Multiparametric US for Identifying Patients with High-Risk NASH: A                     Derivation and Validation Study

Sugimoto, Katsutoshi; Lee, Dong Hoon; Lee, Jae Young; Yu, Su Jong; Sakamaki, Kentaro; Oshiro, Hisashi; Takahashi, Hiroshi; Kakegawa, Tatsuya; Tomita, Yusuke; Abé, Masakazu; Yoshimasu, Yu; Takeuchi, Hirohito; Choi, Byung Ihn; Itoi, Takao

doi:10.1148/radiol.2021210046

Cited by 28 publications

(19 citation statements)

References 28 publications

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“…Among these, acoustic radiation force (ARF)-based elastographic techniques are widely accepted as screening techniques for liver fibrosis [9,10], mainly because of the lack of requirement for a separate mechanical actuator, similar clinical setup to that of US examinations, and no motion artifact on the probe [9, [11][12][13]. Furthermore, as ARF-induced shear waves are broadband, 2D SWE techniques provide better spatial resolution and favor shear wave dispersion analysis [14,15], which can detect inflammation. Several studies have reported that 2D SWE techniques show high diagnostic performance in detecting significant liver fibrosis or liver cirrhosis and nonalcoholic steatohepatitis [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, as ARF-induced shear waves are broadband, 2D SWE techniques provide better spatial resolution and favor shear wave dispersion analysis [14,15], which can detect inflammation. Several studies have reported that 2D SWE techniques show high diagnostic performance in detecting significant liver fibrosis or liver cirrhosis and nonalcoholic steatohepatitis [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, many ultrasound vendors have developed 2D SWE techniques [8] that may provide advantages over point SWE, including real-time capabilities, large sample volumes, and rapid acquisition time [15,20,21]. Technically, 2D SWE techniques can be classified into two methods for shear wave detection or tracking: 1) plane wave imaging (PWI), which uses a software beamformer that can beamform the whole field-of-view (FOV) with a single pushecho insonification [11,14]; and 2) the multi-beam (MB) technique (parallel tracking A c c e p t e d A r t i c l e methods), which uses a parallel beamforming technique that allows beamforming of multiple imaging lines simultaneously [22,23].…”

Section: Introductionmentioning

confidence: 99%

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Intra-individual comparison of two-dimensional shear wave elastography techniques using plane wave imaging and the multi-beam technique: are they interchangeable in measuring liver fibrosis?

et al. 2023

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Objective: To compare two different two-dimensional (2D) shear wave elastography (SWE) techniques, plane wave imaging (PWI) and multi-beam (MB), from the same vendor, to evaluate liver fibrosis. Materials and Methods:In this prospective study, 42 patients with chronic liver disease who had recently undergone magnetic resonance (MR) elastography (<3 months) were enrolled, and their liver stiffness (LS) values were measured using two different 2D SWE techniques (PWI or MB) from the same vendor. The LS values (kPa) of the two techniques were compared using a Wilcoxon rank-sum test. Inter-technique reproducibility and intra-observer repeatability were assessed using Bland-Altman analysis with 95% limits of agreement (LOA) and coefficients of variation (CVs). The cut-off values of 2D SWE techniques in predicting severe fibrosis (≥F3) were estimated using receiver operating characteristic curve (ROC) analysis, with the LS value on MR elastography serving as the reference standard.Results: Among the 42 patients, there was a technical failure of the PWI technique in four. Therefore, 38 patients underwent both examinations using both techniques. The LS values of PWI and MB techniques showed a moderate agreement (CV, 22.5%) and a 95% LOA of −3.71 to 7.44 kPa. Regarding intra-observer repeatability (CV), the MB technique showed good agreement (8.1%) while PWI technique showed moderate agreement (11.0%).The cut-off values of the PWI and MB techniques for diagnosing ≥F3 were 12.3 kPa and 13.8 kPa, respectively, with the ROC curve areas of 0.89 and 0.95 (sensitivity, 100% and 100%; specificity, 65.6%, and 85.7%).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intra-individual comparison of two-dimensional shear wave elastography techniques using plane wave imaging and the multi-beam technique: are they interchangeable in measuring liver fibrosis?

