2013
DOI: 10.1016/j.tig.2013.06.003
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Multiple functions of the noncanonical Wnt pathway

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Cited by 132 publications
(116 citation statements)
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“…Similar observations could be achieved when the Ishikawa cells were transfected with a dominant negative Rac1 (N17Rac1) 26 (Figure 5f). Because Rac1 is a known target of Wnt5a signaling 35,36 that has been shown to be essential for cell polarity induction and epithelial function in various organs including the uterus, 9,11,37 we also analyzed the consequence of Rac1 deficiency on uterine Wnt5a expression. As shown in Figure 5g, Wnt5a was comparably expressed in both Rac1 f/f and Rac1 d/d luminal epithelia.…”
Section: Resultsmentioning
confidence: 99%
“…Similar observations could be achieved when the Ishikawa cells were transfected with a dominant negative Rac1 (N17Rac1) 26 (Figure 5f). Because Rac1 is a known target of Wnt5a signaling 35,36 that has been shown to be essential for cell polarity induction and epithelial function in various organs including the uterus, 9,11,37 we also analyzed the consequence of Rac1 deficiency on uterine Wnt5a expression. As shown in Figure 5g, Wnt5a was comparably expressed in both Rac1 f/f and Rac1 d/d luminal epithelia.…”
Section: Resultsmentioning
confidence: 99%
“…2) regulate DVL and other intracellular proteins to activate the Planar Cell Polarity (PCP) pathway, the Wnt-Calcium (Ca 2+ ) pathway and other -catenin/TCF-independent events [18]. In the Wnt-PCP pathway, FZD receptors activate a signaling cascade that involves the small GTPases Rho and Rac and c-Jun N-terminal kinase (JNK), leading to changes in the cytoskeleton and activation of Activator Protein-1 (AP-1) family transcription factors [19]. Noncanonical Wnt stimuli induce association of DVL associated activator of 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 morphogenesis (DAAM) proteins with FZD, DVL and GTP-bound Rho, which is then able to activate Rho-associated, coiled-coil containing protein kinase (ROCK) and even JNK.…”
Section: Noncanonical Wnt Signalingmentioning
confidence: 99%
“…Although JNK is generally associated with phosphorylation and activation of c-Jun, it phosphorylates many other proteins, including activating transcription factor 2 (ATF2) and cyclic AMP response element-binding protein (CREB), which heterodimerize with c-Jun and other AP-1 family members to alter gene expression [20]. This pathway regulates cell polarity in several morphogenetic processes in vertebrates, including gastrulation, neural tube closure and orientation of stereocilia in the inner ear [19]. Calcineurin, CNA; calmodulin kinase II, CAMKII; phospholipase C, PLC; adenylate cyclase, AC; mitogen-activated protein kinase kinase, MKK.…”
Section: Noncanonical Wnt Signalingmentioning
confidence: 99%
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“…These mitotic spindle orientations are induced by cell signaling, from blastomeres derived from the posterior cell at the two‐cell stage embryo − termed P1 −, that triggers actin cytoskeletal reorganizations in the target cells. In C. elegans , these rearrangements are controlled by a polarized Wnt signaling 17 and are part of the process that diversify the fate of the daughter cells after division. Upon local activation of the MOM‐5/Frizzled receptor by a Wnt ligand, at the cellular membrane, the signal is transduced through a signaling cascade until it reaches β‐catenin.…”
Section: Rac/rho Small Gtpases Mediate Spindle Orientation and Cell Dmentioning
confidence: 99%