Multiple and Familial Eccrine Angiomatous Hamartoma

Rodríguez-Vázquez, María; Calle, Pilar Cortina-de la; Romero-Aguilera, G.; López-Pérez, Rafael

doi:10.1080/00015550510027072

Cited by 14 publications

(32 citation statements)

References 14 publications

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“…Only 7.7% of cases had adult onset. The higher rates of lesions on the extremities (69.2%) and solitary lesions (80.8%) were similar to those in the study by García-Arpa et al [25]. …”

Section: Discussionsupporting

confidence: 79%

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Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Sanusi

Li²,

Sun³

et al. 2015

Dermatology

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Background: Eccrine angiomatous hamartoma (EAH) is a rare benign cutaneous tumor characterized by the proliferation of eccrine glands and capillaries. Objective: The aim of this study was to summarize the clinicopathological characteristics of EAH. Methods: A retrospective chart review was performed on all patients diagnosed with EAH from 1977 to 2012 in the Union Hospital, Wuhan, P.R. China, and the clinicopathological features were compared with the cases reported in the literature. Results: A total of 26 patients with EAH were identified. The male:female ratio was 1.2:1. EAH most commonly presents as a solitary (80.8%) plaque (50.0%) on the lower extremities (61.5%). Most patients presented with hyperhidrosis localizing to the lesion. Although most patients did not have major pain or anatomic deformity, one patient had severe pain as well as difficulty walking and moving, necessitating leg amputation. The histopathological findings showed typical features of EAH. Conclusion: EAH is a rare but characteristically benign skin hamartomatous condition. In rare occasions it can be associated with severe structural and functional impairment.

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“…Only 7.7% of cases had adult onset. The higher rates of lesions on the extremities (69.2%) and solitary lesions (80.8%) were similar to those in the study by García-Arpa et al [25]. …”

Section: Discussionsupporting

confidence: 79%

“…The vascular elements were labeled positively for anti- Ulex europaeus and anti-factor VIII antigens. Immunohistochemical analyses using CEA, S100 and cytokeratins have demonstrated no definite difference between normal eccrine glands and those in EAH [11,14,16,25]. …”

Section: Discussionmentioning

confidence: 99%

Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Sanusi

Li²,

Sun³

et al. 2015

Dermatology

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“…Immunohistochemical analyses have demonstrated no definite difference between normal eccrine glands and those in EAH. 4,6,12 We found a similar pattern with the addition CD31 lined vessels, CEA and KL-1 positive ducts and SMA and KL-1 positive glands. Importantly, the immunohistochemical profiles of EAH and nonlesional skin were comparable on these parameters as well.…”

Section: Discussionsupporting

confidence: 62%

“…2,12,13 We disclosed no anamnestic, clinical or paraclinical clues to the sudden enlargement and increased hyperhidrosis in our patient.…”

Section: Discussionmentioning

confidence: 95%

Large eccrine angiomatous hamartoma: a novel clinical presentation of disease

Nygaard

Dalager

Spaun

et al. 2015

J Dermatol Case Rep

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Background: Eccrine angiomatous hamartoma is a rare benign cutaneous malformation with a diverse clinical appearance, therefore likely to be misdiagnosed and underreported.Main observations: A 44-year-old man presented with a congenital erythematous hyperhidrotic plaque on the left upper back measuring 18 x 25 cm. No pain or tenderness nor hypertrichosis were observed. Histopathology was consistent with the mucinous variant of eccrine angiomatous hamartoma. Intralesional injection of botulinum toxin type A greatly reduced localized sweating, improving patient quality of life. Conclusions:This article describes a novel clinical presentation of eccrine angiomatous hamartoma: large, erythematous, and slightly indurated plaque localized on the upper back. It emphasizes the role of histopathology in the diagnostic process and botulinum toxin as a viable treatment option. (J Dermatol Case Rep. 2015; 9(3): 58-61)

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“…The clinical phenotype of EAH has been reviewed tocently (1)(2)(3). To date, 46 cases of EAH have been reported, excluding the present case.…”

Section: Discussionmentioning

confidence: 81%

Adult-onset Multiple Eccrine Angiomatous Hamartoma in Enlarging Hairy Plaques

Sugimoto¹,

Araki²,

Inoguchi³

et al. 2007

Acta Derm Venereol

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Sir,Eccrine angiomatous hamartoma (EAH) is a rare benign hamartoma of eecrine glands and biood vessels. It most commonly develops before adulthood as a single, slowgrowing lesion on the extremities. We describe here a case of adull-onset EAH with generalized multiple hairy reddish-brown indurated plaques with a rapidly progressive course. As the lesions showed histopathological findings such as an increase in mature eccrine glands and blood vessels, the diagnosis was determined to be EAH. This case was observed carefully because tlie lesion had characteristies not only of a hamartoma but also of a tumour. CASE REPORTA 40-year-old man presented with a 5-year history of multiple enlarging plaques on his trunk and extremities. The first lesion appeared on his right thigh as a reddish-brown plaque. Within one year of onset, new plaques and nodules began to develop on his trunk and other extremities. All ofthe lesions increased in size continuously. Some were associated with occasional stabbing pain, but otherwise they were asymptomatic. Physical examination revealed as many as 1 5 reddishbrown plaques and flat nodules over the patient's chest, abdomen, back, buttock, left axilla, legs, arms, and ieft dorsal hand with or without mild hypcrtrichosis (Fig. 1). Some lesions showed moderate indurations. At a 2-year follow-up visit, all lesions showed considerable enlargement. The 2 indurated plaques on the upper back had grown into a singie fused large plaque of --25x50 cm. Some lesions that initially were only mildly hypertrichotic had even more thickened hair {Fig. 1).Biopsied specimens taken from lesions on the right forearm demonstrated increased well-differentiated sweat glands and partially dilated vascular channels in the deeper dermis (Fig. 2). Two types of blood vessel proliferation were noted: one with thick walls as seen in cavernous haemangioma and the other with thin walls like those of capillary haemangioma ( Fig. 213 and C). Abundant mucin deposition surrounded the proliferating units of eecrine glands and vessels (Fig. 2C). Mild Fig. I. Clinical appearance ofthe reddish-brown plaques on: (A) left dorsal hand; (B) medial sideorilie right forearm; (C) bultock, and; (D) righl upper back. The lesions in (A) and (B) show aggressive cnlargcmeiil iind mort' severe hypcrtrichosis uiler 2 years of observation (A(2y), B(2y)). Ada Derm Venereot 87

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Multiple and Familial Eccrine Angiomatous Hamartoma

Cited by 14 publications

References 14 publications

Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

Large eccrine angiomatous hamartoma: a novel clinical presentation of disease

Adult-onset Multiple Eccrine Angiomatous Hamartoma in Enlarging Hairy Plaques

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