Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?

Mariet, Anne‐Sophie; Mauny, Frédéric; Pujol, Sophie; Thiriez, Gérard; Shrivastava, Paul; Riethmuller, Didier; Boilleaut, Mathieu; Defrance, Jérôme; Houot, Hélène; Parmentier, Anne-Laure; Vasseur-Barba, Marie; Benzenine, Éric; Quantin, Catherine; Bernard, Nadine

doi:10.1016/j.envint.2018.10.015

Cited by 26 publications

(35 citation statements)

References 47 publications

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“…The same inputs were used for the two models: meteorological observations, topographic data, shape, size, height and position of both roads and buildings, railway and road traffic data for each segment of the city 32 . Maps of night noise levels and NO 2 levels have been modeled at the city scale, using the MITHRA-SIG (noise), Circul’Air and ADMS-Urban (air) softwares 21,22,33,34 . Both noise and NO 2 maps have been validated by measurement campaigns.…”

Section: Methodsmentioning

confidence: 99%

“…The last decade provide an increasing evidence of the link between environment and pregnancy outcome. A higher risk of fetal growth restriction in relation to air pollution exposure was reported by main of the studies dealing with carbon monoxide (CO), nitrogen dioxide (NO 2 ) or particulate matter (PM 10 , PM 2.5 ) 18–21 . Effects on PTB appears to be more discussed 18–20,22 .…”

Section: Introductionmentioning

confidence: 98%

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Pregnancy vulnerability in urban areas: a pragmatic approach combining behavioral, medico-obstetrical, socio-economic and environmental factors

Brembilla

Bernard

Pujol

et al. 2019

Sci Rep

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Multiple risk factors are associated with adverse pregnancy outcomes (APO), but how all these different factors combine and accumulate remains unknown. The objective of this observational retrospective study was to describe the accumulation of multiple vulnerability markers in pregnant women living in an urban area. Women living in Besançon (France) who delivered between 2005 and 2009 were included. Individual data were collected from the obstetrical records while environmental exposures were collected using environmental prediction models. The accumulation of 15 vulnerability markers, grouped into six dimensions (maternal age, smoking, body mass index (BMI), socio-economic, medico-obstetrical and environmental vulnerabilities) was described and analyzed in comparison with four APO. Among the 3686 included women, 20.8% were aged under 20 or over 34 and 21.9% had an extreme pre-pregnancy BMI. 18.8% declared smoking during pregnancy. Women exposed to socio-economic, medico-obstetrical or environmental vulnerability were 14.2%, 31.6% and 42.4% respectively. While 20.6% were not exposed to any marker, 18.8% accumulated three or more dimensions. The risk of APO increased significantly with the cumulative number of vulnerabilities. Define and validate a vulnerability score could be useful to identify vulnerable women, adapt their pregnancy monitoring and help policy makers to implement appropriate education or health promotion programs.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Pregnancy vulnerability in urban areas: a pragmatic approach combining behavioral, medico-obstetrical, socio-economic and environmental factors

Brembilla

Bernard

Pujol

et al. 2019

Sci Rep

Self Cite

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“…Environmental residential exposures. The residential exposure assessments have been previously described 10,[33][34][35][46][47][48][49][50] . The participants' addresses at the date of delivery were extracted from CPage software (ver-sion 2, https:// www.…”

Section: Covariablesmentioning

confidence: 99%

Association between moderated level of air pollution and fetal growth: the potential role of noise exposure