et al. 2023

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Recently, a new ultrasound (US) elastography method based on the analysis of the shear wave dispersion (SWD) slope has been able to quantitatively measure SW speed related to viscoelasticity and SWD slope related to viscosity ( 17 ). Previous studies have applied this method to assess nonalcoholic fatty liver disease ( 20 , 21 ). Furthermore, studies suggest that SWD slope, as a new noninvasive method, has potential value in evaluating liver disease activity in primary biliary cholangitis ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of shear wave dispersion imaging for viscoelastic assessment of the liver in acute graft-versus-host disease rats

Xiong¹,

Xin²,

Liu³

et al. 2022

Quant Imaging Med Surg

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Background: To investigate the feasibility of using shear wave dispersion (SWD) imaging to evaluate hepatic acute graft-versus-host disease (aGVHD) in a rat model. Methods:To establish an aGVHD model, 30 Wistar rats were subjected to bone marrow transplantation, 10 Fischer 344 rats were used as donors, and 6 Wistar rats were used as the control group. Each week, 6 rats were randomly chosen and divided into groups of 1 week (1 w) to 5 weeks (5 w). For each subgroup, the rats received clinical index assessment and shear wave dispersion (SWD) examination with 2 quantitative values, shear wave (SW) speed and SWD slope. The histological characteristics were then used as the reference standard to divide the rats into the aGVHD group and the no aGVHD (nGVHD) group.Results: In the 2 weeks (2 w) group, only SWD slope [median: 7.26, interquartile range (IQR): 7.04 to 7.31] showed a significant increase in the measured value (P<0.05). The value of the 3 weeks (3 w) group (median: 7.88, IQR: 7.84 to 8.49) significantly increased compared with the 2 w value (P<0.05). Although the value increased gradually from week 3 to week 5, it had no statistical significance (P>0.05). The SW speed [mean ± standard deviation (SD): 1.54±0.11, 95% confidence interval (CI): 1.48 to 1.59] and SWD slope (mean ± SD: 8.29±0.56, 95% CI: 7.99 to 8.59) of the aGVHD group were higher than those of the control group and the nGVHD group (P<0.001). The correlation of SWD slope with pathological grade was the highest (r=0.798, P<0.01), followed by SW speed (r=0.785, P<0.01), and the correlation of clinical index with pathological grade was the lowest (r=0.751, P<0.01). In addition, the area under the receiver operating characteristic (ROC) curve (AUC) value of aGVHD using the SWD slope was 0.844 (95% CI: 0.67 to 0.95, sensitivity: 93.75%, specificity: 78.57%), which was higher than the AUC of both SW speed and clinical index, and the difference was statistically significant compared to the AUC of the clinical index. Conclusions:The SWD slope could show significant abnormalities earlier than SW speed and clinical index and is also more consistent with change in aGVHD severity level. The SWD slope may help in detecting hepatic aGVHD during ultrasound SWD examination.

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Role of multiparametric US in the preoperative assessment of hepatic parenchyma in patients with liver tumors

Wang,

Zhang,

Wang

et al. 2024

Abdom Radiol

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Multiparametric US for Identifying Patients with High-Risk NASH: A Derivation and Validation Study

Cited by 28 publications

References 28 publications

Intra-individual comparison of two-dimensional shear wave elastography techniques using plane wave imaging and the multi-beam technique: are they interchangeable in measuring liver fibrosis?

Intra-individual comparison of two-dimensional shear wave elastography techniques using plane wave imaging and the multi-beam technique: are they interchangeable in measuring liver fibrosis?

Efficacy of shear wave dispersion imaging for viscoelastic assessment of the liver in acute graft-versus-host disease rats

Role of multiparametric US in the preoperative assessment of hepatic parenchyma in patients with liver tumors

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