Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum

Ji, Chenglong; Wu, Huifeng; Zhou, Mo; Zhao, Jianmin

doi:10.1016/j.fsi.2015.03.024

Cited by 26 publications

(8 citation statements)

References 34 publications

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“…Interestingly, decreased succinate and alanine and increased aspartate were found in Cd-treated Dshape larval mussels, which suggested that Cd exposure reduced the anaerobiosis in D-shape larval mussels. In clam Ruditapes philippinarum, however, the anaerobiosis was enhanced by Cd exposure (Ji et al 2015). The contrary findings meant the species-specific effects in anaerobiosis induced by Cd in marine bivalves.…”

Section: Resultsmentioning

confidence: 87%

Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium

et al. 2016

Ecotoxicology

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Cadmium (Cd) is one of the most important metal contaminants in the Bohai Sea. In this work, NMR-based metabolomics was used to investigate the toxicological effects of Cd at an environmentally relevant concentration (50 µg L −1 ) in three different life stages (D-shape larval, juvenile and adult) of mussels Mytilus galloprovincialis. Results indicated that the D-shape larval mussel was the most sensitive life stage to Cd. The significantly different metabolic profiles meant that Cd induced differential toxicological effects in three life stages of mussels. Basically, Cd caused osmotic stress in all the three life stages via different metabolic pathways. Cd exposure reduced the anaerobiosis in D-shape larval mussels and disturbed lipid metabolism in juvenile mussels, respectively. Compared with the D-shape larval and juvenile mussels, the adult mussels reduced energy consumption to deal with Cd stress.

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Section: Resultsmentioning

confidence: 87%

Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium

et al. 2016

Ecotoxicology

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“…It may induce oxidative stress in organisms by producing excessive reactive oxygen species [3]. Additionally, Cd can disturb the energy metabolism in clam Ruditapes philippinarum indicated by the enhanced anaerobic metabolism [4]. Since Cd has become one of the most severe metal contaminants in the Bohai Sea, it is necessary to characterize the biological effects of Cd in marine animals.…”

Section: Introductionmentioning

confidence: 99%

Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages

Peng

et al. 2016

Fish & Shellfish Immunology

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a b s t r a c tCadmium (Cd) has become an important metal contaminant and posed severe risk on the organisms in the coastal environments of the Bohai Sea. Marine mussel Mytilus galloprovincialis is widely distributed along the Bohai coast and consumed as seafood by local residents. Evidences indicate that the early stages of marine organisms are more sensitive to metal contaminants. In this study, we applied twodimensional electrophoresis-based proteomics to characterize the biological effects of Cd (50 mg L À1 ) in the early life stages (D-shape larval and juvenile) of mussels. The different proteomic responses demonstrated the differential responsive mechanisms to Cd exposure in these two early life stages of mussels. In details, results indicated that Cd mainly induced immune and oxidative stresses in both Dshape larval and juvenile mussels via different pathways. In addition, the significant up-regulation of triosephosphate isomerase and metallothionein confirmed the enhanced energy demand and mobilized detoxification mechanism in D-shape larval mussels exposed to Cd. In juvenile mussels, Cd exposure also induced clear apoptosis. Overall, this work suggests that Cd is a potential immune toxicant to mussel M. galloprovincialis at early life stages.

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“…KEGG annotation showed that betaine was related to ABC transporters and the glycine, serine, and threonine metabolism. Ji et al (2015) used betaine as a biomarker of Cd stress in clams.…”

Section: Discussionmentioning

confidence: 99%

“…Metabolomics has been widely used in the study of plants ( Sumner et al, 2003 ; Mwamba et al, 2020 ), animals ( Ji et al, 2015 ; Kim et al, 2016 ; Song et al, 2018 ), microorganisms ( Milreu et al, 2013 ), and ecosystems ( Boroujerdi et al, 2009 ), as well as in elucidating the toxicity mechanisms of pollutants because it maps alterations in metabolites induced by exposure ( Nicholson et al, 1999 ; Sugiura et al, 2005 ). The high applicability of metabolomics is because it qualitatively and quantitatively characterizes the chemical characteristics of low-molecular metabolites (<1,000 Da), which are the final products of cell regulatory pathways in cells, tissues ( Cappello, 2020 ; Sun et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Alterations in the Digestive System of the Mantis Shrimp Oratosquilla oratoria Following Short-Term Exposure to Cadmium

Liu

Han

et al. 2021

Front. Physiol.

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Mantis shrimp Oratosquilla oratoria is an economically critical aquatic species along the coast of China but strongly accumulates marine pollutant cadmium (Cd) in its digestive system. It is necessary to characterize the toxicity of Cd in the digestive system of mantis shrimp. The metabolic process is an essential target of Cd toxicity response. In this work, we used ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-TOF-MS) for untargeted metabolomics to characterize the metabolic changes in the digestive system of O. oratoria, exposed to 0.05 mg/L for 96 h. The aim of this study was to further investigate the effect of O. oratoria on Cd response to toxicity and develop biomarkers. Metabolomics analysis showed the alteration of metabolism in the digestive system of mantis shrimp under Cd stress. A total of 91 metabolites were differentially expressed and their main functions were classified into amino acids, phospholipids, and fatty acid esters. The enrichment results of differential metabolite functional pathways showed that biological processes such as amino acid metabolism, transmembrane transport, energy metabolism, and signal transduction are significantly affected. Based on the above results, the Cd-induced oxidative stress and energy metabolism disorders were characterized by the differential expression of amino acids and ADP in mantis shrimp, while the interference of transmembrane transport and signal transduction was due to the differential expression of phospholipids. Overall, this work initially discussed the toxicological response of Cd stress to O. oratoria from the metabolic level and provided new insights into the mechanism.

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Multiple biomarkers of biological effects induced by cadmium in clam Ruditapes philippinarum

Cited by 26 publications

References 34 publications

Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium

Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium

Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages

Metabolomic Alterations in the Digestive System of the Mantis Shrimp Oratosquilla oratoria Following Short-Term Exposure to Cadmium

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