Multiple In vitro biological effects of phenolic compounds from Morus alba root bark

Čulenová, Marie; Sychrová, Alice; Hassan, Sherif T. S.; Berchová‐Bímová, Kateřina; Svobodová, Petra; Helclová, Alexandra; Michnová, Hana; Hošek, Jan; Vasilev, Hristo; Suchý, Pavel; Kuzmínová, Gabriela; Švajdlenka, Emil; Gajdziok, Jan; Čížek, Alois; Suchý, Václav; Šmejkal, Karel

doi:10.1016/j.jep.2019.112296

Cited by 41 publications

(42 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anticancer mechanisms of morusin in the aforementioned cancer types involved apoptosis induction, inhibition of nuclear factor kappa B (NF-κB) activity (Lee et al 2008 ), and the inactivation of signal transducer and activator of transcription 3 (STAT3) signaling (Lim et al 2015 ). Morusin also showed anti-bacterial activity against Enterococcus faecalis greater than the standard antibiotics ampicillin and ciprofloxacin (Čulenová et al 2020 ).…”

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

View full text Add to dashboard Cite

Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09773-1.

show abstract

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Kuwanon T (23) has also shown promising antibacterial activity against several Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis. The MIC values of compound 23 ranged from 4-8 µg/mL which exceeded the activity of standard antibiotics ampicillin and ciprofloxacin [34]. Another promising phenolic compound against HSV-1 is galangin (11), with IC 50 2.5 µM and SI 400.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past few decades, structural and mechanistic enzymology played a central role in virology research, where a wide range of enzymes that play a vital role in viral replication, viral transcription or have an impact on the pathogenesis of infection have become imperative drug targets for therapeutic intervention [117,118]. Recently,Čulenová et al [34] have isolated phenolic compounds from Morus alba root bark, kuwanon C (22), kuwanon T (23), kuwanon U (24) and ethyl 2,4-dihydroxybenzoate (37) with clear inhibitory action against HSV-1, with IC 50 values ranging from 0.64 to 1.93 µ/mL, while kuwanon E (25) and mulberrofuran B (52) inhibited effectively the replication of HSV-2, with EC 50 values of 0.93 and 1.61 µg/mL, respectively. Molecular docking analysis outcomes proved the effects of the active compounds by targeting the HSV-1 DNA polymerase and HSV-2 protease (proposed as competitive inhibitors), which are crucial enzymes that display an important role in the HSV replication cycle.…”

Section: Natural Products Targeting Enzymes Implicated In Hsv Replicamentioning

confidence: 99%

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Treml

Gazdová

Šmejkal

et al. 2020

Viruses

Self Cite

View full text Add to dashboard Cite

Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.

show abstract

“…Morus alba L. known as white mulberry, was originally used in traditional Chinese medicine for treating bacterial infection, inflammation, and viral and other various diseases [83]. After purification of the root bark of the mulberry tree, the flavonoids kuwanon C (15), T ( 16), E (17), and U (18) were isolated.…”

Section: Flavonoids With Potential Anti-herpetic Activitiesmentioning

confidence: 99%

Natural Products and Their Derivatives against Human Herpesvirus Infection

et al. 2021

View full text Add to dashboard Cite

Herpesviruses establish long-term latent infection for the life of the host and are known to cause numerous diseases. The prevalence of viral infection is significantly increased and causes a worldwide challenge in terms of health issues due to drug resistance. Prolonged treatment with conventional antiviral drugs is more likely to develop drug-resistant strains due to mutations of thymidine nucleoside kinase or DNA polymerase. Hence, the development of alternative treatments is clearly required. Natural products and their derivatives have played a significant role in treating herpesvirus infection rather than nucleoside analogs in drug-resistant strains with minimal undesirable effects and different mechanisms of action. Numerous plants, animals, fungi, and bacteria-derived compounds have been proved to be efficient and safe for treating human herpesvirus infection. This review covers the natural antiherpetic agents with the chemical structural class of alkaloids, flavonoids, terpenoids, polyphenols, anthraquinones, anthracyclines, and miscellaneous compounds, and their antiviral mechanisms have been summarized. This review would be helpful to get a better grasp of anti-herpesvirus activity of natural products and their derivatives, and to evaluate the feasibility of natural compounds as an alternative therapy against herpesvirus infections in humans.

show abstract

Multiple In vitro biological effects of phenolic compounds from Morus alba root bark

Cited by 41 publications

References 59 publications

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

Natural Products and Their Derivatives against Human Herpesvirus Infection

Contact Info

Product

Resources

About