Multiple primary malignancies in Japanese patients with renal cell carcinoma

Abstract

Aim : To evaluate the incidence, nature and prognosis of multiple primary malignancies involving renal cell carcinoma (RCC) in Japan. Methods : Between 1975 and 1998, 319 patients underwent an operation for RCC at Hokkaido University, Sapporo, Japan. The incidence of other primary malignancies was determined and classified as antecedent, synchronous or subsequent. Follow-up was obtained by thorough chart review or telephone interview, and ranged from 0 to 276 months (median 49.0 months). To analyze the influence of other primary malignancies on prognosis, overall and cause-specific survival rates of the patients with an antecedent or synchronous malignancy were compared to the remaining patients.Results : Of the 319 patients there was at least one other malignancy in 38 patients (12%). Four patients had two other malignancies. The other malignancies were antecedent in 13, synchronous in 19 and subsequent in 10 patients. Twenty-two patients had gastrointestinal cancer. In cases of antecedent or synchronous diagnosis of other primary malignancies, RCC was commonly incidental, small or low-stage. Multivariate analysis using Cox's proportional hazards model showed that, for overall survival, the presence of other antecedent or synchronous malignancies was the second most significant prognostic factor, following the pathological stage of RCC. Conclusions : In Japanese patients with RCC, the incidence of other primary malignancies was not uncommon and these malignancies contributed to the prognosis of these patients. Therefore, the malignant potential of individual tumors should be paid careful attention in the management of these patients.

Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland

“…RCC is the most common tumor found to coexist with other malignancies [1,10,12,13,14]. In different studies the incidence of second primary malignancy associated with RCC is reported to be 12%-27.4% [1,10,11,14]. About 19% of these tumors appeared synchronously [1].…”

Synchronous carcinoma breast with renal cell carcinoma: A case report

“…All these associations can be metachronous (develop consequently) or synchronous (tumors coexist at the time of diagnosis). Synchronous breast and renal cell carcinoma (RCC) can occur rarely [3]. We hereby report a case of carcinoma breast with synchronous renal cell carcinoma.…”

“…Renal cancer is known to be associated with multiple tumors involving bladder, prostate, rectum, lung, non-Hodgkin's lymphoma, stomach and melanoma etc. [3]. Breast cancer is also associated with increased risk of second tumor involving colon, vulva, lung, larynx, liver, uterus and thyroid [4].…”

Multiple Primary Malignancies in Patients with Non-Small Cell Lung Cancer

“…Haraguchi et al conducted a single-institution retrospective analysis of multiple primary malignancies with NSCLC and reported gastric cancer to be the most prevalent neoplasm (33 of 938 patients) (17). In addition, Sato et al evaluated the incidence of multiple primary malignancies involving renal cell carcinoma (319 patients) and found that the most common other malignancy was gastric cancer (11 of 319 patients) (23). However, because gastric cancer is the most frequent malignancy in men and the third most common neoplasm in women in Japan, these results may simply reflect the epidemiological prevalence of this disease.…”