Multiple myeloma presenting as bilateral breast lumps in pregnant woman

Bouzguenda, Racem; Khanfir, Afef; Toumi, Nabil; Chaaben, K.; Hentati, Yosr; Ayadi, Lobna; Feki, W.; Daoud, J.; Frikha, M.

doi:10.1007/s12185-013-1420-y

Cited by 6 publications

(12 citation statements)

References 10 publications

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“…ment, there are few case reports with nodular lesions of the deep or mammary glands [5,6,8,11]. In EMP cases with breast involvement, mammography and tomography findings have been observed nonspecific [5,6]. Examination of the tomography of our case revealed numerous well-defined hypoechoic heterogeneous opacities in the mammary.…”

Section: Case Reportmentioning

confidence: 46%

“…The patient was ex due to septic shock after pneumonia. ment, there are few case reports with nodular lesions of the deep or mammary glands [5,6,8,11]. In EMP cases with breast involvement, mammography and tomography findings have been observed nonspecific [5,6].…”

Section: Case Reportmentioning

confidence: 99%

“…Examination of the tomography of our case revealed numerous well-defined hypoechoic heterogeneous opacities in the mammary. In EMP, breast involvement is associated with poor prognosis [5,6,11]. Extramedullary MM has no standard treatment regimen.…”

Section: Case Reportmentioning

confidence: 99%

“…Skin and breast involvement can be seen at the time of diagnosis in MM as well as at the time of treatment or relapse. Never the less, metastatic cutaneous and breast lesions may develop without bone marrow involvement, rarely [2][3][4][5][6]. We aimed to present a very rare case of a seventy-year-old female patient who have multiple myeloma with breast and skin involvement, independently from treatment.…”

Section: Introductionmentioning

confidence: 99%

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Multiple Myeloma with Skin and Breast Involvement: A Case Report

Pektaş¹,

Pektaş²,

Tetik³

et al. 2017

Dermatol Arch

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Multiple myeloma; that constitutes 10% of all hematologic malignancies and approximately 1% of whole cancers, is a plasma cell dyscrasia. Extramedullary involvement is often seen in the upper skeletal system, besides it can be seen on the skin and breast, rarely. Extramedullary involvement is generally limited to a single organ. In this article, we present a 70-year-old woman with recurrent skin and breast involvement after multiple treatment with MM diagnosis.

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Section: Case Reportmentioning

confidence: 46%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multiple Myeloma with Skin and Breast Involvement: A Case Report

Pektaş¹,

Pektaş²,

Tetik³

et al. 2017

Dermatol Arch

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“…The most frequently reported symptoms in gestants with MM are bone pain and anaemia. . Here we describe a new case and perform a thorough literature review.…”

Section: Discussionmentioning

confidence: 99%

‘Management multiple myeloma during pregnancy: a case report and review’

Cabañas-Perianes

Macizo

Salido

et al. 2014

Hematological Oncology

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Multiple myeloma (MM) is a hematologic neoplasm characterized by plasma tumor cell proliferation in the bone marrow. It's a rare malignancy before a 40-year-old and it is extremely uncommon during pregnancy. We report the case of a 37-year-old woman with a newly diagnosed IgG λ MM (Durie-Salmon stage IIIA, International Staging System II and good prognosis cytogenetic) at the 27th week of her pregnancy. Our management during pregnancy, the delivery, and initiation of anti-myeloma treatment with bortezomib, lenalidomide, and dexamethasone are published. There are a few reviews reporting the most common features and management of MM during pregnancy. We perform a comprehensive review of all 32 cases reported between 1965 and 2014 in which a MM was diagnosed during pregnancy including score, cytogenetic results, labor characteristics, and response to therapy. About 53% of pregnant women did not start treatment before partum. Cesarean section was the most common form of delivery (82%). About 88% of newborns were healthy, although most of them were premature (73%). Management of a MM diagnosed during pregnancy should be based on the presence of myeloma-related organ damage to secure survival of the mother without fetal adverse effects related to treatment. Serial fetal ultrasound may be helpful in order to avoid complications. The cesarean section may be preferred depending on maternal and fetus prognosis. Whole-body diffusion-weighted imaging minimal response could be an appropriate technique to discard plasmacytomas during pregnancy in critical situations such as the appearance of symptoms of spinal cord compression. Therapeutic choices should be agreed with the pregnant after a thorough discussion of the prognostic factors of the disease and the potential risk for the fetus and the patient. While awaiting partum, dexamethasone is a non-toxic treatment. Triple therapy including a proteasome inhibitor should be started quickly after delivery. Copyright © 2014 John Wiley & Sons, Ltd.

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