Mariet

Bernard

Pujol

et al. 2021

Sci Rep

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This study aims to analyze, in a population of singletons, the potential confounding or modifying effect of noise on the relationship between fetal growth restriction (FGR) or small for gestational age (SGA) and environmental exposure to air pollution. All women with single pregnancies living in one of two medium-sized cities (Besançon, Dijon) and who delivered at a university hospital between 2005 and 2009 were included. FGR and SGA were obtained from medical records. Outdoor residential exposure to nitrogen dioxide (NO2) and particulate matter (PM10) was quantified at the mother’s address at delivery over defined pregnancy periods; outdoor noise exposure was considered to be the annual average daily noise levels in the façade of building (LAeq,24 h). Adjusted odds ratios (ORa) were estimated by multivariable logistic regressions. Among the 8994 included pregnancies, 587 presented FGR and 918 presented SGA. In the two-exposure models, for SGA, the ORa for a 10-µg/m3 increase of PM10 during the two last months before delivery was 1.18, 95%CI 1.00–1.41 and for FGR, these ORa were for the first and the third trimesters, and the two last months before delivery: 0.77 (0.61–0.97), 1.38 (1.12–1.70), and 1.35 (1.11–1.66), respectively. Noise was not associated with SGA or FGR and did not confound the relationship between air pollution and SGA or FGR. These results are in favor of an association between PM10 exposure and fetal growth, independent of noise, particularly towards the end of pregnancy, and of a lack of association between noise and fetal growth.

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“…Although this region's air pollution levels are lower than other, more densely populated areas of the world, lying well below the EU air quality guidelines and mostly under targets proposed by WHO [51], adverse health outcomes have been identified even at low exposure concentrations. This is especially true for vulnerable populations, such as pregnant women and their babies [33,43,46,51,58]. Furthermore, Scania is of particular interest as it has relatively high levels of air pollution compared to the rest of Sweden [19,57].…”

Section: Study Settingmentioning

confidence: 99%

“…Furthermore, neither of these previous studies focused on pregnant women, a more susceptible population, nor did they include PM exposure in their analyses. As the harmful effects of air pollution's many components on maternal health [40][41][42][43] and fetal development [33,46,47,51], even below EU and WHO air quality thresholds, are well documented, it is vital to learn of pregnant women's exposure in Scania, a relatively low-exposure setting. Air pollution levels in this region underwent a general decline in recent years [56], yet whether associations between air pollution exposure and SES have varied over time remains to be explored.…”

Section: Introductionmentioning

confidence: 99%

Connecting Air Pollution Exposure to Socioeconomic Status: A Cross-Sectional Study on Environmental Injustice among Pregnant Women in Scania, Sweden

Flanagan

Oudin

Malmqvist

2019

IJERPH

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Environmental injustice, characterized by lower socioeconomic status (SES) persons being subjected to higher air pollution concentrations, was explored among pregnant women in Scania, Sweden. Understanding if the general reduction of air pollution recorded is enjoyed by all SES groups could illuminate existing inequalities and inform policy development. “Maternal Air Pollution in Southern Sweden”, an epidemiological database, contains data for 48,777 pregnancies in Scanian hospital catchment areas and includes births from 1999–2009. SES predictors considered included education level, household disposable income, and birth country. A Gaussian dispersion model was used to model women’s average NOX and PM2.5 exposure at home residence over the pregnancy period. Total concentrations were dichotomized into emission levels below/above respective Swedish Environmental Protection Agency (EPA) Clean Air objectives. The data were analyzed using binary logistic regression. A sensitivity analysis facilitated the investigation of associations’ variation over time. Lower-SES women born outside Sweden were disproportionately exposed to higher pollutant concentrations. Odds of exposure to NOX above Swedish EPA objectives reduced over time, especially for low-SES persons. Environmental injustice exists in Scania, but it lessened with declining overall air pollution levels, implying that continued air quality improvement could help protect vulnerable populations and further reduce environmental inequalities.

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Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?

Cited by 26 publications

References 47 publications

Pregnancy vulnerability in urban areas: a pragmatic approach combining behavioral, medico-obstetrical, socio-economic and environmental factors

Pregnancy vulnerability in urban areas: a pragmatic approach combining behavioral, medico-obstetrical, socio-economic and environmental factors

Association between moderated level of air pollution and fetal growth: the potential role of noise exposure

Connecting Air Pollution Exposure to Socioeconomic Status: A Cross-Sectional Study on Environmental Injustice among Pregnant Women in Scania, Sweden

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