Multiple Primary Malignancies Involving Lung: An Analysis of 40 Cases

Yılmaz, Adnan; Ertuğrul, Müyesser; Tuncer, Leyla Yağcı; Sulu, Ebru; Damadoğlu, Ebru

doi:10.3109/2000-1967-229

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Therefore, this retrospective study was designed to evaluate the clinical characteristics and outcomes of MPM patients involving lung cancer in Chinese patients. The incidence of MPM patients involving lung cancer in our study was 3.4 % (185/5405), similar to the results of a previous study from Turkey, which found an incidence of 3.9 % (40/1038) [ 14 ]. The most frequent accompanying malignancies were colon, rectal, and esophageal cancers, which suggests that lung cancer may be closely associated with digestive system neoplasms.…”

Section: Discussionsupporting

confidence: 91%

Multiple primary malignancies involving lung cancer

Zhong

Niu

et al. 2015

BMC Cancer

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BackgroundThe incidence of multiple primary malignancies (MPM) has increased sharply in recent decades. However, the clinical characteristics and prognosis of MPM patients involving lung cancer were not fully elucidated. This retrospective study was designed to explore the clinical characteristics and prognosis of MPM patients involving lung cancer in the People’s Republic of China.MethodsOf 5405 lung cancer cases diagnosed at the Guangdong Lung Cancer Institute between 2005 and 2013, we analyzed 185 patients (3.4 %) with MPM involving lung cancer.ResultsAmong 185 patients with MPM involving lung cancer, 10 (5.4 %)had three malignancies and 175 (94.6 %) had two malignancies. 10 patients with three malignancies were excluded from the analysis to avoid misunderstanding. Of 175 accompanying malignancies, 64 (36.6 %) were synchronous MPM patients and 111 (63.4 %) were metachronous MPM patients; 49 (28.0 %) were lung cancer first MPM patients and 126 (72.0 %) were other cancer first MPM patients. The most frequent accompanying malignancy was colon cancer (25/175), followed by rectal cancer (18/175), esophageal cancer (17/175), and thyroid cancer (13/175). Metachronous MPM patients showed significantly better overall survival (OS) than synchronous MPM, with a median OS of 72.8 (range 12.2–391.0) and 12.9 (range 0.8–86.3)months, respectively (P < 0.001). Cox regression analysis revealed that time of occurrence and stage were independent factors for OS.ConclusionsColorectal cancer, esophageal cancer, and thyroid cancer were the tumors that most frequently accompanying lung cancer. Metachronous MPM patients showed significantly better OS compared with synchronous MPM patients.

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Section: Discussionsupporting

confidence: 91%

Multiple primary malignancies involving lung cancer

Zhong

Niu

et al. 2015

BMC Cancer

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“…that were accompanied by lung cancer have been investigated. [18][19][20] In a study conducted by Li et al, it was reported that the most common cancers to exist concurrently with lung cancer were of digestive system; breast cancer was included in the group of "others, " which compromised 9.7% of total. [21] However, another study reported that concurrence of lung and breast cancer made up highest percentage for both metachrone and synchrone groups of patients with multiple primary tumors.…”

Section: Case Reportmentioning

confidence: 99%

Medical Treatment with Two Targeted Therapies for an Oncology Patient with Double Primary Cancer: Case Report

Namal¹

2016

TJ Oncol

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SUMMARYWhile multiple primary tumors are rarely reported in literature, we expect that it will be seen more often in the future as a result of improvements in diagnosis and treatment of cancer. Molecular targeted therapies are promising modalities that are now used more commonly. Presently described is oncological response for a 70-year-old women with multiple primary cancers -breast and lung -in which 2 targeted therapies were administered. While there is currently no standard therapy in the literature for multiple primary cancers, it is the authors' suggestion that targeted therapies may be a promising choice for these cases.

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“…Furthermore, cancer treatment may also contribute to the development of MPMs, as conventional radiation therapy, chemotherapy, and antihormonal therapies are associated with an elevated risk of developing angiosarcoma, hematopoietic malignancies, and gynecological malignancies, respectively 1,11–13 . However, the majority of studies on MPMs to date have focused on specific cancer types 14–17 …”

Section: Introductionmentioning

confidence: 99%

“… 1 , 11 , 12 , 13 However, the majority of studies on MPMs to date have focused on specific cancer types. 14 , 15 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Genetic alterations associated with multiple primary malignancies

et al. 2021

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Breast cancer (BC) patients are frequently at risk of developing other malignancies following treatment. Although studies have been conducted to elucidate the etiology of multiple primary malignancies (MPM) after a BC diagnosis, few studies have investigated other previously diagnosed primary malignancies (OPPM) before BC. Here, genome‐wide profiling was used to identify potential driver DNA copy number alterations and somatic mutations that promote the development of MPMs. To compare the genomic profiles for two primary tumors (BC and OPPM) from the same patient, tumor pairs from 26 young women (≤50 years) diagnosed with one or more primary malignancies before breast cancer were analyzed. Malignant melanoma was the most frequent OPPM, followed by gynecologic‐ and hematologic malignancies. However, significantly more genetic alterations were detected in BC compared to the OPPM. BC also showed more genetic similarity as a group than the tumor pairs. Clonality testing showed that genetic alterations on chromosomes 1, 3, 16, and 19 were concordant in both tumors in 13 patients. TP53 mutations were also found to be prevalent in BC, MM, and HM. Although all samples were classified as genetically unstable, chromothripsis‐like patterns were primarily observed in BC. Taken together, few recurrent genetic alterations were identified in both tumor pairs that can explain the development of MPMs in the same patient. However, larger studies are warranted to further investigate key driver mutations associated with MPMs.

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Multiple Primary Malignancies Involving Lung: An Analysis of 40 Cases

Cited by 7 publications

References 17 publications

Multiple primary malignancies involving lung cancer

Multiple primary malignancies involving lung cancer

Medical Treatment with Two Targeted Therapies for an Oncology Patient with Double Primary Cancer: Case Report

Genetic alterations associated with multiple primary malignancies

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