Multiple Primary Malignancies in Patients with Non-Small Cell Lung Cancer

Abstract

Objective Information regarding multiple primary malignancies is important, as it has the potential to clarify etiological factors and may indicate the need to refine patient follow-up to include screening for associated malignancies. Upper aerodigestive tract cancer often develops in patients with smoking-related lung cancer; however, little is known about the frequencies or types of other primary malignancies in patients with non-small cell lung cancer (NSCLC) without a history of smoking. Methods We retrospectively evaluated the records of patients examined and/or treated for NSCLC at the Institute of Biomedical Research and Innovation between January 2007 and June 2012. Patients In total, 938 patients, including 599 men (never-smoker/ever-smoker: 35/564) and 339 women (never-smoker/ever-smoker: 236/103), were analyzed. Results Among the 209 patients (22.3%) with multiple primary malignancies, 151 had a history of smoking and 58 were never-smokers. The most common cancers were gastric (43 cases), colorectal (33 cases), and prostate (29 cases) cancer. Smoking-related cancer was more common in current smokers and ex-smokers for both men and women. Among women with NSCLC, never-smokers were more likely to have thyroid cancer than those with a history of smoking (5.1% vs. 0%, p=0.021). Conclusion In this study, several differences in malignancies were observed between never-smokers and patients with a history of smoking. Thyroid cancer and NSCLC co-existed in some women without a history of smoking, implicating predisposing factors other than tobacco smoke in the onset of these cancers.

Phenotype-genotype correlation in multiple primary lung cancer patients in China

“…Previous studies3 have shown that MPLC is more common in 50- to 70-year-old male smokers; most tumors in these patients have been reported to be squamous carcinoma-squamous carcinoma, squamous carcinoma-adenocarcinoma or adenocarcinoma-adenocarcinoma. In contrast with these data, our findings suggests that MPLC is more common in females, although they confirm that 50- to 70-year-old patients represent the highest-risk age group.…”

“…MPLC was first reported in 19241. In recent years, the rate of diagnosis worldwide has rapidly increased due to the improvement in radiological diagnostic procedures such as high-resolution multi-slice spiral computed tomography (CT) and positron emission tomography (PET)2345. However, preoperative diagnosis can be problematic because it is often difficult to differentiate MPLC from lung cancer metastasis based on radiological and histopathological criteria alone.…”

Synchronous Duodenal Cancer and Lung Cancer Harboring an Epidermal Growth Factor Receptor Mutation Treated with Erlotinib and Oral Fluoropyrimidine

“…In lung cancer, 1.3% and 4.3% of patients are reported to have synchronous and metachronous cancers, respectively ( 2 ). Reportedly, the most common tumors that accompany lung cancer are gastrointestinal tumors ( 21 ). Although the current case was a rare case of lung cancer and duodenal cancer, the concurrent use of erlotinib and S-1 may be also applicable for multiple primary cancers with EGFR Mut lung carcinoma and other gastrointestinal tumors for which S-1 therapy is indicated.…”

Meta-Analysis and Systematic Review in Environmental Tobacco Smoke Risk of Female Lung Cancer by Research Type

“…We then read the full text of the remaining 117 studies. Studies that were impossible to distinguish female ETS exposure [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], studies without risk of ETS [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ], studies that were published more than once, studies with a subset of cases [ 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , …”