Multiple food allergy - unexpected culprits

Abstract

Food allergy has an estimated prevalence of 6%–8% in children. Meat allergy and multiple food allergy due to sensitization to cross-reactive components in infancy is, however, less frequent. A 5-year-old girl was referred to our department with a multiple food allergy history. She had severe immediate worsening of her atopic dermatitis with hen's egg (6 months) and cow's milk introduction (7 months). At the age of 9 months, she presented with recurrent and reproducible atopic dermatitis' worsening and lip edema with the introduction of different meats (chicken, turkey, cow, pork, and rabbit), having the same complaints with fish at 12 months (salmon and hake). At her first appointment she was avoiding hen's egg, cow's milk, meat, and fish (except fresh tuna, codfish, and pollock). We performed skin prick tests (commercial extract and prick-to-prick with whole food) and specific IgE, which revealed sensitization to hen's egg, raw meat (cow, pork, chicken, turkey, duck, lamb, goat, and rabbit; negative for cooked meat), codfish and cow's milk (mild). ISAC was performed, revealing sensitization to 3 cross-reactive components (serum albumins Bosd6, Canf3, and Feld2) and specific food components of chicken's egg/meat (Gald1, 2, 3, and 5), cod (Gadc1), hazelnut (Cora9), and kiwi (Actd1). We present a rare case of multiple food allergy in infancy, where sensitization to cross-reactive components was responsible for most of the children complaints. The detection of serum albumins' involvement was especially important, because it can possibly mean tolerance to these foods in well-cooked forms, substantially improving patient and family's quality of life.

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

“…The grocery store or the surrounding environment might be the source of these allergies [25]. In this study, 84 % were attributable to tuna, mackerel, and codfish allergies as well as in previous studies [26,27], seafood and animals are substantial sources of allergens for dogs. Interestingly, crab/shrimp is unlikely to cause allergies (Figure 5).…”

“…The greatest allergy levels were found in corn (28.7%) and wheat (25.0%), with peas revealing a 9.3 % allergen level (Figure 6b). Several studies [25,26] have found a significant incidence of sensitization to wheat and maize. Sensitization to meat was high in our research and numerous previously published findings (duck 24.4% and lamb 24.1%) and low in turkey (3.8%) [23,33].…”

Reações Adversas a Alimentos E Aceitabilidade Do Cardápio Escolar Por Crianças Assistidas Pelo Programa Nacional De Alimentação Escolar– Pnae

“…Nossos resultados diferem da literatura, o qual informa que a alergia alimentar múltipla devido à sensibilização a componentes reativos na infância é menos frequente (ORNELAS et al, 2018). Uma justificativa é que determinar as estimativas da prevalência de pessoas alérgicas a vários alimentos, tende a ser dificultada porque as pessoas alérgicas a um alimento podem evitar alimentos adicionais ou podem relutar em introduzir alimentos conhecidos por alérgenos comuns (WANG, 2010).…”

In this July

“…Chitta et al [ 7 ] presents an article on cashew nut allergy in Singaporean children. Readers will find a rare case of multiple food allergy in infancy, where sensitization to cross-reactive components, detected by skin prick test, serum allergen specific IgE, and Immune Solid-phase Allergen Chip, was responsible for most of the children's complaints [ 8 ]. Kwak et al [ 9 ] presents a very interesting case which showed enhanced IgE responses after a tick bite from a novel Australian tick, Ixodes australiensis in a known red meat allergy patient.…”