Multiple “halo nevi” occurring during pembrolizumab treatment for metastatic melanoma

Eruptive halo nevi: A new COVID‐19 vaccine‐related cutaneous adverse event or a paraneoplastic phenomenon?

“… 1 Indeed, the eruption of multiple Sutton nevi in adults has been reported in the literature associated with neoplasms, immunotherapy, and Turner syndrome. 2 , 3 In this study, we describe a patient who presented to our facility complaining of the sudden appearance of multiple Halo nevi on the trunk within a few months. We discussed a possible paraneoplastic etiology or possible association with the anti‐severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2) vaccination.…”

“…1 Indeed, the eruption of multiple Sutton nevi in adults has been reported in the literature associated with neoplasms, immunotherapy, and Turner syndrome. 2,3 In this study, we describe a patient who presented to our facility complaining of the sudden appearance of multiple Halo nevi on the trunk within a few months.…”

The delicate relation between melanocytes and skin immunity: A game of hide and seek

“…Halo naevi can occur before the development of vitiligo and are more common in early‐onset vitiligo (Mahajan et al, 2021). Halo naevi have also been reported after immunotherapy including ipilimumab (anti‐CTLA‐4), nivolumab, pembrolizumab, tocilizumab, IFN‐β‐1a, and alemtuzumab (anti‐CD52) (Kuet & Goodfield, 2014; Lolli et al, 2018; Nicolétis‐Lombart et al, 2019; Plaquevent et al, 2019; Vera‐Iglesias et al, 2012). The development of halo naevi with the IL‐6R antagonist tocilizumab is surprising given the increased levels of IL‐6 in patients with vitiligo.…”

Extensive “halo naevi” phenomenon and regression of melanin during nivolumab treatment in metastatic melanoma: A predictor of a better outcome?

“…In both cases, complete remission of metastatic melanoma was obtained within 24 and 6 months, respectively. 3,4 To the best of our knowledge, we present the first case of extensive Sutton phenomenon during treatment with nivolumab for metastatic melanoma. Notably, this process was associated in our patient with complete regression of the melanin in some naevi.…”