Multiple passive element enriched photoacoustic computed tomography

Resink, Steffen; Jose, Jithin; Willemink, Rene G. H.; Slump, Cornelis H.; Steenbergen, Wiendelt; Leeuwen, Ton G. van; Manohar, Srirang

doi:10.1364/ol.36.002809

Cited by 17 publications

(16 citation statements)

References 8 publications

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“…Another possibility is the laser-US (LUS) method, where PA US excitation is used for the generation of the incoming sound waves, facilitating simultaneous dual-mode PA and US imaging. Manohar et al 18 and Resink et al 19 used the same light source for PA and US excitations by placing external absorbing targets in the path of the illuminating laser pulses. LUS waves generated at these absorbers traversed the sample and were detected by an array of piezoelectric sensors, together with photoacoustically excited sound waves from inside the sample.…”

Section: Introductionmentioning

confidence: 99%

Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection

2016

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, "Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection," J. Biomed. Opt. Abstract. A purely optical setup for the coregistration of photoacoustic (PA), ultrasound (US), and speed-ofsound (SOS) section images is presented. It extends a previously developed method for simultaneous PA and laser-US (LUS) pulse-echo imaging with a LUS transmission imaging setup providing two-dimensional (2-D) SOS maps. For transmission imaging, the sound waves traversing the investigated object are generated instantaneously by illuminating optically absorbing targets that are arranged at various distances in front of the sample. All signals are recorded by an optical beam which is part of a Mach-Zehnder interferometer that integrates the acoustic field along its path. Due to the cascaded arrangement of LUS sources, a single-recorded signal yields information for a projection of the SOS distribution. After collection of data from all directions, an inverse Radon transform is applied to this set of projections to obtain a 2-D SOS image. The setup is characterized and its performance is tested on phantom experiments. In addition to providing additional contrast, it is also shown that the resolution of the coregistered PA and LUS images can be improved by implementing the knowledge of the SOS distribution in the reconstruction. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection

2016

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“…Nuster et al used this method for hybrid PA and US section imaging with focused detection to obtain coregistered 2D images [15]. Various researchers proposed setups for hybrid PA and LUStransmission imaging [16][17][18][19]. Manohar et al, for example, placed a small absorber into the illuminating laser path so that still enough light fell onto the imaging object for PA excitation [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Various researchers proposed setups for hybrid PA and LUStransmission imaging [16][17][18][19]. Manohar et al, for example, placed a small absorber into the illuminating laser path so that still enough light fell onto the imaging object for PA excitation [16][17][18]. Behind the sample a transducer array was arranged to measure the transmitted US signal and the PA signals emitted by the target.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous three-dimensional photoacoustic and laser-ultrasound tomography

Wurzinger

Nuster

Schmitner

et al. 2013

Biomed. Opt. Express

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A tomographic setup that provides the co-registration of photoacoustic (PA) and ultrasound (US) images is presented. For pulseecho US-tomography laser-induced broadband plane ultrasonic waves are produced by illuminating an optically absorbing target with a short near-infrared laser pulse. Part of the same pulse is frequency doubled and used for the generation of PA waves within the object of interest. The laser-generated plane waves are scattered at the imaging object and measured with the same interferometric detector that also acquires the photoacoustic signals. After collection and separation of the data image reconstruction is done using back-projection resulting in threedimensional, co-registered PA and US images. The setup is characterized and the resolution in PA and US mode is estimated to be about 85 µm and 40 µm, respectively. Besides measurements on phantoms the performance is also tested on a biological sample.

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“…In this work, we use an approach based on speed-of-sound (SOS) tomography in a photoacoustic (CT) imager 15 to image and monitor spatiotemporal evolution of temperature without recourse to the Grüneisen coefficient. We make use of the known temperature sensitivity of the SOS.…”

Section: Introductionmentioning

confidence: 99%

“…As passive elements, we used eight horsetail hairs with a diameter of 200 to 250 μm positioned in such a way that the object lies completely within the fanbeam traced by the line of sight from the passive element to the edge detector elements for all projections, as discussed in Ref. 15. The signal detected from the passive element of 200 to 250 μm is typically dominated by the detector center frequency and bandwidth.…”

Section: Introductionmentioning

confidence: 99%

Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic–ultrasound transmission tomography

Daoudi¹,

Es²,

Manohar³

et al. 2013

J. Biomed. Opt

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Abstract. Recently, we presented an add-on to a photoacoustic (PA) computed tomography imager that permits the simultaneous imaging of ultrasound (US) transmission parameters such as the speed of sound (SOS), without additional measurements or instruments. This method uses strong absorbers positioned outside the object in the path of light for producing laser-induced US to interrogate the object in a conventional PA imager. Here, we investigate the feasibility of using this approach, first with PA to pin-point the location of photothermal therapeutic agents and then with serial SOS tomograms to image and monitor the resulting local temperature changes when the agents are excited with continuous wave (CW) light. As the object we used an agar-based tissue-mimicking cylinder carrying beads embedded with different concentrations of gold nanospheres. PA and SOS tomograms were simultaneously acquired as the gold nanospheres were photothermally heated using a 532-nm CW laser. In a first approximation, using the relation between SOS of water and temperature, the SOS tomograms were converted into temperature maps. The experimental results were verified using simulations: Monte Carlo modeling of light propagation through a turbid medium and using the obtained absorbed energy densities in heat diffusion modeling for spatial temperature distribution.

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Multiple passive element enriched photoacoustic computed tomography

Cited by 17 publications

References 8 publications

Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection

Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection

Simultaneous three-dimensional photoacoustic and laser-ultrasound tomography

Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic–ultrasound transmission tomography

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