Multiple cutaneous neuromas and macular amyloidosis associated with medullary thyroid carcinoma

Skin Lesions in Hereditary Endocrine Tumor Syndromes

“…Recently, Rothberg et al (26) described an association between primary cutaneous amyloidosis and FMTC attributable to a c804 RET mutation; both c634 and c804 RET mutations can be associated with either MEN 2A or FMTC. Additionally, Baykal et al (33) recently described a patient presenting with earlyonset primary cutaneous amyloidosis and mixed features of both MEN 2A and MEN 2B, who was a carrier of a c768 RET mutation. Although the significance of these findings is debatable, this unusual case at least indicates that an association between c768 RET mutations and primary cutaneous amyloidosis in the context of FMTC or MEN 2A cannot be excluded.…”

Multiple palisaded encapsulated neuromas in a child without other associated abnormalities

“…Some of these occurred in patients with features of MEN while others occurred in the absence of other syndromic features (Table I). [5][6][7][8][9] Histologically, PENs are characterized by a proliferation of delicate spindled cells in the upper dermis distributed in distinct fascicles, which can be separated by clear clefts. The spindled nuclei often have a palisaded appearance.…”

Multiple palisaded encapsulated neuromas in siblings: A case report and review of the published work

“…reported a case of linear pigmented cutaneous neuromas with Marfanoid habitus, corneal nerve hypertrophy and abnormal electromyography in the absence of mucosal neuroma, and suspected a possible association between the linear cutaneous neuromas and MEN 2b syndrome. Baykal et al . reported a 45‐year‐old woman with multiple cutaneous neuromas associated with medullary thyroid carcinoma who had a mutation of RET proto‐oncogene; they first demonstrated the clear clinical association between MEN 2b syndrome and multiple cutaneous neuromas in the absence of mucosal neuroma.…”