Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC Highly Correlated with Early Relapse of Breast Cancer Patients in Taiwan

Huang, Ming-Yii; Wang, Yihui; Chen, Fang‐Ming; Lee, Su-Chen; Fang, Wei-Yu; Cheng, Tian−Lu; Hou, Ming‐Feng; Wang, Jaw‐Yuan; Lin, Shiu‐Ru

doi:10.1245/s10434-007-9719-7

Cited by 26 publications

(13 citation statements)

References 22 publications

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“…This finding is similar to the Yogyakarta, Indonesian, 10 Khazakstan, 16 Chinese, 7 Taiwanese, 17 Brazilian, 18 and Italian. 19 But in Malay subjects from our http://mji.ui.ac.id data showed a significant deviated from HardyWeinberg equilibrium.…”

Section: Discussionsupporting

confidence: 83%

The influence of glutathion S-transferase P-1 polymorphism A313G rs1695 on the susceptibility to cyclophosphamide hematologic toxicity in Indonesian patients

2016

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Section: Discussionsupporting

confidence: 83%

The influence of glutathion S-transferase P-1 polymorphism A313G rs1695 on the susceptibility to cyclophosphamide hematologic toxicity in Indonesian patients

2016

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“…It means the study group could be heterogeneous thus may be different from other Persian population in Iran. It should be noted despite of different frequencies in present study from other Iranian ethnic groups which was reported by Rafiee in 2010 [19] there were no statistically significant differences (Iranian Georgian, χ 2 = 1.66, df = 1, p = 0.197 and Iranian Persian, χ 2 = 3.34, df = 1, p = 0.068).…”

Section: Discussioncontrasting

confidence: 52%

“…In our study the prevalence of GSTT1*0 was 25.5% .This result was slightly higher than Turkish, Mexican-Americans and Caucasians but lower than Chinese, Korean and Japanese ( Table 3). The reported frequency for other Iranian groups also presented significant differences between Iranian populations [19]. Iran is a big country with an estimated 70.5 million people that they are ethnically diverse.…”

Section: Discussionmentioning

confidence: 91%

“…Germans [17] and Caucasians [22] and New England [23] have shown less frequency (12-18%) and the prevalence was low among Mexican-American [24]. However, some gradient and intra ethnic differences are reported as well, such as Shanghai [21], Turkey [21], Korea [25][26][27] and Iran [19]. The chi-squared and p-values have been shown in Table 3.…”

Section: Discussionmentioning

confidence: 99%

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Frequency of GSTT1*0 genotype as a non-conjugator phenotype in a group of healthy Iranian people

Aghajany-Nasab¹,

Samiee²,

Panjehpour³

et al. 2011

JBiSE

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Glutathione S-transferases (GSTs) are dimeric mainly cytosolic enzymes involved in detoxification of many exogenous and endogenous disease-causing electrophilic substrates. GSTs also have critical role in phase II biotransformation of a number of drugs, xenobiotics and industrial chemicals and protect cellular macromolecules. The evidences supported that human GSTT1 contributes in the deactivation of reactive oxygen species which more likely to be effective in inflammatory diseases, ageing and some non-cancer diseases also different types of cancers. The GSTT1 is genetically deleted in a high percentage of the different ethnic groups. Although this gene is highly conserved during evolution, it is indeed surprising that the GSTT1 deleted gene could be found in high incidence of human population. Conjugator and non-conjugator phenotypes are coincident with this deletion (GSTT1*1 and GSTT1*0 genotype).The consequences of this deletion could be involved in some diseases outcome, toxicology and drug resistances. In this study the Real-time PCR assay and a set of hybridization probes was used as a one-step and accurate method to estimate the frequency of GSTT1*0 genotype as a non-functional phenotype in 90 healthy individuals from the province of Isfahan in Iran. GSTT1 genotypes were identified in DNA samples using fluorogenic Real-Time PCR (LightCycler) followed by online melting curve analysis. The incidence of GSTT1*1(wild type) and GSTT1*0(Null type) were 74.5% and 25.5% respectively. No differences in genotypes frequencies were perceived in samples stratified by age and gender P> 0.05. The results were compared with other ethnic groups to get more insight into the frequency differences of defected carcinogens metabolizer gene due to deletion polymorphism of GSTT1. It has been indicated the incidence of GSTT1*0 in this group of Iran showed significant differences with East Asian and some European and American countries P< 0.05.The prevalence of GSTT1 null genotype in the study group from Isfahan province of Iran was slightly higher in comparison with other Iranian ethnic group (Iranian Georgian 15.7%), but this difference was not significant (χ2=1.66, P=0.197). Further experimental investigations are needed to inquiry the clinical implications of GSTT1 genetic polymorphism with consider to significant variability among different ethnicities

