Multiple-organ effect of normobaric hyperoxia in neonatal rats

Torbati, Dan; Tan, Gim H.; Smith, Stanley M.; Frazier, Kendall S.; Gelvez, Javier; Fakioglu, Harun; Totapally, Balagangadhar

doi:10.1016/j.jcrc.2005.09.057

Cited by 32 publications

(20 citation statements)

References 28 publications

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“…What happens to the fetus, and logically also to a baby in the NICU during what would have been his or her third trimester, has important effects on later overall health and development. For example, simple hyperoxia exposure in the neonatal rodent results in adverse effects on the heart, kidney, and lungs, as well as deficits in spatial and recognition memory (33)(34)(35)(36)(37)(38). The type of mechanical ventilation utilized in preterm sheep influences not only lung development, but also affects brain function later in life (39,40).…”

Section: Review Day and Ryanmentioning

confidence: 99%

Bronchopulmonary dysplasia: new becomes old again!

2016

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Despite the many advances in neonatology, bronchopulmonary dysplasia (BPD) continues to be a frustrating disease of prematurity. BPD is a disease which is defined oddly by its treatment rather than its pathophysiology, leading to frequently changing nomenclature which has widespread implications on our ability to both understand and follow the progression of BPD. As various treatment modalities for BPD were developed and a larger number of extremely preterm infants survived, the "old" BPD based on lung injury from oxygen therapy and mechanical ventilation transitioned into a "new" BPD focused more on the interruption of normal development. However, the interruption of normal development does not solely apply to lung development. The effects of prematurity on vascular development cannot be overstated and pulmonary vascular disease has become the new frontier of BPD. As we begin to better understand the complex, multifactorial pathophysiology of BPD, it is necessary to again focus on appropriate, pathology-driven nomenclature that can effectively describe the multiple clinical phenotypes of BPD.

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Section: Review Day and Ryanmentioning

confidence: 99%

Bronchopulmonary dysplasia: new becomes old again!

2016

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“…Prior studies have demonstrated various short- and long-lasting effects of short-term as well as long-term hyperoxia on several organs [ 4 , 5 , 7 , 8 ], including the kidney [ 6 ]. However, the results of several recent studies are inconclusive [ 13 , 14 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…While hyperoxia of various organs (e.g., lungs, brain, or retina) has been investigated sufficiently in recent years [ 4 , 5 ], molecular effects and pathway alterations in renal tissue and kidneys due to hyperoxia are rarely studied. Whereas there is growing evidence that normobaric hyperoxia has significant effects in preterm or neonatal kidneys [ 6 , 7 ], data for adults are lacking.…”

Section: Introductionmentioning

confidence: 99%

Hyperoxia-Induced Protein Alterations in Renal Rat Tissue: A Quantitative Proteomic Approach to Identify Hyperoxia-Induced Effects in Cellular Signaling Pathways

et al. 2015

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Introduction. In renal tissue as well as in other organs, supranormal oxygen pressure may lead to deleterious consequences on a cellular level. Additionally, hyperoxia-induced effect in cells and related free radicals may potentially contribute to renal failure. The aim of this study was to analyze time-dependent alterations of rat kidney protein expression after short-term normobaric hyperoxia using proteomics and bioinformatic approaches. Material and Methods. N = 36 Wistar rats were randomized into six different groups: three groups with normobaric hyperoxia (exposure to 100% oxygen for 3 h) and three groups with normobaric normoxia (NN; room air). After hyperoxia exposure, kidneys were removed immediately, after 3 days and after 7 days. Kidney lysates were analyzed by two-dimensional gel electrophoresis followed by peptide mass fingerprinting using tandem mass spectrometry. Statistical analysis was performed with DeCyder 2D software (p < 0.01). Biological functions of differential regulated proteins were studied using functional network analysis (Ingenuity Pathways Analysis and PathwayStudio). Results. Expression of 14 proteins was significantly altered (p < 0.01): eight proteins (MEP1A_RAT, RSSA_RAT, F16P1_RAT, STML2_RAT, BPNT1_RAT, LGMN_RAT, ATPA_RAT, and VDAC1_RAT) were downregulated and six proteins (MTUS1_RAT, F16P1_RAT, ACTG_RAT, ACTB_RAT, 2ABA_RAT, and RAB1A_RAT) were upregulated. Bioinformatic analyses revealed an association of regulated proteins with inflammation. Conclusions. Significant alterations in renal protein expression could be demonstrated for up to 7 days even after short-term hyperoxia. The identified proteins indicate an association with inflammation signaling cascades. MEP1A and VDAC1 could be promising candidates to identify hyperoxic injury in kidney cells.

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“…However, hyperoxia also enhances the inflammatory response in adult mice infected with influenza A virus (27). It has been proposed that normobaric hyperoxia might affect certain peripheral organs (kidney, ileum) (8). The thickness of the ileal mucosa of neonatal rats under conditions leading to hyperoxia was significantly greater (9).…”

Section: Discussionmentioning

confidence: 99%

“…There have been some reports about the effect of hyperoxia on intestinal epithelial cells in vitro (5)(6)(7). In vivo, hyperoxia creates intestinal serosal and submucosal vasodilation, vascularization, and growth retardation in neonatal rats (8). Because the intestinal villi and mucosa continue to grow and differentiate after birth, the long-term effects of postnatal hyperoxia exposure may be most relevant to the human infant (9).…”

mentioning

confidence: 99%

Effect of hyperoxia on the intestinal IgA secretory component in neonatal rats and on intestinal epithelial cells in vitro

Dy¹,

2010

Braz J Med Biol Res

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Multiple-organ effect of normobaric hyperoxia in neonatal rats

Cited by 32 publications

References 28 publications

Bronchopulmonary dysplasia: new becomes old again!

Bronchopulmonary dysplasia: new becomes old again!

Hyperoxia-Induced Protein Alterations in Renal Rat Tissue: A Quantitative Proteomic Approach to Identify Hyperoxia-Induced Effects in Cellular Signaling Pathways

Effect of hyperoxia on the intestinal IgA secretory component in neonatal rats and on intestinal epithelial cells in vitro

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