Multiple peripheral arterial and aortic aneurysms in Behcet’s syndrome—a case report

Jayachandran, Nambiar Veettil; Rajasekhar, Liza; Chandrasekhara, Pradeep Kumar Shenoy; Kanchinadham, S; Narsimulu, G

doi:10.1007/s10067-007-0713-z

Cited by 29 publications

(24 citation statements)

References 6 publications

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“…Cure time was 6.4±5.5 (range: 2-24; median: 5) months (n=18). 14,25,34,38,46,47,54,56,59,61,63,65,73,81,91,95,113,116 In 11 cases PAA embolization materials were described, as follows: N-butyl cyanoacrylate (n=3, 27.3%), 34,41 Nester® Embolization Coils (n=3, 27.3%), 74,76 Amplatzer devices (n=3, 27.3%), 64,66,72 Ethylene Vinyl Alcohol Copolymer (n=1, 9.1%) 71 and Guglielmi detachable coils (n=1, 9.1%). 60 In patients with multiple PAAs, the number of embolization coils deployed in a single patient varied from 2, 74 through 6, 74 to 10.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary artery aneurysms in Behçet disease

Yuan

2014

J. vasc. bras.

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Pulmonary artery aneurysms (PAAs) are the most common type of pulmonary involvement in Behçet' s disease. However, the relationships between clinical features and prognosis have not been sufficiently evaluated. This article describes the results of a comprehensive review, revealing that PAAs have a predilection for hemoptysis manifestations, increased dimensions, right lower lobar location, multiplicity and concurrent intramural thrombus formation. Surgical intervention was needed in one third of patients. Patients with massive hemoptysis and PAA rupture warranted emergency operations. Conservatively treated patients were prone to PAA progression; interventional embolization was associated with higher risks of recurrence and reintervention for PAAs; and surgically treated patients exhibited the highest mortality rates. In conclusion, PAAs in Behçet' s disease are characterized by a predilection for hemoptysis manifestations, right lower lobar location, multiplicity, and concurrent intramural thrombus formation. Both the condition itself and the surgical operations it warrants are linked with high mortality due to PAA hemorrhage.Keywords: hemoptysis; therapeutic embolization; vasculitis. ResumoOs aneurismas das artérias pulmonares (PAA) são as manifestações mais comuns dos pulmões na doença de Behçet. No entanto, as relações entre as características clínicas e o prognóstico ainda não foram devidamente explicadas. O objetivo do presente artigo foi fazer uma ampla revisão da literatura sobre esta questão. As fontes de dados contaram com uma ampla revisão bibliográfica dos anos de 1990 a 2013, sobre os seguintes temas: doença de Behçet, síndrome de HughesStovin, aneurisma de artéria pulmonar e pseudoaneurisma da artéria pulmonar. Os PAA evoluíram com predileção por hemoptise, aumento de dimensões, localização no lobo inferior direito, multiplicidade e formação de trombo intramural. A intervenção cirúrgica foi necessária em um terço dos pacientes. O tratamento cirúrgico emergencial foi indicado na vigência de ruptura do PAA e de hemoptise maciça. Os pacientes tratados conservadoramente evoluíram com propensão para a progressão do PAA. A embolização dos PAA foi associada a uma taxa maior de recidiva e de reintervenção. Houve diferença significativa entre os grupos quanto às taxas de mortalidade, tendo o grupo do tratamento cirúrgico apresentado a maior taxa. Dentre as variáveis citadas, a hemoptise, o envolvimento da artéria lobar e a ruptura do PAA foram fatores preditivos de maior risco de mortalidade. Houve diferenças significativas nas taxas de mortalidade entre os pacientes cirúrgicos e intervencionistas, e entre os três grupos de pacientes: cirúrgico, intervencionista e conservador. Os pacientes tiveram uma sobrevida global de 61,7% em um seguimento médio de 22,5 meses. Os PAA, na doença de Behçet, apresentaram as seguintes predileções: tendência a hemoptise, multiplicidade, localização no lobo inferior direito e presença de trombos intramurais. As rupturas e hemorragias dos PAA, aliadas ao necessário tr...

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Section: Resultsmentioning

confidence: 99%

Pulmonary artery aneurysms in Behçet disease

Yuan

2014

J. vasc. bras.

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“…Also in the same study, it is stated that Leptin could be involved in non-specific repair mechanisms of damaged endothelia as well. The amount of leptin in circulation might be associated with the severity of immune system activation, and this could be used as a biomarker for the severity of BD [9].…”

Section: Discussionmentioning

confidence: 99%

Visfatin Levels in Behcet’s Disease

et al. 2011

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The aim of our study is to determine the serum visfatin levels of patients with Behcet's disease and to investigate the relationship between visfatin, an adipokine released from adipose tissue, levels and activity of Behcet's disease. Fifty-eight patients with Behcet's disease were enrolled to the study. Nineteen of the patients were inactive, and 39 of them were active. We enrolled 30 healthy subjects as being control group. Visfatin and tumor necrosis factor alpha (TNF-α) levels were measured with ELISA method. Visfatin levels were significantly lower in patients with Behcet's disease whose illnesses were active or inactive than the control group (p < 0.05). There was no significant difference between the active patient and inactive patient group. The reason for the lower levels of serum visfatin in active and inactive patients' group could be due to pro-inflammatory cytokines such as TNF-α and IL-6 which suppress genetic expression of visfatin in patients with Behcet's disease, or else.

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“…They are generally accompanied by venous thromboses [73]. Arterial lesions may be asymptomatic depending on the sufficiency of the collateral circulation or may present with ischemic symptoms.…”

Section: Occlusive Lesionsmentioning

confidence: 99%

Vascular Manifestations of Behçet’s Disease

Demïrtürk¹,

Tünel²,

Alemdaroğlu³

2017

Behcet's Disease

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Behçet's disease (BD), a very morphologically diverse systemic disease, may involve the vascular system. The venous system is the most frequently attacked vessel system.The arterial system, when involved, increases the severity and morbidity of Behçet's disease. Cardiac involvement, although rare, can be very subtle and in itself increases the mortality. Vasculitis is the hallmark pathology resulting in occlusion, aneurysms, or both.Vascular involvement may be very challenging in all phases of treatment beginning from diagnosis till recovery and remission.

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Multiple peripheral arterial and aortic aneurysms in Behcet’s syndrome—a case report

Cited by 29 publications

References 6 publications

Pulmonary artery aneurysms in Behçet disease

Pulmonary artery aneurysms in Behçet disease

Visfatin Levels in Behcet’s Disease

Vascular Manifestations of Behçet’s Disease

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