Multiple genetic variants are associated with colorectal cancer risk in the Han Chinese population

Wang, Nan; Wang, Li; Yang, Hua; Zhang, Hui Qun; Lan, Bing; He, Xue; Jin, Tian; Kang, Long Li; Chen, Chao

doi:10.1097/cej.0000000000000012

Cited by 22 publications

(19 citation statements)

References 19 publications

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“…Of them, two studies written in Chinese were excluded because of the overlap of study subjects [22, 32]. Moreover, one investigation was excluded for only focused on gastric survival not case-control study [51], three publications were excluded due to lack of genotyping data [52-54], one was not focused on cancer [55], and another two that did not pertain to either of these two polymorphism were also excluded [56, 57]. Eventually, 32 publications were included in the final meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Dai

Hua

et al. 2015

Genes Cancer

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PSCA gene plays an important role in cell adhesion, proliferation and survival.Increasing studies have focused on the association of PSCA gene rs2294008 C>T and rs2976392 G>A with cancer risk. However, the conclusions were inconsistent. Therefore, we performed a meta-analysis to elucidate whether there is a true association, or artifact. We systematically searched eligible studies from MEDLINE, EMBASE and CBM database. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association. The final analysis included 32 studies consisting of 30028 cases and 38765 controls for the rs2294008 C>T polymorphism, and 14 studies with 8190 cases and 7176 controls for the rs2976392 G>A polymorphism. Consequently, the PSCA rs2294008 C>T polymorphism was significantly associated with increased overall cancer risk. Further stratifications indicated the increased risk was more pronounced for gastric (diffused type and non-gastric cardia adenocarcinoma) and bladder cancer. A similar association was observed for the rs2976392 G>A polymorphism. This meta-analysis demonstrated that both of the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms are associated with increased cancer risk, especially for gastric cancer and bladder cancer. Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

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Section: Resultsmentioning

confidence: 99%

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Dai

Hua

et al. 2015

Genes Cancer

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“…The single nucleotide polymorphism (SNP) is the most common form of human genetic variations and are significantly associated with many cancers risk (Geng et al, ; Hu et al, ; Tian et al, ). Recently, an increasing number of evidence suggests that genetic susceptibility plays an important role in the occurrence of colorectal cancer (Duan et al, ; Su et al, ; Wang et al, ; Zhang, Li, Du, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population

Chen

Bai

Yue-min

et al. 2019

Molec Gen & Gen Med

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Background Colorectal cancer is the third most common cancer worldwide. Recently, an increasing number of evidences suggest that genetic susceptibility plays an important role in the occurrence of colorectal cancer. This study aimed to better understand the influence of MIR17HG polymorphisms on colorectal cancer susceptibility in the Chinese Han population. Methods We recruited 514 patients with colorectal cancer and 510 healthy controls to investigate the association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population. Genotyping was performed with the Agena MassARRAY platform. We used the χ2 test to compare the distributions of single nucleotide polymorphisms (SNPs) allele and genotypes frequencies between cases and controls. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate the association under genetic models. Linkage disequilibrium between the five SNPs was assessed using the Haploview software. Results Overall analysis found that rs7336610 and rs1428 and haplotype CTAGA were significantly associated with increased risk of colorectal cancer. However, we found rs7318578 was associated with a decreased risk of colorectal cancer in the dominant model. Stratification analysis showed that rs7336610, rs7318578, and rs1428 were also associated with rectal cancer risk. Gender stratification analysis found that rs7336610, rs7318578, rs17735387, and rs1428 were significantly associated with colorectal cancer risk in males. Conclusion In conclusion, this study indicated that the polymorphisms of MIR17HG were associated with colorectal cancer risk. Therefore, our findings may provide new insights into the development of colorectal cancer. Further association and functional studies are of great importance to confirm these results and to define the potential biological mechanism of colorectal cancer.

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“…Colorectal cancer (CRC) ranks among the three most common cancers in terms of both cancer incidence and cancer-related deaths worldwide (1)(2)(3)(4) . CRC is the cancer of the colon and the rectum and approximately two thirds are located in the colon.…”

Section: Introductionmentioning

confidence: 99%

Association of Promoter Region Polymorphisms of Interleukin-10 Gene With Susceptibility to Colorectal Cancer: A Systematic Review and Meta-Analysis

Mirjalili

Moghimi

Aghili

et al. 2018

Arq. Gastroenterol.

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Background -Several epidemiological studies have investigated the association of promoter region polymorphisms of Interleukin-10 (IL-10) gene with colorectal cancer (CRC), while the conclusion is still conflicting and inconclusive. Objective -We conducted this meta-analysis to evaluate the association of promoter region polymorphisms of IL-10 with CRC. Methods -Eligible articles were identified by a search of several bibliographic databases for the period up to March 15, 2018. The strength of the association was measured by odd ratios with 95% confidence intervals. Results -A total of 28 case-control studies with 5,647 CRC cases and 6,908 controls were selected, including 14 studies for IL-10 -1082A>G (rs1800896) polymorphism (2,702 cases and 3,649 controls), eleven studies for -592C>A (rs1800872) polymorphism (3,259 cases and 4,992 controls), and three studies for -819T>C (rs1800871) polymorphism (477 cases and 544 controls). By pooling all eligible studies, we found that the IL-10 -1082A>G and -592C>A polymorphisms were not associated with increased CRC risk in overall population. However, there was significant associations between the IL-10 -819T>C polymorphism and CRC susceptibility under the allele model (A vs G: OR=1.278, 95% CI 1.043-1.566, P=0.018) and the recessive model (AA vs AG+GG: OR=1.709, 95% CI 1.026-2.845, P=0.039). Conclusion -In this meta-analysis we found that IL-10 -819T>C polymorphism was associated with significantly increased risk of CRC; while the IL-10 -1082A>G and -592C>A polymorphisms were not associated with CRC risk. The IL-10 -819T>C polymorphism may be important as suspected predictive factor of CRC occurrence. HEADINGS -Interleukin-10. Colorectal neoplasms. Genetic polymorphism. Meta-analysis.

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Multiple genetic variants are associated with colorectal cancer risk in the Han Chinese population

Cited by 22 publications

References 19 publications

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Association between polymorphisms of MIR17HG and risk of colorectal cancer in the Chinese Han population

Association of Promoter Region Polymorphisms of Interleukin-10 Gene With Susceptibility to Colorectal Cancer: A Systematic Review and Meta-Analysis

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