2021
DOI: 10.1007/s11095-021-03062-4
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Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Sensitivity Analysis

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Cited by 18 publications
(3 citation statements)
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“…Notably, our chip does not simulate poroelastic convective transport of subcutaneously administrated drugs ( 16 ). The time scales associated with significant subQ convection span a few seconds, aligning closely with the injection duration ( 15 , 16 , 66 ). On the other hand, subQ pharmacokinetics are characterized by much longer time scales spanning several days.…”
Section: Discussionmentioning
confidence: 99%
“…Notably, our chip does not simulate poroelastic convective transport of subcutaneously administrated drugs ( 16 ). The time scales associated with significant subQ convection span a few seconds, aligning closely with the injection duration ( 15 , 16 , 66 ). On the other hand, subQ pharmacokinetics are characterized by much longer time scales spanning several days.…”
Section: Discussionmentioning
confidence: 99%
“…The main gap is to be able to predict tissue backpressure with highly viscous solutions or solutions which have non-Newtonian viscous behaviour. For example, this work could benefit from the multiphysics model introduced by Zheng et al [ 63 ] and Hou et al [ 64 ] to gain additional mechanistic insights into fluid flow through tissue as well as the impact of viscosity and mechanical interlocking of hyaluronan. This latter point will greatly benefit from a more mechanistic fluid flow model since the degradation rate of hyaluronan following infusion of formulations comprising rHuPH20 will dynamically alter the resistance to fluid flow.…”
Section: Discussion and Outlookmentioning
confidence: 99%
“…However, these models focus on the material response and fluid pressure change in interstitial tissue, and do not model the changes of fluid pressures in blood vessels and lymphatic vessels or the drug transport induced by the material responses. Drug transport coupled with tissue deformation is also considered in some studies (Han et al., 2021 ; Hou et al., 2021 ; Zheng et al., 2021a ; Leng et al., 2022 ; Rahimi et al., 2022 ). Nevertheless, these studies apply a linear model to describe the lymphatic uptake assuming that the lymphatic fluid pressure is constant, and ignore changes in lymphatic pressure due to tissue deformation and fluid flow.…”
Section: Introductionmentioning
confidence: 99%