Multiple Liver Amoebic Abscesses Detected on FDG PET/CT

Cavaillolés, F.; Mure, Agnes; Nasser, Hicham; Lecapitaine, Anne-Lise; Granier, F

doi:10.1097/rlu.0b013e31828e98ad

Cited by 15 publications

(6 citation statements)

References 13 publications

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“…Both hepatic metastases and infection/abscess can demonstrate intense FDG uptake [44,45]. CT appearance, clinical history, and time course are key to differentiate them from metastatic lesions (Fig.…”

Section: Abdomen and Pelvismentioning

confidence: 99%

Acute Findings on FDG PET/CT: Key Imaging Features and How to Differentiate Them from Malignancy

Behr

2020

Curr Radiol Rep

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Purpose of review To review acute findings commonly encountered during routine clinical FDG PET/CT studies and present key imaging features to differentiate them from malignant counterparts. Recent findings FDG PET/CT is extensively used in routine clinical practice for oncology patients. Incidental acute findings in patients undergoing FDG PET/CT are increasingly common, and awareness of these findings and their mimics are important in delivering a clinically relevant and accurate radiological report for directing further management. Summary This article will review examples of common acute findings encountered during routine FDG PET/CT scans, compare them against examples of FDG-avid malignancy that can mimic these findings and emphasize key imaging findings to differentiate acute findings from their malignant mimics.

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Section: Abdomen and Pelvismentioning

confidence: 99%

Acute Findings on FDG PET/CT: Key Imaging Features and How to Differentiate Them from Malignancy

Behr

2020

Curr Radiol Rep

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“…However, sensitivity varies with the radiopharmaceutical utilized, technetium (80%), gallium (50-80%), and indium (90%). In addition, limitations include a delay in diagnosis and the need for confirmatory procedures; thus, they offer no benefit over other imaging modalities [28].…”

Section: Diagnosismentioning

confidence: 99%

The Silent Killer: A Case Report of Delayed Diagnosis and Successful Treatment of Pancreatic Trauma

Coral

2023

oajs

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Hepatic abscesses are suppurated cavities caused by the invasion and multiplication of microorganisms within the liver parenchyma. This condition is relatively uncommon, with an estimated incidence of 2.3 to 3.6 cases per 100,000 people yearly. However, the incidence is higher in specific populations, such as patients with underlying liver disease, diabetes, or other immune-compromising conditions. The most common cause of liver abscesses is the spread of infection from other parts of the body, such as the biliary tract or gastrointestinal tract. Other causes include trauma to the liver, such as from a penetrating injury or surgery or the presence of a foreign body in the liver. Liver abscesses are broadly divided into two types: amoebic and pyogenic. The clinical presentation might vary, including fever, abdominal pain, nausea and vomiting, jaundice, and weight loss. In some cases, there may be no symptoms. Diagnosis typically involves an ultrasound or CT scan, which can show the presence of a fluid-filled mass in the liver. CT is the standard modality for diagnosis. Blood tests may also evaluate liver function and identify any underlying infections. Treatment typically involves a combination of antibiotics to target the underlying infection and drainage of the abscess. Supportive measures like hydration and pain management may also be necessary. In addition, close monitoring and follow-up are essential to ensure that the abscess has resolved and there are no complications. In some cases, surgical intervention may be necessary to remove the abscess or repair any damage to the liver. Liver abscess drainage is typically indicated in patients with significant, symptomatic abscesses or those who do not respond to medical treatment with antibiotics. In addition, abscesses at risk of rupturing or located close to vital structures, such as major blood vessels, may require drainage to prevent serious complications. Two drainage methods are presently available: non-surgical options, such as percutaneous needle aspiration or percutaneous catheter drainage, and surgical options, such as open drainage or laparoscopic drainage. This review identifies when these alternatives should be used, taking adverse effects, symptoms, and comorbidities into account.

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“…The first report of hepatic amoebiasis from Sri Lanka, formerly known as Ceylon was way back in 1821 (10).Since then several reports have been published (8,11,12). Though a study had been conducted in Northern Sri Lanka on immunological and molecular confirmation of amoebiasis recently, diagnosis is mainly based on clinical and ultrasonographic findings (13).…”

Section: Amoebiasismentioning

confidence: 99%

Metronidazole for Amoebiasis: A tale of more than half a century

2021

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Metronidazole has many unique properties such as possessing antibacterial as well as anti-protozoal activity, very minimal resistance rate, acceptable safety profile and market longevity. Metronidazole has remained as the recommended drug in the treatment of any form of amoebiasis caused by Entamoeba histolytica since its inception almost half a century ago. Anaphylaxis which limits the use of many antibacterial agents is hardly reported with metronidazole accounting for its favourable safety profile. Owing to its low-cost, it is considered affordable and economically accessible in developing countries which are mainly affected by amoebiasis. Its pharmacokinetic properties considered are its asset as well as drawback. For example, good bioavailability and good tissue penetration allows metronidazole to be used as oral dosage form in many indications and responsible for its efficacy in many extra-intestinal amoebiasis. However, inhibition of hepatic drug metabolizing enzymes is responsible for some significant drug interactions, and disulfiram like effect with alcohol. Unlike many other antimicrobial agents which were discovered much later, metronidazole has withstood the problem of antimicrobial resistance. Even some longer acting agents have been developed in the recent past, metronidazole remains the drug of first choice for amoebiasis documenting very high cure rate with minimal need for other treatment modalities.

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Multiple Liver Amoebic Abscesses Detected on FDG PET/CT

Cited by 15 publications

References 13 publications

Acute Findings on FDG PET/CT: Key Imaging Features and How to Differentiate Them from Malignancy

Acute Findings on FDG PET/CT: Key Imaging Features and How to Differentiate Them from Malignancy

The Silent Killer: A Case Report of Delayed Diagnosis and Successful Treatment of Pancreatic Trauma

Metronidazole for Amoebiasis: A tale of more than half a century

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