Multiple Myeloma and Acute Leukemia

Kastanas, George A.; C, Papaioannou; Nathena, Helen A.

doi:10.1159/000207543

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…A PUBMED database search was made for synchronous occurrence of AML with MM from 1970 to 2021 and data was analyzed 1 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Twin Malignancy of Acute Myeloid Leukemia and Multiple Myeloma in a Chemotherapy-Naïve Patient: A Rare Occurrence

2022

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“…A PUBMED database search was made for synchronous occurrence of AML with MM from 1970 to 2021 and data was analyzed 1 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Twin Malignancy of Acute Myeloid Leukemia and Multiple Myeloma in a Chemotherapy-Naïve Patient: A Rare Occurrence

2022

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“…However, we should be aware that at present karyograms do not enable us to detect subtle genetic aber rations. We have recently reported an other case with chronic granulocytic-line leukemia terminating in MM [26] and we stress the interest of all clinical associa tions between plasma cell neoplasms and myeloproliferative syndromes [27][28][29][30][31][32][33][34],…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilic Syndrome and Plasmocytoma

Franchi¹,

F²,

P³

et al. 1984

Acta Haematol

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The 4th case of plasma cell neoplasm associated with a hypereosinophilic syndrome is described and compared with the previous reports. Hypereosinophilia in the present patient displayed some borderline traits with eosinophilic leukemia. Myeloproliferative disorders of the eosinophilic line often present as a precancerous state, but sometimes they seem to acquire malignant independence. In our patient the occurrence of a plasmocytoma with a dramatic course leads to suspect an underlying complex genetic aberration.

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Trisomy 8 preceding diagnosis of acute nonlymphocytic leukemia by 2 years in a patient with multiple myeloma without cytological evidence of myelodysplasia

et al. 1996

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A case of acute nonlymphocytic leukemia (ANLL) occurring 2 years after the diagnosis of multiple myeloma (MM) that had been treated by only one course of melphalan/prednisone chemotherapy is reported. Cytogenetic and fluorescence in situ hybridization analysis of peripheral blood cells revealed trisomy 8 as the sole cytogenetic defect at the time of diagnosis of ANLL. Two years earlier, when MM was diagnosed without any cytological evidence of co-existent myelodysplasia, chromosomal analysis of bone marrow cells showed the same pathological karyotype 47, XY, +8 in 14 of 20 mitoses studied. Our interpretation of this unusual cytogenetic finding is that at the time of diagnosis of MM, in spite of lacking cytological signs of myelodysplasia, an unrecognizable myelodysplastic syndrome must have been present which then evolved to ANLL.

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Multiple Myeloma and Acute Leukemia

Cited by 10 publications

References 5 publications

Twin Malignancy of Acute Myeloid Leukemia and Multiple Myeloma in a Chemotherapy-Naïve Patient: A Rare Occurrence

Twin Malignancy of Acute Myeloid Leukemia and Multiple Myeloma in a Chemotherapy-Naïve Patient: A Rare Occurrence

Hypereosinophilic Syndrome and Plasmocytoma

Trisomy 8 preceding diagnosis of acute nonlymphocytic leukemia by 2 years in a patient with multiple myeloma without cytological evidence of myelodysplasia

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