Multiple nodular pulmonary amyloidosis. A case report and comparison with diffuse alveolar-septal pulmonary amyloidosis.

Lee, Siong-Chuan; Johnson, Harvey L.

doi:10.1136/thx.30.2.178

Cited by 40 publications

(7 citation statements)

References 26 publications

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“…Amyloidosis may present to respiratory physicians in a variety of ways. As with previously reported cases of localized nodular pulmonary amyloidosis, the three patients have had a benign course 4–7 . Hui et al showed that the amyloid in the majority of these cases is derived from monoclonal immunoglobulins (AL amyloid) 2 .…”

Section: Discussionsupporting

confidence: 65%

Pulmonary presentations of amyloidosis

Ireton¹,

Daniels

Langton

et al. 2001

Respirology

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Pulmonary presentations of amyloidosis HOWARD ME, IRETON J, DANIELS F, LANGTON D, MANOLITSAS ND, FOGARTY P, MCDONALD CF. Respirology 2001; 6: 61-64. Abstract: Respiratory tract involvement with amyloid is rare. We report eight cases of lower respiratory tract amyloidosis including a case of isolated pulmonary interstitial amyloidosis treated with chemotherapy, two cases of recurrent endobronchial amyloid with airway obstruction successfully treated with laser therapy and three cases of localized nodular pulmonary amyloidosis. The subjects with endobronchial and nodular amyloid demonstrated good long-term survival, while those with systemic or interstitial pulmonary amyloid had progressive disease and poor survival. Circulating monoclonal immunoglobulins were identified in five of the eight cases as the likely cause of the amyloid.

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Section: Discussionsupporting

confidence: 65%

Pulmonary presentations of amyloidosis

Ireton¹,

Daniels

Langton

et al. 2001

Respirology

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“…As with previously reported cases of localized nodular pulmonary amyloidosis, the three patients have had a benign course. [4][5][6][7] Hui et al showed that the amyloid in the majority of these cases is derived from monoclonal immunoglobulins (AL amyloid). 2 Pulmonary amyloid nodules are associated with local clusters of plasma and giant cells.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary presentations of amyloidosis

Ireton¹,

Daniels²,

Langton³

et al. 2001

Respirology

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Respiratory tract involvement with amyloid is rare. We report eight cases of lower respiratory tract amyloidosis including a case of isolated pulmonary interstitial amyloidosis treated with chemotherapy, two cases of recurrent endobronchial amyloid with airway obstruction successfully treated with laser therapy and three cases of localized nodular pulmonary amyloidosis. The subjects with endobronchial and nodular amyloid demonstrated good long-term survival, while those with systemic or interstitial pulmonary amyloid had progressive disease and poor survival. Circulating monoclonal immunoglobulins were identified in five of the eight cases as the likely cause of the amyloid.

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“…Tracheobronchial amyloidosis, most often presenting as multifocal submucosal plaques, is an organ-limited type of amyloidosis, which is usually not associated with detectable systemic lymphoplasmacytic clonal proliferation [28,29,44,47,59,[68][69][70][71][72]. The association with multiple myeloma is extremely rare [73].…”

Section: Tracheobronchial Amyloidosismentioning

confidence: 99%

The lung in amyloidosis

et al. 2017

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Amyloidosis is a disorder caused by misfolding of autologous protein and its extracellular deposition as fibrils, resulting in vital organ dysfunction and eventually death. Pulmonary amyloidosis may be localised or part of systemic amyloidosis.Pulmonary interstitial amyloidosis is symptomatic only if the amyloid deposits severely affect gas exchange alveolar structure, thus resulting in serious respiratory impairment. Localised parenchymal involvement may be present as nodular amyloidosis or as amyloid deposits associated with localised lymphomas. Finally, tracheobronchial amyloidosis, which is usually not associated with evident clonal proliferation, may result in airway stenosis.Because the treatment options for amyloidosis are dependent on the fibril protein type, the workup of all new cases should include accurate determination of the amyloid protein. Most cases are asymptomatic and need only a careful follow-up. Diffuse alveolar-septal amyloidosis is treated according to the underlying systemic amyloidosis. Nodular pulmonary amyloidosis is usually localised, conservative excision is usually curative and the long-term prognosis is excellent. Tracheobronchial amyloidosis is usually treated with bronchoscopic interventions or external beam radiation therapy.

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Multiple nodular pulmonary amyloidosis. A case report and comparison with diffuse alveolar-septal pulmonary amyloidosis.

Cited by 40 publications

References 26 publications

Pulmonary presentations of amyloidosis

Pulmonary presentations of amyloidosis

Pulmonary presentations of amyloidosis

The lung in amyloidosis

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