Multiple cutaneous melanomas associated with gastric and brain metastases

Grander, Lara Caroline; Cabral, Fernanda V.; Lisboa, Alice Paixão; Vale, Gabrielle; Barcauí, Carlos Baptista; Maceira, Juan Piñeiro

doi:10.1590/abd1806-4841.20164374

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Table 4 summarizes the findings of included studies regarding malign melanoma. [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121]…”

Section: Malign Melanomamentioning

confidence: 99%

“…On the other hand, GI tract metastasis was observed in more than 60% of melanoma patients by autopsy. 103,110,111,114,121 The most commonly involved sites include the small and large bowels and rectum; however, gastric metastasis is a rare case 110,111,117,119,121 due to the non-specificity of its symptoms, such as epigastric discomfort, nausea, vomiting, weight loss, hematemesis, and melena. 103,107,110,111,114,117,121 The average survival is four to six months.…”

Section: Malign Melanomamentioning

confidence: 99%

“…103,110,111,114,121 The most commonly involved sites include the small and large bowels and rectum; however, gastric metastasis is a rare case 110,111,117,119,121 due to the non-specificity of its symptoms, such as epigastric discomfort, nausea, vomiting, weight loss, hematemesis, and melena. 103,107,110,111,114,117,121 The average survival is four to six months. 103,107,121 Endoscopy is an effective method for detecting melanoma metastases due to pigmentation, which can then be confirmed by histology and immunohistochemistry.…”

Section: Malign Melanomamentioning

confidence: 99%

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Metastasis to the stomach: a systematic review

Ibrahimli,

Aliyev,

Majidli

et al. 2023

F1000Res

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Background: This study reviews the literature on gastric metastases (GM) in terms of diagnosis, treatment, and outcomes. The goal of this study was to provide clinicians with a reliable and beneficial source to understand gastric metastases arising from various primary tumors and to present the growing literature in an easily accessible form. Methods: Articles published in English language from implementation of MEDLINE and Cochrane databases until May 2022 were considered for the systematic review. Articles other than English language, letters to the editor, posters, and clinical images were excluded. Hematogenous and lymphogenic metastases were included whereas direct tumoral invasion and seeding were excluded. Articles and abstracts were analyzed and last selection was done after cross-referencing and by use of defined eligibility criteria. Results: In total 1,521 publications were identified and 170 articles were finally included totaling 186 patients with GM. The median age of patients was 62 years. Gynecologic cancer was the most common cancer type causing GM (67 patients), followed by lung cancer (33 patients), renal cancer (20 patients), and melanoma (19 patients). One of the main treatment methods performed for metastasis was resection surgery (n=62), sometimes combined with chemotherapy (ChT) or immunotherapy. ChT was the other most used treatment method (n=78). Also, immunotherapy was amongst the most preferred treatment options after surgery and ChT (n=10). Conclusions: As 172 case reports were screened in the systematic review from different journals, heterogeneity was inevitable. Some articles missed important information such as complete follow-up or clinical information. Moreover, since all of the included articles were case reports quality assessment could not be performed. Among 172 case reports reviewed, resection surgery was performed the most and was sometimes combined with ChT and immunotherapy. Further research about what type of treatment has the best outcomes for patients with gastric metastases is needed.

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“…Table 4 summarizes the findings of included studies regarding malign melanoma. [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121]…”

Section: Malign Melanomamentioning

confidence: 99%

Section: Malign Melanomamentioning

confidence: 99%

Section: Malign Melanomamentioning

confidence: 99%

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Metastasis to the stomach: a systematic review

Ibrahimli,

Aliyev,

Majidli

et al. 2023

F1000Res

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“…The digestive tract is not a common site of metastasis, but, if diagnosed, the small intestine is most frequently involved. Gastric metastases are found in only 7% of such cases 4,5 . However, among metastases in the gastrointestinal tract, melanoma is the most common tumor, reported in 23% of necropsies.…”

mentioning

confidence: 99%

Gastric metastases of a malignant melanoma

et al. 2019

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Malignant melanoma accounts for around 5% of all malignant skin tumors. It is considered one of the most aggressive neoplasms due to its high metastasizing capacity. The most common sites of metastasis are peri-tumor lymph nodes, lung, brain and liver. The digestive tract is not a common site of metastasis. When involved, the small intestine is the organ most commonly affected. The stomach is a rare site of metastasis, found in only 7% percent of the cases. We report a case of a 72-year-old patient with a history of malignant melanoma who presented with acute epigastric pain. Enterotomography, upper endoscopy and additional biopsies confirmed the diagnosis of gastric metastases.

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