Multiple myeloma with concurrent immune thrombocytopenic purpura

Abstract

Multiple myeloma (MM) is the second most common haematological malignancy in the USA. MM has been linked to various autoimmune disorders in many studies; one systemic review even suggested an increased risk of MM among patients with autoimmune disorders. MM is associated with many haematological, rheumatologic and neurological conditions. A few case reports suggest that MM can be associated with immune thrombocytopenic purpura (ITP), although this is rare. We present a case of MM with concurrent ITP which was refractory of steroids and intravenous immunoglobulin but had a response with anti-neoplastic therapy for MM. We also review all the cases of ITP with MM described in the literature. If conventional treatment for ITP associated with MM fails to improve platelet count, anti-neoplastic therapy for MM should be considered.

Immune Thrombocytopenia in a Very Elderly Patient With Covid-19

“…Peripheral blood confirmed the presence of thrombocytopenia. Given the very old age of the patient and a possible association with multiple myeloma (MM) and ITP, immunoglobulin levels, serum and urine immunofixation and protein electrophoresis were checked and all were found to be within normal ranges (7). Bone marrow aspiration revealed a normocellular bone marrow with concomitant increase in normal sized megakaryocytes.…”

Successful Treatment of Steroid-Refractory Immune Thrombocytopenia in a Patient Developing Multiple Myeloma While on Immune Checkpoint Inhibitor Therapy for Lung Cancer: A Case Report

“…Instances of ITP related to MM are rare, 12 and the concurrent diagnosis of both conditions is even less common. 13 Interestingly, in cases where ITP is linked to MM, the M-protein is typically IgG. 13 In this case, ITP due to MM could not be excluded as a potential cause of the patient’s thrombocytopenia.…”

A Case Report: Monoclonal Gammopathy of Undetermined Significance Presenting With Renal Amyloidosis and Reactive Thrombocytosis

“…Thrombocytopenia is a joint presentation in patients with plasma cell dyscrasias. Pathogenesis is typically due to bone marrow replacement by the transformed cells or follows treatment with chemotherapy [ 7 ]. Our presented case demonstrates a rare CBC finding like thrombocytosis where the patient also developed renal amyloidosis, which boosts the confirmation of MGUS diagnosis.…”