Multiple black hepatocellular adenomas in a male patient

Bernard, Pierre–Henri; Blanc, J.-F.; Paulusma, Coen C.; Bail, Brigitte Le; Carles, J; Balabaud, Charles; Bioulac‐Sage, Paulette

doi:10.1097/00042737-200012110-00015

Cited by 14 publications

(12 citation statements)

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“…Case 6 is the first, to our knowledge, showing two rare findings: (i) the association of IHCA and H‐HCA in a man; and (ii) a rare form of H‐HCA with less steatosis than usual, rosette formation, and abnormal GS expression in the absence of detectable β‐catenin nuclear staining. Interestingly, the only case of H‐HCA observed in a man in our institution (not linked to MODY3) showed many pathological similarities with this case . Owing to their extreme rarity, the significance of these features is unclear at present.…”

Section: Discussionmentioning

confidence: 77%

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Coexistence of inflammatory hepatocellular adenomas with HNF1α‐inactivated adenomas: is there an association?

et al. 2014

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Section: Discussionmentioning

confidence: 77%

“…Interestingly, the only case of H-HCA observed in a man in our institution (not linked to MODY3) showed many pathological similarities with this case. 19 Owing to their extreme rarity, the significance of these features is unclear at present.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of inflammatory hepatocellular adenomas with HNF1α‐inactivated adenomas: is there an association?

et al. 2014

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“…Iron [74] or other pigments such as lipofuscin granules, Dubin Johnson pigment [7, 8, 16, 84], hematopoiesis, calcifications [85], and inflammatory granulomas [86–88] are occasionally observed in HCA. Iron is located in hepatocytes in the Fanconi anemia.…”

Section: Hca With Rare or Misleading Featuresmentioning

confidence: 99%

Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context

Bioulac‐Sage

Sempoux

Possenti

et al. 2013

International Journal of Hepatology

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In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in many pathological conditions such as glycogenosis, familial adenomatous polyposis, MODY3, after male hormone administration, and in vascular diseases. Obesity is frequent particularly in inflammatory HCA. The background liver is often normal, but steatosis is a frequent finding particularly in inflammatory HCA. The diagnosis of HCA is more difficult when the background liver is fibrotic, notably in vascular diseases. HCA can be solitary, or multiple or in great number (adenomatosis). When nodules are multiple, they are usually of the same subtype. HNF1α-inactivated HCA occur almost exclusively in woman. The most important point of the classification is the identification of β-catenin mutated HCA, a strong argument to identify patients at risk of malignant transformation. Some HCA already present criteria indicating malignant transformation. When the whole nodule is a hepatocellular carcinoma, it is extremely difficult to prove that it is the consequence of a former HCA. It is occasionally difficult to identify HCA remodeled by necrosis or hemorrhage.

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“…4,5 The current patient was a male with no history of steroid use. It is diffi cult to make a diagnosis of hepatocellular adenoma based only on the fi ndings of diagnostic imaging and histological examinations.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] The presence of a Dubin-Johnson-like pigment in these tumors is even more unusual. 4,5 We herein report the diagnostic imaging fi ndings and the pathological features of a case of hepatocellular adenoma with deposition of Dubin-Johnson-like pigment in a patient without any history of either anabolic or androgenic steroid use.…”

Section: Introductionmentioning

confidence: 99%

Pigmented hepatocellular adenoma: Report of a case

et al. 2011

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Hepatocellular adenoma is a rare, benign neoplasm that is related to the use of contraceptives or androgenic-anabolic steroids. A 51-year-old man with no history of steroid use was found to have a liver tumor. Plain computed tomography showed a high-density tumor that was enhanced in the arterial phase, and the enhancement was prolonged in the delayed phase. Magnetic resonance imaging showed that the tumor was hyperintense on in- and opposed-phase T1-weighted gradient recalled echo images and hyperintense on T1-weighted spin echo images. A partial hepatic resection was performed. A histological examination revealed normal hepatocyte-like tumor cells, composed of abundant dark brown granules of Dubin-Johnson-like pigment, which stained positively for Masson-Fontana stain. The tumor was diagnosed to be a very rare hepatocellular adenoma with the deposition of Dubin-Johnson-like pigment.

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Multiple black hepatocellular adenomas in a male patient

Cited by 14 publications

References 0 publications

Coexistence of inflammatory hepatocellular adenomas with HNF1α‐inactivated adenomas: is there an association?

Coexistence of inflammatory hepatocellular adenomas with HNF1α‐inactivated adenomas: is there an association?

Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context

Pigmented hepatocellular adenoma: Report of a case

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