Multiple Correlations Between Cord Blood Leptin Concentration and Indices of Neonatal Growth

Mellati, Ali Awsat; Mazloomzadeh, Saeideh; Anjomshoaa, Afagh; Alipour, Mohsen; Karimi, Fatemeh Zahra; Mazloomi, Sahar; Kazemi, Seyed Ali Naghi

doi:10.1016/j.arcmed.2009.12.001

Cited by 26 publications

(22 citation statements)

References 51 publications

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“…In this study, the mean value of TG in 33% of females and 35% of males was higher than the 95 th percentile of triglyceride level reported in the Nelson textbook of Pediatrics, which indicates a high frequency of cord blood hypertriglyceridemia in our subjects (34). There are other reports of high cord blood hypertriglyceridemia in Iran (16,17,19,37), yet the level of cord blood TG in our study was higher than other reports from Iran (17,33). High triglyceride level may be due to the relatively high frequency of vitamin D deficiency in Iranian newborns (20,21).…”

Section: Discussioncontrasting

confidence: 56%

“…There are evidences of such associations originating at birth (10)(11)(12). There are many reports of hyperlipidemia at young ages (13)(14)(15), in recent years there are some reports of high cord blood triglyceride level from Iran (16)(17)(18)(19). The high triglyceride level may be due to the relatively high frequency of vitamin D deficiency in Iranian newborns (20).…”

Section: Introductionmentioning

confidence: 99%

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Lipid Profile of Cord Blood in Term Newborns

Kazemi

Sadeghzadeh

2014

J Compr Ped

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Background: Hyperlipidemia is an important risk factor for coronary artery disease. Detection of lipid profile in umbilical cord blood of term newborns could identify neonates with a higher risk of coronary artery disease. Objectives: The aim of the present study was to improve the existing information about cord blood lipid profile of Iranian term newborns. Patients and Methods: This cross-sectional study was conducted on healthy term neonates born from healthy mothers between August and October 2009 in Zanjan, Iran. Ten milliliters of cord blood was collected from the placental end of umbilical vein immediately after the cord clamping. Total cholesterol (TC) and triglyceride (TG) were measured by enzymatic GOD-PAP method with Pars Azmoon kits. High-density lipoprotein-cholesterol (HDL-C) was measured after precipitation of Apo lipoproteins with phosphotungstic acid (PTA). Lowdensity lipoprotein-cholesterol (LDL-C) was calculated by Friedewald's formula. Statistical Analysis was performed by the SPSS statistical package version 16.0 for windows. Results: Of the 174 neonates, 97 were female. Vaginal delivery was recorded in 79.8%. There were no significant differences regarding demographic findings between male and female neonates. The mean values of TC, LDL-C, HDL-C and TG were 73.1 ± 26.5, 28.7 ± 11.1, 27.6 ± 10, and 81.4 ± 37.1mg/dL respectively, with no difference between the two sexes. Conclusions: We found a relatively high value of TC and TG in our study. Considering the relationship between high levels of lipids in the neonatal period and coronary artery disease in the adult population, we recommend future cohort studies for this statistical society.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Lipid Profile of Cord Blood in Term Newborns

Kazemi

Sadeghzadeh

2014

J Compr Ped

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“…In this regard, other investigators have reported a positive association between cord blood total adiponectin as well as HMW adiponectin levels (24) and birth weight, BMI, birth weight-to-length ratio, and leptin levels (25,26), even though this was not confirmed by others (27). Some studies have also provided evidence that high concentrations of leptin can be found in the cord serum of full-term newborns, being closely related to birth weight and fat accumulation (28,29). These findings imply that the relationship between leptin and body fat mass may develop early in life.…”

Section: Pregnancy and Intrauterine And Neonatal Developmentmentioning

confidence: 97%

Leptin and adiponectin in the female life course

Lecke

Morsch

Spritzer

2011

Braz J Med Biol Res

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“…Gender has been shown to modulate both leptin and SLR levels with higher leptin and lower SLR levels in females [1,14,15]. There are other reports refuting an effect of gender on leptin levels [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Association of Cord Blood Leptin, Soluble Leptin Receptor, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-1 on Birth Indices in Healthy Full-Term Newborns

Tennekoon

Poopalapillai²,

Karunanayake³

et al. 2014

Horm Res Paediatr

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Background: Leptin and insulin-like growth factor-I (IGF-I) promote fetal growth. Their availability is modulated by soluble leptin receptor (SLR) and insulin-like growth factor-binding proteins (IGFBP). Studies that accounted for SLR levels when investigating the association of leptin, IGF-I and IGFBPs on birth indices are scarce. Methods: Cord blood leptin, SLR, IGF-I, IGFBP-1 and their association with birth indices were studied in term newborns (n = 110; males = 60). Data were compared between males and females using the Mann-Whitney U test/unpaired Student's t test as appropriate. Univariate correlations and multiple regression analyses were performed to identify variables significantly influencing birth indices. Results: Birth indices were comparable between male and female newborns. Females had a significantly lower SLR (p = 0.0142), a higher leptin/Ponderal index (p = 0.033) and a higher free leptin index (leptin/SLR) (p = 0.0081). Leptin and male gender positively and IGFBP-1 negatively influenced birth weight (p = 0.0005, p = 0.02, and p = 0.005, respectively) and head circumference (p = 0.0052, p = 0.0098, and p = 0.0183, respectively) when accounted for other variables. When tested in a different multiple regression model, the free leptin index positively influenced crown-heel length (p = 0.0016) in addition to birth weight (p < 0.0001) and head circumference (p = 0.0016). Conclusions: In healthy full-term pregnancies, cord blood leptin and IGFBP-1 exert independent and opposing effects on fetal growth.

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Multiple Correlations Between Cord Blood Leptin Concentration and Indices of Neonatal Growth

Cited by 26 publications

References 51 publications

Lipid Profile of Cord Blood in Term Newborns

Lipid Profile of Cord Blood in Term Newborns

Leptin and adiponectin in the female life course

Association of Cord Blood Leptin, Soluble Leptin Receptor, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-1 on Birth Indices in Healthy Full-Term Newborns

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