2024
DOI: 10.31857/s0301179824040031
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Multiple mechanisms of allosteric regulation of the luteninizing hormone receptor

A. O. Shpakov,
K. V. Derkach

Abstract: The regulatory effects of luteinizing hormone (LH) and chorionic gonadotropin (CG) are realized through the activation of the G-protein coupled LH/CG receptor (LH/CG-R). The result of this is the activation of various types of G proteins, which leads to stimulation (Gs) or inhibition (Gi) of the cAMP-dependent pathway and stimulation of calcium signaling (Gq/11, Gi), and the recruitment of β-arrestins, which prevent G protein signaling through receptor internalization and downregulation, but can also activate … Show more

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