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“…Of those, 39 examined 1-3 polymorphisms 13,14,16,19,20,23,24,26-28,31,36,37,39-41,45,46,48,50,53,56,60-62,64,65,68,69,72-74,76-79,81,89,91 and 40 more than 3 polymorphisms 15,17,18,21,22,25,29,30,32-35,38,42-44,47,49,51,52,54,55,57-59,63,66,67,70,71,75,80,82-88,90. Fifty four studies examined the GSTM1 polymorphism 13,14,16,17,19-27,30-33,35,37,38,43-46,48,49,51-63,65,68,69,70,72-75,77,78,82,83,85-87, 57 the GSTP1 Ile105Val polymorphism 13-16,18,21,22,…”

Section: Resultsmentioning

confidence: 99%

Translational Medicine and Reliability of Single-Nucleotide Polymorphism Studies: Can We Believe in SNP Reports or Not?

Valachis¹,

Mauri²,

Neophytou³

et al. 2011

Int. J. Med. Sci.

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Background: The number of genetic association studies is increasing exponentially. Nonetheless, genetic association reports are prone to potential biases which may influence the reported outcome.Aim: We hypothesized that positive outcome for a determined polymorphism might be over-reported across genetic association studies analysing a small number of polymorphisms, when compared to studies analysing the same polymorphism together with a high number of other polymorphisms.Methods: We systematically reviewed published reports on the association of glutathione s-transferase (GST) single-nucleotide polymorphisms (SNPs) and cancer outcome.Result: We identified 79 eligible trials. Most of the studies examined the GSTM1, theGSTP1 Ile105Val mutation, and GSTT1polymorphisms (n = 54, 57 and 46, respectively). Studies analysing one to three polymorphisms (n = 39) were significantly more likely to present positive outcomes, compared to studies examining more than 3 polymorphisms (n=40) p = 0.004; this was particularly evident for studies analysing the GSTM1polymorphism (p =0.001). We found no significant associations between journal impact factor, number of citations, and probability of publishing positive studies or studies with 1-3 polymorphisms examined.Conclusions: We propose a new subtype of publication bias in genetic association studies. Positive results for genetic association studies analysing a small number of polymorphisms (n = 1-3) should be evaluated extremely cautiously, because a very large number of such studies are inconclusive and statistically under-powered. Indeed, publication of misleading reports may affect harmfully medical decision-making and use of resources, both in clinical and pharmacological development setting.

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Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC Highly Correlated with Early Relapse of Breast Cancer Patients in Taiwan

Abstract: The results of the present study highly suggest that GSTP1, MDR1, and MTHFR genotypes could be prognostic factors for Taiwanese patients with breast cancer.

Cited by 26 publications

References 22 publications

The influence of glutathion S-transferase P-1 polymorphism A313G rs1695 on the susceptibility to cyclophosphamide hematologic toxicity in Indonesian patients

The influence of glutathion S-transferase P-1 polymorphism A313G rs1695 on the susceptibility to cyclophosphamide hematologic toxicity in Indonesian patients

Frequency of GSTT1*0 genotype as a non-conjugator phenotype in a group of healthy Iranian people

Translational Medicine and Reliability of Single-Nucleotide Polymorphism Studies: Can We Believe in SNP Reports or Not?

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