Multiple basal cell carcinomas in a patient of oculocutaneous albinism

Behera, Deepak Kumar; Tripathy, Tapaswini; Kar, Bikash Ranjan

doi:10.4103/2229-5178.202262

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…We have identified 54 cases of skin carcinomas dominated by BCC (57.4%), with some patients having more than one tumor, and some of them having more than one (histologically confirmed) diagnosis. This finding of multiple lesions has already been made in the literature in this population [ 8 , 9 , 17 , 18 ], including 14% (4 cases) of combined BCC and SCC in Brazil [ 8 ], one case of multiple BCC in India [ 17 ] and one case of SCC, Bowen’s disease in Japan [ 18 ]. In our study, there was a predominance of BCC with a BCC/SCC ratio of 1.47.…”

Section: Discussionsupporting

confidence: 65%

Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics

et al. 2021

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Background In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. Methods This is a cross-sectional study of medical records of PWA systematically examined during two mobile skin care clinics in 2019, as part of a programme for the prevention and management of skin cancers in these subjects. Results During the study period, 280 (95.2%) of the 294 PWA consulted, had developed skin lesions. Of the 280 PWA, the pathological reports from the medical records of 33 patients (11.8%; (95%CI = [8.2–16.2]) had concluded to non-melanoma skin cancers. The mean age of these 33 patients was 38.6 ± 15.2 years and the sex-ratio was 1. Their occupations were mainly resellers (21.2%), traders (15.2%) and farmers (12.2%). In the 33 patients, 54 cases of non-melanoma skin cancers were identified, with some patients having more than one tumor, and some of them having more than one (histologically confirmed) diagnosis. These 54 non-melanoma skin cancers were divided into 21 cases of invasive squamous cell carcinomas, 2 cases of Bowen’s disease and 31 cases of basal cell carcinomas. These non-melanoma skin cancers mainly occurred in the head and neck (33 cases; 61.1%), the upper limbs (15 cases; 27, 8%) and the trunk (4 cases; 7.4%). Conclusion The results of this study show a high prevalence of skin cancers among PWAs in Togo in 2019, only non-melanoma skin cancers. In addition, they illustrate the role of ultraviolet rays with regard to the localization of skin cancers and the occupations of patients. Popularization and compliance with photo protection measures, systematic and regular examination of the skin of these PWAs will allow early detection and treatment of these skin cancers.

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Section: Discussionsupporting

confidence: 65%

Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics

et al. 2021

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Identifying and characterizing basal cell carcinomas in persons with albinism

2020

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Background Historically, persons with albinism (PWA) were thought to develop squamous cell carcinoma (SCC) more frequently than basal cell carcinoma (BCC). Recent evidence suggests BCCs in PWA are more common than initially hypothesized. Objective To characterize the presentation of BCC in PWA. Methods Fifty‐four PWA with lesions suspicious for non‐melanoma skin cancer sought care at Tanzanian dermatologic clinics from 2017 to 2019. Demographic and clinical presentation data were recorded. Histologic analysis of each sample was completed. Results The majority of PWA were female (53.7%), with a mean age of 34.6 ± 14.9 years and a mean duration of disease of 0.70 ± 0.73 years. Physician description of histologically proven BCC included ulceration (41.7%), erythema (16.7%), and scale (16.7%). Lesions were most commonly located on the trunk (47.1%) and face (41.2%). Histologic analysis demonstrated 30.2% of lesions were BCC, 26.4% SCC, and 17% Bowen's disease. Limitations Patient population was limited to those visiting clinics, and data were limited by accuracy of the medical record. Conclusions Basal cell carcinoma occurs at a higher rate than SCC in our population, suggesting BCC in PWA is underdiagnosed. It is important to recognize BCC early in PWA to avoid large disease burden and high rates of morbidity and mortality.

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Multiple basal cell carcinomas in a patient of oculocutaneous albinism

Cited by 2 publications

References 6 publications

Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics

Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics

Identifying and characterizing basal cell carcinomas in persons with albinism

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