI) for prostate cancer has increased over recent years, mainly for detection, staging, and active surveillance. However, suspicion of recurrence in the set of biochemical failure is becoming a significant reason for clinicians to request mp-MRI. Radiologists should be able to recognize the normal post-treatment MRI findings. Fibrosis and atrophic remnant seminal vesicles after prostatectomy are often found and must be differentiated from local relapse. Moreover, brachytherapy, external beam radiotherapy, cryosurgery, and hormonal therapy tend to diffusely decrease the signal intensity of the peripheral zone on T2-weighted images (T2WI) due to the loss of water content, consequently mimicking tumor and hemorrhage. The combination of T2WI and functional studies like diffusionweighted imaging and dynamic contrast-enhanced improves the identification of local relapse. Tumor recurrence tends to restrict on diffusion images and avidly enhances after contrast administration either within or outside the gland. The authors provide a pictorial review of the normal findings and the signs of local tumor relapse after radical prostatectomy, external beam radiotherapy, brachytherapy, cryosurgery, and hormonal therapy.

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Multiparametric Prostate MR Imaging with T2-weighted, Diffusion-weighted, and Dynamic Contrast-enhanced Sequences: Are All Pulse Sequences Necessary to Detect Locally Recurrent Prostate Cancer after Radiation Therapy?

Abstract: MP MR imaging has greater accuracy in the detection of recurrent PCa after RT than T2-weighted imaging alone, with no additional benefit if DCE is added to T2-weighted imaging and DW imaging.

Cited by 116 publications

References 37 publications

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study

MR-sequences for prostate cancer diagnostics: validation based on the PI-RADS scoring system and targeted MR-guided in-bore biopsy

Post-treated prostate cancer: normal findings and signs of local relapse on multiparametric magnetic resonance imaging

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