Multiple insecticide resistance in Aedes aegypti (Diptera: Culicidae) populations compromises the effectiveness of dengue vector control in French Guiana

Abstract

In French Guiana, pyrethroids and organophosphates have been used for many years against Aedes aegypti. We aimed to establish both the resistance level of Ae. aegypti and the ultra low volume spray efficacy to provide mosquito control services with practical information to implement vector control and resistance management. Resistance to deltamethrin and fenitrothion was observed. In addition, the profound loss of efficacy of AquaK'othrine® and the moderate loss of efficacy of Paluthion® 500 were recorded. Fenitrothion remained the most effective candidate for spatial application in French Guiana until its removal in December 2010. Further investigation of the mechanism of resistance to deltamethrin demonstrated the involvement of mixed-function oxidases and, to a lesser extent, of carboxylesterases. However, these observations alone cannot explain the level of insecticide resistance we observed during tube and cage tests

Multiple Resistances and Complex Mechanisms of Anopheles sinensis Mosquito: A Major Obstacle to Mosquito-Borne Diseases Control and Elimination in China

“…quinquefasciatus [67], [68] in Asia, and Ae. Aegypti in South America [69]. Multiple insecticide resistance impedes the current front-line vector-borne disease control programs, which are primarily based on the use of pyrethroids.…”

Evaluación de la susceptibilidad a insecticidas en poblaciones de Aedes aegypti (Diptera: Culicidae) del departamento de Caldas, Colombia, en los años 2007 y 2011

“…aegypti a la deltametrina (10,21,24) y al fenitrotión (10,11,21). En otros países de la región, como la Guyana Francesa (25), México (26) y Perú (27), así como en el occidente venezolano (23), también se ha reportado resistencia a la deltametrina, y solo en Cuba y Panamá (19,22,28), se ha encontrado resistencia entre moderada y alta al metil-pirimifós.…”

Self-Limiting OX513A Aedes aegypti Demonstrate Full Susceptibility to Currently Used Insecticidal Chemistries as Compared to Indian Wild-Type Aedes aegypti

“…Although specific resistance mechanisms against DDT in insects have not always been fully characterized, increased metabolism of DDT by the glutathione S-transferase (GST) enzyme family and mutations in kdr genes of voltage-gated sodium channels have both been associated with DDT resistance development. Both DDT and pyrethroids affect the nervous system by modifying the gating kinetics of voltage-sensitive sodium channels, and mutations in sodium channels can cause binding failures with DDT and pyrethroids, underlying reports of cross-resistance between DDT and pyrethroids [20][21][22][23][24][25]. In this study, the lack of crossresistance to pyrethroids has implicated metabolic resistance as opposed to target-site alterations [16].…”