Multiple Pacinian neurofibroma and relationship with the finger-tip arterio-venous anastomoses

Abstract

Multiple Pacinian neurofibromas involving the three phalanges of the ring finger of the left hand in a 60-year-old woman are described. The abnormal proliferation of Vater-Pacini corpuscles in various stages of differentiation was associated with marked changes of the glomus type of arterio-venous anastomoses of the finger-tip. The close relationship between the new proliferated Vater-Pacini corpuscles, their altered baresthetic function and the pathological shunting of blood account for the painful Raynaud-like symptoms. The name 'Pacinian neurofibromatosis' is proposed.

Pacinian Neurofibroma of Scalp

“…Pacinian neurofibromas are usually seen in solitary forms but McCormack et al came across multiple tumours of buttocks [8] and Levi and Curi have also reported multiple neurofibromas of fingers in form of pacinian neurofibromatosis [9]. These benign tumours usually lack cellular pleomorphism and mitotic figures but King and Barr reported a case of pacinian neurofibroma with cellular pleomorphism and mitotic figures and proposed a new term for such forms as 'bizarre cutaneous neurofibromas' [10].…”

Pacinian neurofibroma: A rare neurogenic tumor

“…[1] It usually occurs as a solitary nodule, most often on the hands and feet, where Pacinian corpuscles are usually concentrated. [2,3] Lesions may occur elsewhere also. [1,2] Diagnosis is established by histopathology features, which may be variable.…”

“…[2,3] Lesions may occur elsewhere also. [1,2] Diagnosis is established by histopathology features, which may be variable. We report a case of PN which presented as a slowly growing tumor on the forearms.A 17-year-old boy presented with an asymptomatic, well-defined, irregular, sessile, slow-growing tumor [ Figure 1] on the extensor aspect of right forearm of 3 years duration.…”

“…[6] PN usually presents as solitary, firm, well-marginated, mobile nodule. [1,2] Multiple lesions are rare. [1] Other morphological pattern that have been described in PN are papular lesions, ulcerated tumor, pedunculated nodule, multiple soft plaques, or just surface pigmentation.…”

A Rare Case of Pacinian Corpuscle Neuroma

“…Pacinian corpuscle neuromas may be associated with other lesions such as glomus tumour, Dupuytren's contracture, multiple Pacinian neuroma and arteriovenous anastomoses (14)(15)(16).…”