Multiple evanescent white dot syndrome following influenza immunization - A multimodal imaging study

Ng, Caleb; Jumper, J. Michael; Cunningham, Emmett T.

doi:10.1016/j.ajoc.2020.100845

Cited by 42 publications

(40 citation statements)

References 17 publications

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“…For example, vaccinations against influenza, yellow fever, hepatitis B, and Neisseria meningitidis have been associated with uveitis, acute idiopathic maculopathy, acute macular neuroretinopathy, Vogt-Koyanagi-Harada disease, and multiple evanescent white dot syndrome. 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine

Fowler

Martinez

Pallares

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose We report the case of a 33-year-old male who presented with unilateral central serous retinopathy three days after the injection of a COVID-19 vaccine. Observations A 33-year-old healthy Hispanic male referred to the ophthalmology service due to blurry vision and metamorphopsia in the right eye without any flashes, floaters, eye redness or pain. The patient reported that 69 hours prior to presentation he received the first dose of the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine. He denied any past ocular history or pertinent medical history. He does not take any medicines and denies stressful factors in his life. The clinical examination and imaging tests were consistent with central serous retinopathy that resolved in three months. Conclusions and importance This is the first report of an ocular complication potentially associated with a COVID-19 vaccination. Our case contributes information of a side effect potentially related to this new vaccine.

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Section: Discussionmentioning

confidence: 99%

Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine

Fowler

Martinez

Pallares

et al. 2021

American Journal of Ophthalmology Case Reports

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“…There are additional arguments to those exposed in the editorial by Lages et al, that are speaking for primary choriocapillaritis in MEWDS [ 71 ], including the implication of the choroid in MEWDS shown in numerous reports that cannot be ignored [ 58 , 74 – 76 ]. Furthermore, diverse vaccinations were shown to trigger both MEWDS [ 77 ] and APMPPE cases [ 78 ]. It is most improbable that a vaccine induced immune reaction would directly target the photoreceptors in one case (MEWDS) and the choriocapillaris in the other (APMPPE).…”

Section: Clinicopathology Of Mewdsmentioning

confidence: 99%

Multiple evanescent white dot syndrome (MEWDS): update on practical appraisal, diagnosis and clinicopathology; a review and an alternative comprehensive perspective

Papasavvas¹,

Mantovani

Tuğal-Tutkun

et al. 2021

J Ophthal Inflamm Infect

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Background Multiple evanescent white dot syndrome (MEWDS) is a rare inflammatory eye condition affecting the outer retina as a consequence of choriocapillaris non perfusion. The pathophysiology of MEWDS will be discussed based clinical appraisal and on multimodal imaging appraisal. Methods Narrative review and perspective opinion. Results Literature review results helped us to put forward (1) the specific symptomatology (decreased/blurred vision, photopsia, subjective scotomas), (2) the ill-asserted character of clinical findings (foveal granularity, white dots in fundoscopy), (3) and the crucial importance of multimodal imaging with the diagnostic triad of ICGA hypofluorescent areas, BL-FAF hyperautofluorescent areas and loss/damage of IS/OS-ellipsoid zone on SD-OCT that characterise the disease and can practically help the clinician to diagnose MEWDS. A comprehensive alternative perspective of the disease was formulated. Conclusions The bulk of evidence that we are presenting in this review, thanks to new performing non-invasive and invasive imaging modalities, is sufficiently compelling to consider MEWDS as a primary choriocapillaritis/inflammatory choriocapillaropathy. Multimodal imaging allows the clinician to diagnose MEWDS with a high level of certainty and ensures a precise follow-up.

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“…MEWDS has been reported following influenza vaccination. 24 Patients usually have symptoms of unilateral blurred vision, photopsia, scotomas and purple hue of the vision. Spontaneous recovery would occur in a range of several weeks.…”

Section: Discussionmentioning

confidence: 99%

Transient visual field loss after COVID-19 vaccination: Experienced by ophthalmologist, case report

Jumroendararasame

Panyakorn

Othong

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose The first reported case of bilateral transient visual field defect, experienced by an ophthalmologist, which developed shortly after COVID-19 vaccination (CoronaVac, Sinovac Biotech Ltd., Beijing, China) and confirmed by computerized automated perimetry. Observation The patient is a 42-year-old Thai ophthalmologist. He developed blurred vision within an hour after the second dose of COVID-19 vaccination. We described his self-observed of sequential symptoms, chronologic events, and management steps. The visual field of left congruous hemianopia with respect to vertical midline was detected with computerized automated perimetry. The possible mechanism could be related to an acute vasospasm of the artery in the postchiasmatic visual pathway, triggered by COVID-19 vaccine, Corona Vac. Conclusion and importance With increasing use of the COVID-19 vaccine in the near future, it would be prudent for medical staff and ophthalmologists to be considered and aware of this associated condition.

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Multiple evanescent white dot syndrome following influenza immunization - A multimodal imaging study

Cited by 42 publications

References 17 publications

Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine

Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine

Multiple evanescent white dot syndrome (MEWDS): update on practical appraisal, diagnosis and clinicopathology; a review and an alternative comprehensive perspective

Transient visual field loss after COVID-19 vaccination: Experienced by ophthalmologist, case report

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