Multiple direct and indirect roles of Paf1C in elongation, splicing, and histone post-translational modifications
Alex M. Francette,
Karen M. Arndt
Abstract:Paf1C is a highly conserved protein complex with critical functions during eukaryotic transcription. Previous studies have shown that Paf1C is multi-functional, controlling specific aspects of transcription, ranging from RNAPII processivity to histone modifications. However, it is unclear how specific Paf1C subunits directly impact transcription and coupled processes. We have compared conditional depletion to steady-state deletion for each Paf1C subunit to determine the direct and indirect contributions to gen… Show more
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